Results 21 to 30 of about 50,429 (161)

Curcumin Attenuates Iron Accumulation and Oxidative Stress in the Liver and Spleen of Chronic Iron-Overloaded Rats. [PDF]

PLoS ONE, 2015
Iron overload is now recognized as a health problem in industrialized countries, as excessive iron is highly toxic for liver and spleen. The potential use of curcumin as an iron chelator has not been clearly identified experimentally in iron overload ...
Farid A Badria, Ahmed S Ibrahim, Adel F Badria, Ahmed A Elmarakby   +3 more
doaj   +1 more source

The evaluation of iron deficiency and iron overload

Deutsches Ärzteblatt international, 2021
In the western world, 10-15% of women of child-bearing age suffer from iron-deficiency anemia. Iron overload due to chronic treatment with blood transfusions or hereditary hemochromatosis is much rarer.This review is based on pertinent publications retrieved by a selective search on the pathophysiology, clinical features, and diagnostic evaluation of ...
Norbert, Gattermann, Martina U, Muckenthaler, Andreas E, Kulozik, Georgia, Metzgeroth, Jan, Hastka   +4 more
openaire   +2 more sources

Antioxidant effect of selenium and its Nano form on oxidative stress induced by iron overload [PDF]

Benha Veterinary Medical Journal, 2016
The aim of this study was to demonstrate the antioxidant effect of selenium in its ordinary and Nano form on oxidativestress induced by iron overload in male rat. This study was carried out on 90 rat, weighted 180-200 gm.
Samah Algharib, Abdalla A., Farid S., Fararh M.   +3 more
doaj   +1 more source

Iron Overload in Patients with Chronic Lymphocytic Leukemia Complicated by Autoimmune Hemolytic Anemia: A Case Report

Case Reports in Oncology, 2020
Iron overload is commonly seen in the context of hematological diseases in patients who require frequent transfusions. On the other hand, an association between autoimmune hemolytic anemia complicating chronic lymphocytic leukemia and iron overload is ...
Mohammad Ali, Mohamed A. Yassin
doaj   +1 more source

Iron Chelators in Treatment of Iron Overload

Journal of Toxicology, 2022
Patients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged. Although iron is a crucial element for life, iron overload can be potentially toxic for human cells due to its role in generating free radicals. In the past few decades, there has been a major
Sarina Entezari, Seyedeh Mona Haghi, Narges Norouzkhani, Barsa Sahebnazar, Fatemeh Vosoughian, Diba Akbarzadeh, Muhammad Islampanah, Navid Naghsh, Mohammad Abbasalizadeh, Niloofar Deravi   +9 more
openaire   +3 more sources

Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection

Brazilian Journal of Medical and Biological Research, 2006
The objective of the present study was to determine the presence of hepatic iron overload in patients with chronic HCV infection and to correlate it with histologic alterations, HCV genotype and response to therapy.
R.M. Souza, L.A.R. Freitas, A.C. Lyra, C.F. Moraes, E.L. Braga, L.G.C. Lyra   +5 more
doaj   +1 more source

A novel circPIK3C2A/miR‐31‐5p/TFRC axis drives ferroptosis and accelerates myocardial injury

MedComm
Iron overload is common in cardiovascular disease, it is also the factor that drives ferroptosis. Noncoding RNAs play an important role in heart disease; however, their regulatory role in iron overload‐mediated ferroptosis remains much unknown.
Shuo Miao, Lanting Yang, Tao Xu, Zhantao Liu, Yixiao Zhang, Lin Ding, Wei Ding, Xiang Ao, Jianxun Wang   +8 more
doaj   +1 more source

Parkin inhibits iron overload-induced cardiomyocyte ferroptosis by ubiquitinating ACSL4 and modulating PUFA-phospholipids metabolism

Acta Pharmaceutica Sinica B
Iron overload is strongly associated with heart disease. Ferroptosis is a new form of regulated cell death indicated in cardiac ischemia–reperfusion (I/R) injury.
Dandan Xiao, Wenguang Chang, Xiang Ao, Lin Ye, Weiwei Wu, Lin Song, Xiaosu Yuan, Luxin Feng, Peiyan Wang, Yu Wang, Yi Jia, Xiaopeng Tang, Jianxun Wang   +12 more
doaj   +1 more source

Iron Overload in Patients Undergoing Hematopoietic Stem Cell Transplantation

Advances in Hematology, 2010
Recipients of hematopoietic stem cell transplantation (HSCT) frequently have iron overload resulting from chronic transfusion therapy for anemia. In some cases, for example, in patients with myelodysplastic syndromes and thalassemia, this can be further ...
Vinod Pullarkat
doaj   +1 more source

Glucose and Lipid Profiles in Adolescents with Thalassemia Major and Its Association with Iron Overload in Specific Organs

Indonesian Biomedical Journal, 2019
BACKGROUND: Organ damage due to iron toxicity is one factor that increases the risk of getting cardiovascular and metabolic diseases in thalassemia patient. This study aims to determine glucose and lipid profiles in adolescents with thalassemia major and
Aryono Hendarto, Teny Tjitra Sari, Ludi Dhyani Rahmartani, Anggia Widyasari, Stephen Diah Iskandar   +4 more
doaj   +1 more source