Results 21 to 30 of about 122,333 (295)

Iron Overload Favors the Elimination of Leishmania [PDF]

, 2013
Iron plays a central role in host-parasite interactions, since both intervenients need iron for survival and growth, but are sensitive to iron-mediated toxicity. The host’s iron overload is often associated with susceptibility to infection. However, it
Appelberg, Rui, Gomes Pereira, Sandra Isabel, Gomes, Maria Salomé, Rodrigues, Pedro Nuno, Rosa, Gustavo, Teixeira, Carlos Miguel, Tomás, Ana, Vale-Costa, Sílvia   +7 more
core   +4 more sources

Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention. [PDF]

PLoS ONE, 2018
The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney ...
Avital Weiss, Lior Spektor, Lyora A Cohen, Lena Lifshitz, Inbar Magid Gold, De-Liang Zhang, Marianna Truman-Rosentsvit, Yael Leichtmann-Bardoogo, Abraham Nyska, Sefi Addadi, Tracey A Rouault, Esther G Meyron-Holtz   +11 more
doaj   +1 more source

Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models

Antioxidants, 2022
Hemoglobin and iron overload is considered the major contributor to intracerebral hemorrhage (ICH)-induced brain injury. Accumulation of iron in the brain leads to microglia activation, inflammation and cell loss.
Giuseppe Carota, Alfio Distefano, Mariarita Spampinato, Cesarina Giallongo, Giuseppe Broggi, Lucia Longhitano, Giuseppe A. Palumbo, Rosalba Parenti, Rosario Caltabiano, Sebastiano Giallongo, Michelino Di Rosa, Riccardo Polosa, Vincenzo Bramanti, Nunzio Vicario, Giovanni Li Volti, Daniele Tibullo   +15 more
doaj   +1 more source

Monoubiquitin-dependent endocytosis of the Iron-Regulated Transporter 1 (IRT1) transporter controls iron uptake in plants [PDF]

, 2011
Plants take up iron from the soil using the IRON-REGULATED TRANSPORTER 1 (IRT1) high-affinity iron transporter at the root surface. Sophisticated regulatory mechanisms allow plants to tightly control the levels of IRT1, ensuring optimal absorption of ...
Barberon, Marie, Zelazny, Eenric, Robert, Stephanie, Conejero, Geneviève, Curie, Cathy, Friml, Jiri, Vert, Grégory   +6 more
core   +3 more sources

Absence of cardiac siderosis by MRI T2* despite transfusion burden, hepatic and serum iron overload in Lebanese patients with sickle cell disease [PDF]

, 2009
Background:  The use of magnetic resonance imaging (MRI) to detect organ-specific iron overload is becoming increasingly common. Although hepatic iron overload has been recognized in patients with sickle cell disease (SCD), cardiac iron deposition has ...
Daou, Linda, Inati, Adlette, Musallam, Khaled, Sheikh-Taha, Marwan, Taher, Ali, Wood, John   +5 more
core   +1 more source

Impact of iron overload on interleukin-10 levels, biochemical parameters and oxidative stress in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia, 2013
OBJECTIVE: The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients.
Maritza Cavalcante Barbosa, Talyta Ellen Jesus dos Santos, Geane Félix de Souza, Lívia Coêlho de Assis, Max Victor Carioca Freitas, Romélia Pinheiro Gonçalves   +5 more
doaj   +3 more sources

Is iron overload associated with worse outcomes in patients with chronic liver disease undergoing liver transplantation?

Revista de Investigación Clínica
Background: Iron overload is frequent in patients with chronic liver disease, associated with shorter survival after liver transplantation in patients with hereditary hemochromatosis.
Sergio Rodriguez-Rodriguez, Antonio Olivas-Martínez, Jesus Delgado-de la Mora, Braulio Martinez-Benitez, Ignacio García-Juarez, Roberta Demichelis-Gómez   +5 more
doaj   +1 more source

Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice

Journal of Advanced Research
Introduction: Iron overload disrupts gut microbiota and induces ferroptosis, contributing to colitis. However, whether gut microbiota directly drives iron overload-induced colitis and its underlying mechanism remain unclear.
Ke Gu, Aimin Wu, Chen Liu, Bing Yu, Jun He, Xin Lai, Junzhou Chen, Yuheng Luo, Hui Yan, Ping Zheng, Junqiu Luo, Junning Pu, Quyuan Wang, Huifen Wang, Daiwen Chen   +14 more
doaj   +1 more source

Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine

Journal of Toxicology, 2018
Objective. The aim of our study is to compare the role of the new natural alternative (Quercetin) with the current iron-chelation therapy (Deferoxamine (DFO)) in the effect of iron overload on small intestinal tissues and to investigate the possible ...
Arwa A. El-Sheikh, Shimaa Hamed Ameen, Samaa Salah AbdEl-Fatah   +2 more
doaj   +1 more source

Interpreting iron studies [PDF]

, 2017
No abstract ...
Kelly, Alison U., McSorley, Stephen T., Patel, Prinesh, Talwar, Dinesh   +3 more
core   +1 more source