Results 11 to 20 of about 966,431 (294)

Iron overload and immunity [PDF]

World Journal of Gastroenterology, 2007
Progress in the characterization of genes involved in the control of iron homeostasis in humans and in mice has improved the definition of iron overload and of the cells affected by it. The cell involved in iron overload with the greatest effect on immunity is the macrophage.
Graça, Porto, Maria, De Sousa
openaire   +3 more sources

Identification of an iron–hepcidin complex [PDF]

, 2008
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was later shown to be a key player in iron homoeostasis. It is now proposed to be the 'iron hormone' which, by interacting with the iron transporter ferroportin,
Bui, T.T.T., Bui, Tam T.T., Rapisarda, C., Evans, R.W., Bui, T, Cammack, R, Drake, AF, Cammack, Richard, Rapisarda, C, Cammack, R., Drake, A, Evans, R W, Farnaud, SJ, Bui, TT, Evans, Robert W, Farnaud, Sebastien, Farnaud, S., Drake, Alex F., Evans, RW, Rapisarda, Chiara, Bui, Tam, Farnaud, Sébastien Jean-Claude, Drake, A.F., Farnaud, S   +23 more
core   +7 more sources

Estudi de les mutacions dels exons 2 i 4 del gen HFE en pacients amb porfiria cutània tarda esporàdica [PDF]

, 2006
[cat] La Porfíria Cutània Tarda (PCT) és una malaltia metabòlica que afecta a la pell i al fetge i que és desencadenada per la interacció de múltiples factors que inclouen l´herència, l´alcohol, el VHC, els estrògens i alguns agents tòxics, entre d ...
Toll Abelló, Agustí
core   +6 more sources

Genetic haemochromatosis: diagnosis and treatment of an iron overload disorder [PDF]

, 2022
Genetic haemochromatosis is a potentially serious iron overload disorder, yet there is a lack of awareness of the condition among the public and many healthcare professionals.
Mortimore, G., Johnson, M., Johnson, M, Mortimore, G   +3 more
core   +1 more source

How early can myocardial iron overload occur in Beta thalassemia major? [PDF]

, 2014
BACKGROUND: Myocardial siderosis is the most common cause of death in patients with beta thalassemia major(TM). This study aimed at investigating the occurrence, prevalence and severity of cardiac iron overload in a young Chinese population with beta TM.
Gaohui Yang, Pan Hongfei, He, T, Lai, Y, Peng, P, Liu Rongrong, Long, X, Taigang He, Tan Shaohong, Liu, R, Hongfei Pan, Yang Weijia, Xingjiang Long, Rongrong Liu, Lai Yongrong, Yang Gaohui, He Taigang, Weijia Yang, Yang, G, Xinhua Zhang, Tan, S, Liling Long, Anderson Lisa, Lisa Anderson, Long Xingjiang, Yang, W, Zhang, X, Anderson, L, Peng Peng, Yongrong Lai, Zhang Xinhua, Long Liling, Pan, H, Shaohong Tan, Long, L   +34 more
core   +2 more sources

Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]

, 2002
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem, Priem, F, Kaufmann, Stefan HE, Collins, Helen L, Ulrich E. Schaible, Kaufmann, S H E, Schaible, Ulrich E, Helen L. Collins, Collins, H L, Priem, Friedrich, Stefan H.E. Kaufmann, Schaible, U E   +11 more
core   +1 more source

Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload [PDF]

, 2010
Aim: We aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload.Methods and results: RV volumes, EF and mass were measured in 80 TM patients who had ...
Maciej Garbowski, He, TG, Maceira, A, Francisco Alpendurada, Banya Winston, He, T, Taigang He, Carpenter, JP, Smith, GC, Kirk, P, Shah, F, Maceira Alicia, Porter, JB, John B Porter, Banya, W, He Taigang, Walker, JM, Kirk Paul, Alicia Maceira, Alpendurada Francisco, Gillian C Smith, Porter John B, Smith Gillian C, Farrukh Shah, Pennell, DJ, Shah Farrukh, Pennell Dudley J, Deac Monica, Dudley J Pennell, Alpendurada, F, Paul Kirk, Winston Banya, Carpenter John-Paul, John-Paul Carpenter, Deac, M, J Malcolm Walker, Garbowski, M, Walker J Malcolm, Garbowski Maciej, Monica Deac   +39 more
core   +1 more source

Benefits and risks of iron supplementation in anemic neonatal pigs. [PDF]

, 2010
Iron deficiency is a common health problem. The most severe consequence of this disorder is iron deficiency anemia (IDA), which is considered the most common nutritional deficiency worldwide. Newborn piglets are an ideal model to explore the multifaceted
Olivier Thibaudeau, Paweł Kowalczyk, François Canonne-Hergaux, Thibaudeau, Olivier, Oliński, Ryszard, Zabielski, Romuald, Usińska, Agnieszka, Rafał R. Starzyński, Agnieszka Usińska, Woliński, Jarosław, Dziaman, Tomasz, Paweł Lipiński, Starzyński, Rafał R, Ewa Smuda, Jarosław Woliński, Barbara Tudek, Ryszard Oliński, Smuda, Ewa, Tomasz Dziaman, Romuald Zabielski, Kowalczyk, Paweł, Canonne-Hergaux, François, Tudek, Barbara, Gralak, Mikołaj A, Mikołaj A. Gralak, Lipiński, Paweł   +25 more
core   +2 more sources

Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan [PDF]

, 2014
There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complications of iron overload.
Alam, MH, Mohammed H Alam, He, T, Taigang He, Pennell, DJ, Gillian Smith, Carpenter, JP, Garbowski, MW, Dudley J Pennell, Maciej W Garbowski, John-Paul Carpenter, Porter, JB, John B Porter, Smith, G, Michael Roughton, Roughton, M   +15 more
core   +1 more source

Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment. [PDF]

, 2008
Background: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible ...
Tan, RS, Tan Ru, Chan, G.C.F, He, T, Fogel Mark A, Firmin David N, Au, W-Y, Pennell, Dudley J., Chan, GCF, Fogel, MA, Lam, W.M, Aydinok, Y, Chu, WCW, He, Taigang, Cohen, AR, Ng, I, Chu Winnie CW, Cohen, Alan R., Pennell, DJ, Pennell Dudley J, Firmin, D.N, Chu, W.C.W, Biceroglu, S, Fogel, M.A, Tan, R.S, Lam, WM, Chan Godfrey CF, Lam Wynnie M, Firmin, David N., Biceroglu Selen, Aydinok Yesim, Aydinok, Yesim, Firmin, DN, Kirk, Paul, Fogel, Mark A., Pennell, D.J, Ng Ivy, Kirk, P, Au, Wing-Yan, Tan, Ru San, Au, WY, He Taigang, Kirk Paul, Chan, GC, Biceroglu, Selen, Cohen, A.R, Au Wing-Yan, Chu, Winnie C. W., Chu, WC, Au, W.-Y, Lam, Wynnie M., Cohen Alan R, Ng, Ivy, Chan, Godfrey C. F.   +53 more
core   +1 more source