Results 41 to 50 of about 50,429 (161)

Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice

Scientific Reports
Iron overload has been associated with cerebrovascular disease and cognitive impairment in β-thalassaemia patients, typically appearing earlier than in the general population.
Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo   +7 more
doaj   +1 more source

Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice

Haematologica, 2018
There is increasing clinical evidence to suggest a suppressive effect on hematopoiesis in myelodysplastic syndrome patients with iron overload. However, how iron overload influences hematopoiesis in myelodysplastic syndrome (MDS) remains unknown.
Xin Jin, Xiaoyuan He, Xiaoli Cao, Ping Xu, Yi Xing, Songnan Sui, Luqiao Wang, Juanxia Meng, Wenyi Lu, Rui Cui, Hongyan Ni, Mingfeng Zhao   +11 more
doaj   +1 more source

Relationship between Hepatitis C Virus Infection and Iron Overload

Chinese Medical Journal, 2017
Objective: The aim of this study was to summarize the interactions between hepatitis C virus (HCV) infection and iron overload, and to understand the mechanisms of iron overload in chronic hepatitis C (CHC) and the role iron plays in HCV life cycle. Data
Dong-Mei Zou, Wan-Ling Sun
doaj   +1 more source

Oral iron overload.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1966
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Bothwell, Thomas H., Charlton, Robert W., Seftel, Harold C.   +2 more
openaire   +2 more sources

Evaluation of a new tablet formulation of deferasirox to reduce chronic iron overload after long-term blood transfusions

Therapeutics and Clinical Risk Management, 2016
Anna W Chalmers, Jamile M Shammo Department of Internal Medicine, Division of Hematology/Oncology, Rush University Medical Center, Chicago, IL, USA Abstract: Transfusion-dependent anemia is a common feature in a wide array of hematological disorders ...
Chalmers AW, Shammo JM
doaj  

Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis

Frontiers in Cardiovascular Medicine
Background/ObjectivesMyocardial and liver iron overload can be assessed through T2* in magnetic resonance imaging (MRI). It is unclear, how T2* measurements are associated with systolic and diastolic left ventricular function assessed by novel feature ...
Hugo G. Quezada-Pinedo, Benedikt Bernhard, Jan C. Zurkirchen, Anselm W. Stark, Noushin Sadat Ahanchi, Noushin Sadat Ahanchi, Catherine Gebhard, Daniel Ott, Alan A. Peters, Hendrik von Tengg-Kobligk, Jonathan Schütze, Adam Bakula, Andreas Wahl, Kim N. Cajachagua-Torres, Taulant Muka, Christoph Gräni   +15 more
doaj   +1 more source

Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis

Case Reports in Gastroenterology, 2015
Disturbances in iron metabolism can be genetic or acquired and accordingly manifest as primary or secondary iron overload state. Organ damage may result from iron overload and manifest clinically as cirrhosis, diabetes mellitus, arthritis, endocrine ...
Jasbir Makker, Ahmad Hanif, Bharat Bajantri, Sridhar Chilimuri   +3 more
doaj   +1 more source

Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia

Frontiers in Immunology
BackgroundThe hematopoietic ecosystem comprises both cellular components such as hematopoietic stem cells (HSCs) and immune cells as well as non-cellular components including iron.
Feifei Yang, Shulin Luo, Dan Yang, Xiaoxi Cui, Dongyue Zhang, Hao Wang, Yifei Li, Wanzhen Xie, Lina Wang, Lina Wang, Xiuqun Zhang, Guoguang Zheng, Guoguang Zheng, Xuezhong Zhang   +13 more
doaj   +1 more source

New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia

Haematologica, 2019
Genetic iron-overload disorders, mainly hereditary hemochromatosis and untransfused β-thalassemia, affect a large population worldwide. The primary etiology of iron overload in these diseases is insufficient production of hepcidin by the liver, leading ...
Jing Liu, Wei Liu, Yin Liu, Yang Miao, Yifan Guo, Haoyang Song, Fudi Wang, Hongyu Zhou, Tomas Ganz, Bing Yan, Sijin Liu   +10 more
doaj   +1 more source

Pathology of Hepatic Iron Overload

Seminars in Liver Disease, 2007
The growing availability of genetic tests for most inherited iron-overload conditions and our current ability to assess hepatic iron stores, and at a lesser extent, liver fibrosis by noninvasive methods have reduced the need for liver biopsy in patients with hepatic iron excess.
Yves, Deugnier, Bruno, Turlin
openaire   +3 more sources