Results 41 to 50 of about 966,431 (294)

Achieving High ON State Current through Ferroelectric Polarization‐Dependent Interfacial Resistance Switching in Undoped Orthorhombic HfO2 Films

Advanced Functional Materials, EarlyView.
Ferroelectric tunnel junction devices based on epitaxial undoped ferroelectric HfO2 films demonstrate stable switching endurance of over 106 switching cycles, low write voltages of ±3 V, 16 measured resistance states, and neuromorphic capability.
Markus Hellenbrand, Nuno Estrócio, Ji S. Kim, Babak Bakhit, Marian C. Istrate, Corneliu Ghica, Tiago Rebelo, Nives Strkalj, Abin Varghese, Bernardo Almeida, Luís S. Marques, Bipin Rajendran, Judith L. MacManus‐Driscoll, José P. B. Silva   +13 more
wiley   +1 more source

Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection

Brazilian Journal of Medical and Biological Research, 2006
The objective of the present study was to determine the presence of hepatic iron overload in patients with chronic HCV infection and to correlate it with histologic alterations, HCV genotype and response to therapy.
R.M. Souza, L.A.R. Freitas, A.C. Lyra, C.F. Moraes, E.L. Braga, L.G.C. Lyra   +5 more
doaj   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Iron Overload in Patients Undergoing Hematopoietic Stem Cell Transplantation

Advances in Hematology, 2010
Recipients of hematopoietic stem cell transplantation (HSCT) frequently have iron overload resulting from chronic transfusion therapy for anemia. In some cases, for example, in patients with myelodysplastic syndromes and thalassemia, this can be further ...
Vinod Pullarkat
doaj   +1 more source

Intelligent Maintenance Review for Robots: Multimodal Information, Deep Diagnosis and Embodied Artificial Intelligence

Advanced Robotics Research, EarlyView.
This review maps the methods to monitor robots’ health by fusing vibration, sound, control signals, vision, force, and oil information with artificial intelligence. It identifies deep learning, transfer learning, digital twins, and physics‐informed models as key methodological pathways enabling earlier diagnosis, safer human–robot collaboration, and ...
Yuting Qiao, Hongbo Wang, Naipeng Li, Shuo Wang, Yaguo Lei, Tonghai Wu, Junyi Cao   +6 more
wiley   +1 more source

A novel circPIK3C2A/miR‐31‐5p/TFRC axis drives ferroptosis and accelerates myocardial injury

MedComm
Iron overload is common in cardiovascular disease, it is also the factor that drives ferroptosis. Noncoding RNAs play an important role in heart disease; however, their regulatory role in iron overload‐mediated ferroptosis remains much unknown.
Shuo Miao, Lanting Yang, Tao Xu, Zhantao Liu, Yixiao Zhang, Lin Ding, Wei Ding, Xiang Ao, Jianxun Wang   +8 more
doaj   +1 more source

Parkin inhibits iron overload-induced cardiomyocyte ferroptosis by ubiquitinating ACSL4 and modulating PUFA-phospholipids metabolism

Acta Pharmaceutica Sinica B
Iron overload is strongly associated with heart disease. Ferroptosis is a new form of regulated cell death indicated in cardiac ischemia–reperfusion (I/R) injury.
Dandan Xiao, Wenguang Chang, Xiang Ao, Lin Ye, Weiwei Wu, Lin Song, Xiaosu Yuan, Luxin Feng, Peiyan Wang, Yu Wang, Yi Jia, Xiaopeng Tang, Jianxun Wang   +12 more
doaj   +1 more source

Brain iron content in systemic iron overload: a beta-thalassemia quantitative MRI study [PDF]

, 2019
Multisystem iron poisoning is a major concern for long-term beta-thalassemia management. Quantitative MRI-based techniques routinely show iron overload in heart, liver, endocrine glands and kidneys.
Concilio, Rosanna Di, Russo C., Femina G., Weiskopf, N. ; https://orcid.org/, Weiskopf N, Di Concilio R., Femina, Gianluca, Ciancio, Angela, Tartaglione I, Ponticorvo, Sara, Ciancio A, Esposito F., Manara, R., Tartaglione, I., Salle, Francesco Di, Ponticorvo S., Esposito, F., Manara, Renzo, Tartaglione, Immacolata, Russo C, Elefante A, Cirillo M., Cirillo M, Russo, C., Di Salle, F., Tartaglione I., Di Salle F, Carafa, Pasquale Alessandro, Manara R, De Michele E., De Michele, E., Femina G, Ciancio, A., De Michele, Elisa, Elefante A., Casale M, Carafa P. A., Casale, M., Ciancio A., Ponticorvo S, Weiskopf, Nikolaus, De Michele E, Perrotta S., Carafa, P., Perrotta S, Cirillo, Mario, Di Salle F., Di Concilio, R., Esposito F. Brain iron content in systemic iron overload: A beta-thalassemia quantitative MRI study, Esposito, Fabrizio, Perrotta, Silverio, Elefante, Andrea, Weiskopf N., Russo, Camilla, Perrotta, S., Di Concilio R, Ponticorvo, S., Femina, G., Manara R., Cirillo, M., Casale, Maddalena, Casale M., Elefante, A., Carafa PA   +63 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Glucose and Lipid Profiles in Adolescents with Thalassemia Major and Its Association with Iron Overload in Specific Organs

Indonesian Biomedical Journal, 2019
BACKGROUND: Organ damage due to iron toxicity is one factor that increases the risk of getting cardiovascular and metabolic diseases in thalassemia patient. This study aims to determine glucose and lipid profiles in adolescents with thalassemia major and
Aryono Hendarto, Teny Tjitra Sari, Ludi Dhyani Rahmartani, Anggia Widyasari, Stephen Diah Iskandar   +4 more
doaj   +1 more source