Results 51 to 60 of about 1,016,828 (293)

Curcumin Attenuates Iron Accumulation and Oxidative Stress in the Liver and Spleen of Chronic Iron-Overloaded Rats. [PDF]

PLoS ONE, 2015
Iron overload is now recognized as a health problem in industrialized countries, as excessive iron is highly toxic for liver and spleen. The potential use of curcumin as an iron chelator has not been clearly identified experimentally in iron overload ...
Farid A Badria, Ahmed S Ibrahim, Adel F Badria, Ahmed A Elmarakby   +3 more
doaj   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection

Brazilian Journal of Medical and Biological Research, 2006
The objective of the present study was to determine the presence of hepatic iron overload in patients with chronic HCV infection and to correlate it with histologic alterations, HCV genotype and response to therapy.
R.M. Souza, L.A.R. Freitas, A.C. Lyra, C.F. Moraes, E.L. Braga, L.G.C. Lyra   +5 more
doaj   +1 more source

A novel mutation in ferroportin implicated in iron overload

, 2007
Background/Aims: Hereditary iron overload is associated with mutations in a number of genes involved in the regulation of iron metabolism. In this study we examined the molecular basis of iron overload in an individual from New Zealand and characterised ...
Ramm, Grant A., Dixon, J.L., Powell, L.W., Wallace, Daniel F., Wallace, D.F., Subramaniam, V. Nathan, Ramm, G.A., Dixon, Jeannette L., Powell, Lawrie W., Anderson, G.J., Anderson, Gregory J., Subramaniam, V.N.   +11 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Benefits and risks of iron supplementation in anemic neonatal pigs. [PDF]

, 2010
Iron deficiency is a common health problem. The most severe consequence of this disorder is iron deficiency anemia (IDA), which is considered the most common nutritional deficiency worldwide. Newborn piglets are an ideal model to explore the multifaceted
Olivier Thibaudeau, Paweł Kowalczyk, François Canonne-Hergaux, Thibaudeau, Olivier, Oliński, Ryszard, Zabielski, Romuald, Usińska, Agnieszka, Rafał R. Starzyński, Agnieszka Usińska, Woliński, Jarosław, Dziaman, Tomasz, Paweł Lipiński, Starzyński, Rafał R, Ewa Smuda, Jarosław Woliński, Barbara Tudek, Ryszard Oliński, Smuda, Ewa, Tomasz Dziaman, Romuald Zabielski, Kowalczyk, Paweł, Canonne-Hergaux, François, Tudek, Barbara, Gralak, Mikołaj A, Mikołaj A. Gralak, Lipiński, Paweł   +25 more
core   +2 more sources

Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review

Health Science Reports
Background and Aims Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to study
Abdulqadir J. Nashwan, Mohammad T. Abuawwad, Jaber H. Jaradat, Anas Ibraheem, Mohamed A. Yassin, Mohammad J. J. Taha   +5 more
doaj   +1 more source

Iron overload and iron overload-related complications across the clinical spectrum of hemoglobin H disease: a real-world multicenter registry study from Thailand

Frontiers in Medicine
BackgroundIron overload presents as a major cause of long-term morbidity among thalassemia and is increasingly recognized in patients with hemoglobin (Hb) H disease; however, real-world clinical data defining the burden, complications, and associated ...
Sirichai Srichairatanakool, Sirichai Srichairatanakool, Chattree Hantaweepant, Duantida Songdej, Bunchoo Pongtanakul, Nattiya Teawtrakul, Pornpun Sripornsawan, Napat Laoaroon, Patcharee Komwilaisak, Arunotai Meekaewkunchorn, Pimlak Charoenkwan, Pimlak Charoenkwan, Pacharapan Surapolchai, Pranee Sutcharitchan, Noppacharn Uaprasert, Krissana Panrong, Sasinee Hantrakool, Sasinee Hantrakool, Supanun Lauhasurayotin, Kitti Torcharus, Panachai Silpsamrit, Adisak Tantiworawit, Adisak Tantiworawit   +22 more
doaj   +1 more source

Iron Chelators in Treatment of Iron Overload

Journal of Toxicology, 2022
Patients suffering from iron overload can experience serious complications. In such patients, various organs, such as endocrine glands and liver, can be damaged. Although iron is a crucial element for life, iron overload can be potentially toxic for human cells due to its role in generating free radicals. In the past few decades, there has been a major
Sarina Entezari, Seyedeh Mona Haghi, Narges Norouzkhani, Barsa Sahebnazar, Fatemeh Vosoughian, Diba Akbarzadeh, Muhammad Islampanah, Navid Naghsh, Mohammad Abbasalizadeh, Niloofar Deravi   +9 more
openaire   +3 more sources