Results 71 to 80 of about 1,016,828 (293)

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Quercetin Attenuates Iron Overload-Induced Renal Injury via Activating Nrf2/xCT/GPX4 Signaling to Inhibit Ferroptosis

Life
Iron overload, a key driver of ferroptosis, results from excessive iron accumulation in tissues and contributes to organ injury, including renal dysfunction.
Xiaoyi Wang, Wenmi Li, Wenzheng Yuan, Ziyu Wei, Zixuan Yang, Zichun Zhang, Zhibin Sun, Guojie Ji, Huanhuan Hu   +8 more
doaj   +1 more source

Iron Overload and Psychiatric Illness

, 1994
Seven patients with varying psychiatric disorders were found to have iron overload as manifested by abnormal serum ferritin, transferrin saturation index (TSI), or excessive urinary iron.
Paul Cutler
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Evaluating renal iron overload in diabetes mellitus by blood oxygen level-dependent magnetic resonance imaging: a longitudinal experimental study

BMC Medical Imaging, 2022
Background Iron overload plays a critical role in the pathogenesis of diabetic nephropathy. Non-invasive evaluation of renal iron overload in diabetes in the management and intervention of diabetic nephropathy is of great significance.
Weiwei Geng, Liang Pan, Liwen Shen, Yuanyuan Sha, Jun Sun, Shengnan Yu, Jianguo Qiu, Wei Xing   +7 more
doaj   +1 more source

IRON OVERLOAD STATES

Clinics in Liver Disease, 1998
Hereditary hemochromatosis is a common disorder of iron metabolism that increasingly is diagnosed and treated prior to the development of cirrhosis or diabetes. The discovery of a candidate gene for hereditary hemochromatosis undoubtedly will result in improved diagnosis of hereditary hemochromatosis and to a better understanding of certain aspects of ...
openaire   +2 more sources

Iron overload in Montpelier [PDF]

Gut, 2001
See article on page 836 Since the original discovery of the haemochromatosis gene (HFE) in 1996,1 there have been two genetic mutations that have dominated clinical studies. The C282Y mutation (845 G→A) has attracted the most attention as the majority of typical haemochromatosis patients are homozygotes for this mutation. This has increasingly led to
openaire   +2 more sources

Molecular pathogenesis of iron overload

, 2002
Our current understanding of iron absorption under normal conditions is presented, together with an overview of the clinical disorders of iron overload and the molecular processes that contribute to increased iron deposition in iron overload. Recently, a
Olynyk, J.K., D Trinder, Fox, C., G Vautier, Trinder, D., C Fox, Vautier, G., J K Olynyk   +7 more
core   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

MRI-detected hepatic and cardiac iron overload despite ferritin-guided chelation in thalassemia: A predictive modelling study

Pediatric Hematology Oncology Journal
Background: Serum ferritin while used widely, is often unable reflect organ-specific iron burden in thalassemia. We evaluated the adequacy of ferritin-guided chelation in predicting iron overload and examined determinants of ferritin–MRI discordance ...
Shruti Verma, Aprateem Mukherjee, Nita Radhakrishnan, Vineeta Ojha, Aditi Tulsiyan, Sudipto Bhattacharya, Anuj Singh, Usha Bindal, Tulika Seth, Priya Jagia   +9 more
doaj   +1 more source