Results 81 to 90 of about 122,333 (295)

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice

Scientific Reports
Iron overload has been associated with cerebrovascular disease and cognitive impairment in β-thalassaemia patients, typically appearing earlier than in the general population.
Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo   +7 more
doaj   +1 more source

Relationship between Hepatitis C Virus Infection and Iron Overload

Chinese Medical Journal, 2017
Objective: The aim of this study was to summarize the interactions between hepatitis C virus (HCV) infection and iron overload, and to understand the mechanisms of iron overload in chronic hepatitis C (CHC) and the role iron plays in HCV life cycle. Data
Dong-Mei Zou, Wan-Ling Sun
doaj   +1 more source

Calibration of myocardial T2 and T1 against iron concentration. [PDF]

, 2014
BACKGROUND: The assessment of myocardial iron using T2* cardiovascular magnetic resonance (CMR) has been validated and calibrated, and is in clinical use.
A John Baksi, Adam Fleming, AW Nienhuis, B Leonardi, B Modell, B Modell, CJ Yong-Hing, CM Wacker, D Verhaert, David N Firmin, DH Fitchett, DI Thickman, DR Messroghli, Dudley J Pennell, G Abbruzzese, GA Krombach, Gianluca Forni, Gildo Matta, Greg Black, Gualtiero Catani, H Miskin, J Malcolm Walker, JC Hsu, JC Wood, JC Wood, JH Jensen, JK Olynyk, John B Porter, John C Wood, John-Paul Carpenter, JP Carpenter, LA Saryan, Lisa J Anderson, LJ Anderson, LJ Anderson, LJ Olson, LJ Olson, M Barry, M Tovi, M Westwood, MA Tanner, MA Westwood, Mary N Sheppard, MD Cerqueira, Michael Roughton, Mike House, MW Garbowski, N Koizumi, NR Ghugre, P Kirk, Paul Kirk, PD Jensen, PT Telfer, RL Kamman, RL Kamman, SI Mavrogeni, SK Piechnik, Sofia V de Noronha, Suthat Fucharoen, T He, T He, T He, T He, Taigang He, TG St Pierre, Timothy G St. Pierre, W Chua-anusorn, W Collins, W Hosch, Y Feng   +69 more
core   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate). [PDF]

, 2019
Chronic kidney disease (CKD) is a major cause of morbidity and premature mortality and represents a significant global public health issue. Underlying this burden are the many complications of CKD, including mineral and bone disorders, anemia, and ...
Bino, Avi, Ganz, Tomas, Salusky, Isidro B   +2 more
core  

Evaluation of the Debye temperature for iron cores in human liver ferritin and its pharmaceutical analogue Ferrum Lek using Mossbauer spectroscopy [PDF]

, 2014
An iron polymaltose complex Ferrum Lek used as antianemic drug and considered as a ferritin analogue and human liver ferritin were investigated in the temperature range from 295K to 90K by means of 57Fe Mossbauer spectroscopy with a high velocity ...
Alenkina, I. V., Cieslak, J., Dubiel, S. M., Oshtrakh, M. I., Semionkin, V. A.   +4 more
core   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Evaluation of a new tablet formulation of deferasirox to reduce chronic iron overload after long-term blood transfusions

Therapeutics and Clinical Risk Management, 2016
Anna W Chalmers, Jamile M Shammo Department of Internal Medicine, Division of Hematology/Oncology, Rush University Medical Center, Chicago, IL, USA Abstract: Transfusion-dependent anemia is a common feature in a wide array of hematological disorders ...
Chalmers AW, Shammo JM
doaj  

Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis

Frontiers in Cardiovascular Medicine
Background/ObjectivesMyocardial and liver iron overload can be assessed through T2* in magnetic resonance imaging (MRI). It is unclear, how T2* measurements are associated with systolic and diastolic left ventricular function assessed by novel feature ...
Hugo G. Quezada-Pinedo, Benedikt Bernhard, Jan C. Zurkirchen, Anselm W. Stark, Noushin Sadat Ahanchi, Noushin Sadat Ahanchi, Catherine Gebhard, Daniel Ott, Alan A. Peters, Hendrik von Tengg-Kobligk, Jonathan Schütze, Adam Bakula, Andreas Wahl, Kim N. Cajachagua-Torres, Taulant Muka, Christoph Gräni   +15 more
doaj   +1 more source