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Iron chelating agents for iron overload diseases [PDF]
Thalassemia Reports, 2014 Although iron is an essential element for life, an excessive amount may become extremely toxic both for its ability to generate reactive oxygen species, and for the lack in humans of regulatory mechanisms for iron excretion.
Guido Crisponi +2 more
doaj +9 more sources
Potential of Application of Iron Chelating Agents in Ophthalmic Diseases [PDF]
Seminars in Ophthalmology, 2021 The investigations discussed in this review indicate that iron may exacerbate different eye diseases. Therefore, it is plausible that reducing cellular or body iron stores could influence disease pathogenesis, so it is logical to consider the iron chelators' potential protective role in the various ophthalmic diseases in the form of topical eye drops ...
Joseph B Ciolino
exaly +5 more sources
Structure of New Ferroverdins Recruiting Unconventional Ferrous Iron Chelating Agents [PDF]
Biomolecules, 2022 Ferroverdins are ferrous iron (Fe2+)-nitrosophenolato complexes produced by a few Streptomyces species as a response to iron overload. Previously, three ferroverdins were identified: ferroverdin A, in which three molecules of p-vinylphenyl-3-nitroso-4 ...
Loïc Martinet +3 more
doaj +2 more sources
A Speciation Study on the Perturbing Effects of Iron Chelators on the Homeostasis of Essential Metal Ions. [PDF]
PLoS ONE, 2015 A number of reports have appeared in literature calling attention to the depletion of essential metal ions during chelation therapy on β-thalassaemia patients.
Guido Crisponi +6 more
doaj +9 more sources
Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents [PDF]
MoleculesThe accumulation of iron in dopaminergic neurons can cause oxidative stress and dopaminergic neuron degeneration. Iron chelation therapy may reduce dopaminergic neurodegeneration, but chelators should be targeted towards dopaminergic cells. In this work,
Mahmoud El Safadi +6 more
doaj +2 more sources
Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and Lipid Peroxidation [PDF]
AntioxidantsFerroptosis and senescence are unique cellular processes that lead to irreversible cell abnormalities and tissue damage in many diseases, such as cancer, neurodegeneration, cardiac, liver, and kidney damage.
Malamati Kourti +1 more
doaj +2 more sources
Iron-chelating agents for treating malaria
The Cochrane Library, 2003 Researchers are exploring the effects of adding treatments to the main antimalarial regimens in an attempt to reduce mortality from Plasmodium falciparum. Iron chelation is one potential chemotherapeutic adjuvant treatment. Before advocating adjunctive therapy, the effects of iron chelators in improving patient outcomes need to be examined.To assess ...
Helen Smith, Martin M Meremikwu
exaly +6 more sources
A rapid assay for evaluation of iron-chelating agents in rats [PDF]
Blood, 1981 Abstract The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hepatocytes ...
Ca Finch
exaly +4 more sources
Therapeutic potential of iron chelators in retinal vascular diseases [PDF]
International Journal of Ophthalmology, 2023 Iron is one of the necessary metal elements in the human body. There are numerous factors that control the balance of iron metabolism, and its storage and transportation mechanisms are intricate.
Yan Li +3 more
doaj +1 more source
Role of Flavonoids in the Treatment of Iron Overload
Frontiers in Cell and Developmental Biology, 2021 Iron overload, a high risk factor for many diseases, is seen in almost all human chronic and common diseases. Iron chelating agents are often used for treatment but, at present, most of these have a narrow scope of application, obvious side effects, and ...
Xiaomin Wang +6 more
doaj +1 more source