Results 1 to 10 of about 1,905 (175)

The Era of Antimicrobial Peptides: Use of Hepcidins to Prevent or Treat Bacterial Infections and Iron Disorders

open access: yesFrontiers in Immunology, 2021
The current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens ...
Carolina Barroso   +11 more
doaj   +3 more sources

Insights into the Antimicrobial Properties of Hepcidins: Advantages and Drawbacks as Potential Therapeutic Agents

open access: yesMolecules, 2015
The increasing frequency of multi-drug resistant microorganisms has driven research into alternative therapeutic strategies. In this respect, natural antimicrobial peptides (AMPs) hold much promise as candidates for the development of novel antibiotics ...
Lisa Lombardi   +3 more
doaj   +3 more sources

Fish-derived hepcidins in cancer treatment: a scoping review

open access: yesBeni-Suef University Journal of Basic and Applied Sciences
Background The discovery of hepcidin, a peptide hormone primarily known for iron homeostasis regulation, has revealed promising anticancer properties.
Wan-Atirah Azemin   +4 more
doaj   +2 more sources

Human Antimicrobial Peptides as Therapeutics for Viral Infections

open access: yesViruses, 2019
Successful in vivo infection following pathogen entry requires the evasion and subversion of multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune pathways upregulated during infection by multiple pathogens, in ...
Aslaa Ahmed   +4 more
doaj   +3 more sources

Hepcidin as a risk marker for cardiovascular disease in periodontitis—A case control study

open access: yesJournal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Hepcidin is a 25 amino acid peptide expressed in the liver. Discovered as late as 2002, hepcidin is a master regulator of iron metabolism and is sensitive to inflammation. Chronic periodontitis, being an inflammatory condition, affects levels
Tejavathi Nagaraj   +5 more
doaj   +1 more source

Large Hepatocellular Adenoma Presenting with Iron Deficiency Anemia: A Case Report

open access: yesClinical Pediatric Hematology-Oncology, 2023
Hepatocellular adenoma is an uncommon, benign liver tumor usually occurring in patients using estrogen or anabolic androgens and in those with a genetic disease, including glycogen storage disease.
Young Kwon Koh   +7 more
doaj   +1 more source

Role of Hepcidins from Black Rockfish (Sebastes schlegelii) in Iron-Metabolic Function and Bacterial Defense

open access: yesJournal of Marine Science and Engineering, 2020
Hepcidin, an antimicrobial peptide produced by the liver, also controls the iron balance and regeneration in vertebrates. Two types of hepcidin (Hamp1 and Hamp2) have been found in the bodies of black rockfish (Sebastes schlegelii).
Yunqi Ma   +7 more
doaj   +1 more source

Verification of the Automated ELISA Assay for Hepcidin-25 in Human Serum

open access: yesSoutheastern European Medical Journal, 2023
Introduction: Hepcidin-25, the bioactive form of hepcidin, is the master protein in regulating iron homeostasis. Serum concentrations, measured by different methods, are often incomparable and complicate results interpretation.
Tara Rolić   +4 more
doaj   +1 more source

Immunometabolic involvement of hepcidin genes in iron homeostasis, storage, and regulation in gilthead seabream (Sparus aurata)

open access: yesFrontiers in Marine Science, 2022
Iron is essential for all living things, especially marine organisms, due to its low availability in the marine environment. Iron regulation is key in all vertebrates and is controlled by hepcidin–ferroportin. To improve the knowledge of iron homeostasis
Jhon A. Serna-Duque   +4 more
doaj   +1 more source

Immune Regulation, but Not Antibacterial Activity, Is a Crucial Function of Hepcidins in Resistance against Pathogenic Bacteria in Nile Tilapia (Oreochromis niloticus Linn.)

open access: yesBiomolecules, 2020
In this study, the functions of a recombinant propeptide (rProOn-Hep1) and the synthetic FITC-labelled mature peptides sMatOn-Hep1 and sMatOn-Hep2 were analyzed.
Pagaporn Phan-Aram   +4 more
doaj   +1 more source

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