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Effects of cholecalciferol and omega-3 fatty acids on hepcidin levels in 5/6 nephrectomy rats [PDF]
Kosin Medical JournalBackground Anemia is a common complication of chronic kidney disease (CKD). In patients with CKD-related anemia, an inverse relationship between vitamin D and hepcidin levels has been observed.
Yu In Jeong +6 more
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Hepcidin antagonists for potential treatments of disorders with hepcidin excess [PDF]
Frontiers in Pharmacology, 2014 The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide. Hepcidin binds ferroportin, the only cellular iron exporter, causing the internalization and degradation of both.
POLI, Maura +4 more
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Identification of Antibacterial Activity of Hepcidin From Antarctic Notothenioid Fish
Frontiers in Microbiology, 2022 Hepcidin is a small peptide composed of signal peptide, propeptide, and the bioactive mature peptide from N terminal to C terminal. Mature hepcidin is an antibacterial peptide and iron regulator with eight highly conserved cysteines forming four ...
Mingli Liu +11 more
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Human Antimicrobial Peptides and Proteins
Pharmaceuticals, 2014 As the key components of innate immunity, human host defense antimicrobial peptides and proteins (AMPs) play a critical role in warding off invading microbial pathogens.
Guangshun Wang
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JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013 Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red cells in macrophages and from storage in hepatocytes.
Subha Palaneeswari M. +4 more
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Can Dietary Iron Bioavailability Influence Colorectal Cancer Risk and Prognosis? [PDF]
Middle East Journal of CancerColorectal cancer (CRC) stands apart from other malignancies due to its pronounced association with dietary patterns. Approximately 70% of all CRC cases arise sporadically, and suboptimal dietary and lifestyle choices can override certain predisposing ...
Tara Rolić +3 more
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Brazilian Journal of Nephrology, 2020 Introduction: Glomerular hyperfiltration may lead to proteinuria and chronic kidney disease in unilateral multicystic dysplastic kidney (MCDK). We aimed to investigate the urine neutrophil-gelatinase-associated lipocalin (NGAL), netrin-1, hepcidin, and C-
Nuran Cetin +2 more
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The pathophysiology and pharmacology of hepcidin [PDF]
Trends in Pharmacological Sciences, 2014 Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias. Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical ...
Ruchala, Piotr, Nemeth, Elizabeta
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Antimicrobial Peptides as Mediators of Innate Immunity in Teleosts
Biology, 2015 Antimicrobial peptides (AMPs) have been identified throughout the metazoa suggesting their evolutionarily conserved nature and their presence in teleosts is no exception. AMPs are short (18–46 amino acids), usually cationic, amphipathic peptides.
Barbara A. Katzenback
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Hepcidin and sports anemia [PDF]
Cell & Bioscience, 2014 Iron is an important mineral element used by the body in a variety of metabolic and physiologic processes. These processes are highly active when the body is undergoing physical exercises. Prevalence of exercise-induced iron deficiency anemia (also known as sports anemia) is notably high in athletic populations, particularly those with heavy training ...
Kong, Wei-Na +2 more
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