Results 11 to 20 of about 1,905 (175)
The comparison of acute phase proteins in experimentally induced canine acute pancreatitis [PDF]
BMC Veterinary ResearchBackground Acute pancreatitis triggers the production of acute-phase proteins (APPs) in the body, among which C-reactive protein (CRP) is the most extensively studied and widely used for both diagnosis and prognosis. The diagnostic value of other APPs is
Eszter Tünde Kanyorszky +6 more
doaj +2 more sources
The Antimicrobial Peptide LJ-hep2 from Lateolabrax japonicus Exerting Activities against Multiple Pathogenic Bacteria and Immune Protection In Vivo [PDF]
Marine Drugs, 2022 Hepcidin is widely present in many kinds of fish and is an important innate immune factor. A variety of HAMP2-type hepcidins have strong antimicrobial activity and immunomodulatory functions and are expected to be developed as substitutes for antibiotics.
Ruihao Gong +4 more
doaj +2 more sources
Revolutionizing orthopedic healthcare: a systematic review unveiling recombinant antimicrobial peptides [PDF]
Frontiers in MicrobiologyThe increasing demand for orthopedic surgeries, including joint replacements, is driven by an aging population and improved diagnosis of joint conditions. Orthopedic surgeries carry a risk of infection, especially in patients with comorbidities. The rise
Vincenzo Pennone +6 more
doaj +2 more sources
Potential Usefulness of Urinary Hepcidin Measurement for Iron Deficiency Anemia in Female Athletes [PDF]
European Journal of Sport Science, Volume 26, Issue 6, June 2026.ABSTRACT Hepcidin is a key regulator of iron metabolism and has been proposed as a biomarker for detecting iron deficiency. This study examined serum hepcidin and non‐invasively measured urinary hepcidin in 260 female athletes to assess their potential utility in evaluating iron status. Urinary hepcidin/creatinine showed a strong correlation with serum
Haruo Hanawa +8 more
wiley +2 more sources
Clinical Journal of the American Society of Nephrology, 2009 Despite the use of erythropoiesis-stimulating agents (ESAs), the anemia of chronic kidney disease (CKD) can be resistant to therapy. Both absolute and functional iron deficiency along with inflammation can contribute to ESA resistance and can be difficult to identify with current-day markers of iron storage.
Brian, Young, Joshua, Zaritsky
openaire +2 more sources
Pharmaceuticals, 2018 Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to “hepcidinopathies” ranging from hereditary hemochromatosis to iron-refractory iron deficiency anemia, which are disorders caused by hepcidin deficiency or excess ...
Angeliki Katsarou, Kostas Pantopoulos
openaire +3 more sources
Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders [PDF]
The Scientific World JOURNAL, 2011 Iron is essential for human life, but toxic if present in excess. To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. At the systemic
CAMASCHELLA , CLARA, SILVESTRI L.
openaire +4 more sources
Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins
Biomedicines, 2021 The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution. Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which ...
Daniela Goncalves Monteiro +7 more
doaj +1 more source
Central Asian Journal of Medical Sciences, 2017 Objectives: The purpose of this study was to investigate the relationship between serum iron parameters with the activity of liver enzymes among patients with HCV in Mongolia.
Uugantsetseg Ganbold +2 more
doaj +1 more source
A tincture of hepcidin cures all: the potential for hepcidin therapeutics [PDF]
Journal of Clinical Investigation, 2010 Iron overload as a result of blood transfusions and excessive intestinal iron absorption can be a complication of chronic anemias such as β-thalassemia. Inappropriately low levels of hepcidin, a negative regulator of iron absorption and recycling, underlie the pathophysiology of the intestinal hyperabsorption. In this issue of the JCI, Gardenghi et al.
Thomas B, Bartnikas, Mark D, Fleming
openaire +2 more sources