Results 11 to 20 of about 1,887 (167)
Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins [PDF]
Biomedicines, 2021 The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution. Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which ...
Daniela Goncalves Monteiro +7 more
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[Rinsho ketsueki] The Japanese journal of clinical hematology, 2017 Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling macrophages, and from iron-storing hepatocytes. Hepcidin acts by binding to and inactivating the sole cellular iron exporter, ferroportin, which delivers iron to plasma from ...
A. M. Gressner, O. A. Gressner
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Pharmaceuticals, 2018 Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to “hepcidinopathies” ranging from hereditary hemochromatosis to iron-refractory iron deficiency anemia, which are disorders caused by hepcidin deficiency or excess ...
Angeliki Katsarou, Kostas Pantopoulos
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Large Hepatocellular Adenoma Presenting with Iron Deficiency Anemia: A Case Report
Clinical Pediatric Hematology-Oncology, 2023 Hepatocellular adenoma is an uncommon, benign liver tumor usually occurring in patients using estrogen or anabolic androgens and in those with a genetic disease, including glycogen storage disease.
Young Kwon Koh +7 more
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Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders [PDF]
The Scientific World JOURNAL, 2011 Iron is essential for human life, but toxic if present in excess. To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. At the systemic
CAMASCHELLA , CLARA, SILVESTRI L.
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Journal of Marine Science and Engineering, 2020 Hepcidin, an antimicrobial peptide produced by the liver, also controls the iron balance and regeneration in vertebrates. Two types of hepcidin (Hamp1 and Hamp2) have been found in the bodies of black rockfish (Sebastes schlegelii).
Yunqi Ma +7 more
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Verification of the Automated ELISA Assay for Hepcidin-25 in Human Serum
Southeastern European Medical Journal, 2023 Introduction: Hepcidin-25, the bioactive form of hepcidin, is the master protein in regulating iron homeostasis. Serum concentrations, measured by different methods, are often incomparable and complicate results interpretation.
Tara Rolić +4 more
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Frontiers in Marine Science, 2022 Iron is essential for all living things, especially marine organisms, due to its low availability in the marine environment. Iron regulation is key in all vertebrates and is controlled by hepcidin–ferroportin. To improve the knowledge of iron homeostasis
Jhon A. Serna-Duque +4 more
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Biomolecules, 2020 In this study, the functions of a recombinant propeptide (rProOn-Hep1) and the synthetic FITC-labelled mature peptides sMatOn-Hep1 and sMatOn-Hep2 were analyzed.
Pagaporn Phan-Aram +4 more
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Clinical Journal of the American Society of Nephrology, 2009 Despite the use of erythropoiesis-stimulating agents (ESAs), the anemia of chronic kidney disease (CKD) can be resistant to therapy. Both absolute and functional iron deficiency along with inflammation can contribute to ESA resistance and can be difficult to identify with current-day markers of iron storage.
Brian, Young, Joshua, Zaritsky
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