Results 1 to 10 of about 28,067 (241)

Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing. [PDF]

open access: yesPLoS ONE, 2017
Human α and β-defensins are cationic antimicrobial peptides characterized by three disulfide bonds with a triple stranded β-sheet motif. It is presumed that interaction with the bacterial cell surface and membrane permeabilization by defensins is an ...
Basil Mathew, Ramakrishnan Nagaraj
doaj   +2 more sources

In-Silico Tool for Predicting, Scanning, and Designing Defensins

open access: yesFrontiers in Immunology, 2021
Defensins are host defense peptides present in nearly all living species, which play a crucial role in innate immunity. These peptides provide protection to the host, either by killing microbes directly or indirectly by activating the immune system.
Chakit Arora   +2 more
exaly   +3 more sources

Medicinal Potentialities of Plant Defensins: A Review with Applied Perspectives

open access: yesMedicines, 2019
Plant-based secondary metabolites with medicinal potentialities such as defensins are small, cysteine-rich peptides that represent an imperative aspect of the inherent defense system.
Nida Ishaq   +2 more
doaj   +2 more sources

Defensins as a promising class of tick antimicrobial peptides: a scoping review

open access: yesInfectious Diseases of Poverty, 2022
Background Ticks are hematophagous parasites that transmit an extensive range of pathogens to their vertebrate hosts. Ticks can destroy invading microorganisms or alleviate infection via their rudimentary but orchestrated innate immune system ...
Jiahui Wu   +9 more
doaj   +1 more source

Alpha-defensins inhibit ERK/STAT3 signaling during monocyte-macrophage differentiation and impede macrophage function

open access: yesRespiratory Research, 2023
Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder associated with a 5–tenfold decrease in lung levels of alpha-1-antitrypsin (AAT) and an increased risk for obstructive lung disease.
Jungnam Lee   +5 more
doaj   +1 more source

A pilot study for evaluating the feasibility of using alpha-defensin to support the diagnosis of ventriculitis

open access: yesInternational Journal of Infectious Diseases, 2023
Objectives: Nosocomial ventriculitis is a difficult infectious condition to diagnose given that typical cerebral spinal fluid (CSF) parameters, commonly used in the diagnosis of meningitis, lack sensitivity and specificity in nosocomial ventriculitis ...
James B. Doub
doaj   +1 more source

Intestinal α-Defensins Play a Minor Role in Modulating the Small Intestinal Microbiota Composition as Compared to Diet

open access: yesMicrobiology Spectrum, 2023
The intestinal microbiota is at the interface between the host and its environment and thus under constant exposure to host-derived and external modulators.
Fabiola Puértolas-Balint   +1 more
doaj   +1 more source

FUNCTIONAL EFFECTS OF θ-DEFENSINS FROM BLOOD LEUKOCYTES OF BABOON PAPIO HAMADRYAS

open access: yesЖурнал микробиологии, эпидемиологии и иммунобиологии, 2018
Aim. Study the functional properties of cationic antimicrobial peptides 0-defensins isolated from baboon Papio hamadryas blood leukocytes. Materials and methods.
E. V. Tsvetkova   +5 more
doaj   +1 more source

A genome-wide screen identifies a single β-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins

open access: yesBMC Genomics, 2004
Background Defensins comprise a large family of cationic antimicrobial peptides that are characterized by the presence of a conserved cysteine-rich defensin motif.
Xiao Yanjing   +6 more
doaj   +1 more source

α-Defensins Promote Bacteroides Colonization on Mucosal Reservoir to Prevent Antibiotic-Induced Dysbiosis

open access: yesFrontiers in Immunology, 2020
In addition to their established functions in host defense, accumulating evidence has suggested an emerging role for antimicrobial proteins (AMPs) in shaping commensal microbiota.
Jiayao Ou   +11 more
doaj   +1 more source

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