Results 1 to 10 of about 1,130 (180)
In-Silico Tool for Predicting, Scanning, and Designing Defensins
Frontiers in Immunology, 2021 Defensins are host defense peptides present in nearly all living species, which play a crucial role in innate immunity. These peptides provide protection to the host, either by killing microbes directly or indirectly by activating the immune system.
Dilraj Kaur +2 more
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Defensins in periodontal health
Indian Journal of Dental Research, 2015 Defensins are abundant and widely distributed peptides in human and animal tissues that are involved in host defence. Defensins not only have the ability to strengthen the innate immune system but can also enhance the adaptive immune system by chemotaxis
Taran Bedi +2 more
doaj +3 more sources
Role of Defensins in Tumor Biology
International Journal of Molecular Sciences, 2023 Defensins have long been considered as merely antimicrobial peptides. Throughout the years, more immune-related functions have been discovered for both the α-defensin and β-defensin subfamily. This review provides insights into the role of defensins in tumor immunity.
Lowie Adyns +2 more
exaly +5 more sources
Clinical Immunology Newsletter, 1987 Abstract: Defensins are a family of small, variably cationic proteins which are highly abundant in the granules of mammalian phagocytes. Three defensins, HNP‐1, 2, and 3, comprise 30–50% of total protein in azurophil granules of human neutrophils. Some defensins are broadly antimicrobial, antiviral and cytotoxic, while others are chemotactic, opsonic,
T, Ganz, M E, Selsted, R I, Lehrer
openaire +2 more sources
Defensins as a promising class of tick antimicrobial peptides: a scoping review
Infectious Diseases of Poverty, 2022 Background Ticks are hematophagous parasites that transmit an extensive range of pathogens to their vertebrate hosts. Ticks can destroy invading microorganisms or alleviate infection via their rudimentary but orchestrated innate immune system ...
Jiahui Wu +9 more
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BioMed Research International, 2014 Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues.
Xie, Guo-Hao +3 more
openaire +2 more sources
Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing. [PDF]
PLoS ONE, 2017 Human α and β-defensins are cationic antimicrobial peptides characterized by three disulfide bonds with a triple stranded β-sheet motif. It is presumed that interaction with the bacterial cell surface and membrane permeabilization by defensins is an ...
Basil Mathew, Ramakrishnan Nagaraj
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Respiratory Research, 2023 Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder associated with a 5–tenfold decrease in lung levels of alpha-1-antitrypsin (AAT) and an increased risk for obstructive lung disease.
Jungnam Lee +5 more
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International Journal of Infectious Diseases, 2023 Objectives: Nosocomial ventriculitis is a difficult infectious condition to diagnose given that typical cerebral spinal fluid (CSF) parameters, commonly used in the diagnosis of meningitis, lack sensitivity and specificity in nosocomial ventriculitis ...
James B. Doub
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Microbiology Spectrum, 2023 The intestinal microbiota is at the interface between the host and its environment and thus under constant exposure to host-derived and external modulators.
Fabiola Puértolas-Balint +1 more
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