Exploring the therapeutic potential of recombinant bovine β-defensins for antimicrobial and anti-inflammatory functions in sepsis management [PDF]
Veterinary Researchβ-defensins are multifunctional peptides of the host immune system involved in responses to infectious diseases. We investigated the potential of five recombinant proteins based on bovine β-defensins (bovine neutrophil β-defensins (BNBD) 1, 2, 3, and 4 ...
Cristina Saubi +7 more
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Mechanisms and regulation of defensins in host defense
Signal Transduction and Targeted Therapy, 2023 As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to host defense.
Mingliang Jin, Junxia Min, Fudi Wang
exaly +2 more sources
Defensins in periodontal health
Indian Journal of Dental Research, 2015 Defensins are abundant and widely distributed peptides in human and animal tissues that are involved in host defence. Defensins not only have the ability to strengthen the innate immune system but can also enhance the adaptive immune system by chemotaxis
Taran Bedi +2 more
doaj +3 more sources
Snake venom defensins: Defining the structural and functional characteristics of the toxin family [PDF]
Journal of Structural Biology: XSnake venom defensins are a toxin family found in rattlesnake venoms (Crotalus) which are comprised of crotamine-like peptides and myotoxins. Their tertiary structure resembles the β-defensin family structure.
David Melendez-Martinez +7 more
doaj +2 more sources
Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease. [PDF]
, 2013 Dry eye disease can cause ocular surface inflammation that disrupts the corneal epithelial barrier. While dry eye patients are known to have an increased risk of corneal infection, it is not known whether there is a direct causal relationship between ...
Evans, David +4 more
core +16 more sources
In-Silico Tool for Predicting, Scanning, and Designing Defensins
Frontiers in Immunology, 2021 Defensins are host defense peptides present in nearly all living species, which play a crucial role in innate immunity. These peptides provide protection to the host, either by killing microbes directly or indirectly by activating the immune system.
Dilraj Kaur +5 more
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Clinical Immunology Newsletter, 1987 Abstract: Defensins are a family of small, variably cationic proteins which are highly abundant in the granules of mammalian phagocytes. Three defensins, HNP‐1, 2, and 3, comprise 30–50% of total protein in azurophil granules of human neutrophils. Some defensins are broadly antimicrobial, antiviral and cytotoxic, while others are chemotactic, opsonic,
T, Ganz, M E, Selsted, R I, Lehrer
openaire +2 more sources
Defensins as a promising class of tick antimicrobial peptides: a scoping review
Infectious Diseases of Poverty, 2022 Background Ticks are hematophagous parasites that transmit an extensive range of pathogens to their vertebrate hosts. Ticks can destroy invading microorganisms or alleviate infection via their rudimentary but orchestrated innate immune system ...
Jiahui Wu +9 more
doaj +1 more source
Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing. [PDF]
PLoS ONE, 2017 Human α and β-defensins are cationic antimicrobial peptides characterized by three disulfide bonds with a triple stranded β-sheet motif. It is presumed that interaction with the bacterial cell surface and membrane permeabilization by defensins is an ...
Basil Mathew, Ramakrishnan Nagaraj
doaj +1 more source
An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]
, 2020 beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip +8 more
core +2 more sources