Results 11 to 20 of about 22,371 (222)

Defensins in periodontal health

Indian Journal of Dental Research, 2015
Defensins are abundant and widely distributed peptides in human and animal tissues that are involved in host defence. Defensins not only have the ability to strengthen the innate immune system but can also enhance the adaptive immune system by chemotaxis
Taran Bedi, Jaideep Mahendra, N Ambalavanan   +2 more
doaj   +3 more sources

Defensins [PDF]

Clinical Immunology Newsletter, 1987
Abstract: Defensins are a family of small, variably cationic proteins which are highly abundant in the granules of mammalian phagocytes. Three defensins, HNP‐1, 2, and 3, comprise 30–50% of total protein in azurophil granules of human neutrophils. Some defensins are broadly antimicrobial, antiviral and cytotoxic, while others are chemotactic, opsonic,
T, Ganz, M E, Selsted, R I, Lehrer
openaire   +2 more sources

Defensins and Sepsis [PDF]

BioMed Research International, 2014
Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues.
Xie, Guo-Hao, Chen, Qi-Xing, Cheng, Bao-Li, Fang, Xiang-Ming   +3 more
openaire   +2 more sources

Avian defensins

Veterinary Immunology and Immunopathology, 2008
Modulation of defensin expression may be one way to improve animal health and to reduce zoonotic diseases. Defensins are small, cationic, and amphipathic cysteine-rich antibiotic peptides found in plants, insects, mammals and birds. Whereas alpha- and theta-defensins appear to be absent in birds, several beta-defensins have been isolated from avian ...
van Dijk, A., Veldhuizen, E.J.A., Haagsman, H.P.   +2 more
openaire   +4 more sources

A genome-wide screen identifies a single β-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins

BMC Genomics, 2004
Background Defensins comprise a large family of cationic antimicrobial peptides that are characterized by the presence of a conserved cysteine-rich defensin motif.
Xiao Yanjing, Hughes Austin L, Ando Junko, Matsuda Yoichi, Cheng Jan-Fang, Skinner-Noble Donald, Zhang Guolong   +6 more
doaj   +1 more source

Medicinal Potentialities of Plant Defensins: A Review with Applied Perspectives

Medicines, 2019
Plant-based secondary metabolites with medicinal potentialities such as defensins are small, cysteine-rich peptides that represent an imperative aspect of the inherent defense system.
Nida Ishaq, Muhammad Bilal, Hafiz M.N. Iqbal   +2 more
doaj   +1 more source

α-Defensins Promote Bacteroides Colonization on Mucosal Reservoir to Prevent Antibiotic-Induced Dysbiosis

Frontiers in Immunology, 2020
In addition to their established functions in host defense, accumulating evidence has suggested an emerging role for antimicrobial proteins (AMPs) in shaping commensal microbiota.
Jiayao Ou, Jiayao Ou, Jiayao Ou, Shaonan Liang, Shaonan Liang, Shaonan Liang, Xue-Kun Guo, Xue-Kun Guo, Xue-Kun Guo, Xiaoyu Hu, Xiaoyu Hu, Xiaoyu Hu   +11 more
doaj   +1 more source

Elevated Concentration of Defensins in Hepatitis C Virus-Infected Patients

Journal of Immunology Research, 2016
Hepatitis C virus (HCV) is the major etiological agent of human non-A and non-B hepatitis, affecting around 180 million people worldwide. Defensins, small cysteine-rich cationic peptides, are shown to have potent antibacterial, antiviral, and antifungal ...
Ehab H. Mattar, Hussein A. Almehdar, Abdullah A. AlJaddawi, Isam ElDin M. Abu Zeid, Elrashdy M. Redwan   +4 more
doaj   +1 more source

Antiplasmodial activity is an ancient and conserved feature of tick defensins

Frontiers in Microbiology, 2016
Ancestral sequence reconstruction has been widely used to test evolution-based hypotheses. The genome of the European tick vector, Ixodes ricinus, encodes for defensin peptides with diverse antimicrobial activities against distantly related pathogens ...
Alejandro Cabezas-Cruz, Miray Tonk, Anne Bouchut, Christine Pierrot, Raymond John Pierce, Michail Kotsyfakis, Mohammad Rahnamaeian, Andreas Vilcinskas, Jamal Khalife, James Jason Valdes   +9 more
doaj   +1 more source

Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics

Molecules, 2017
Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and high serum stability, which is useful to develop and design novel antimicrobial agents.
Annarita Falanga, Ersilia Nigro, Margherita Gabriella De Biasi, Aurora Daniele, Giancarlo Morelli, Stefania Galdiero, Olga Scudiero   +6 more
doaj   +1 more source