Inflammatory burden in dialysis patients: the role of alpha defensin [PDF]
Frontiers in ImmunologyIntroductionThe major neutrophilic peptide alpha-defensin plays a pivotal role in atherogenesis. Atherosclerosis is more frequent in dialysis patients, increasingly ascribed to chronic low-grade inflammation.
Maanit Shapira +5 more
doaj +2 more sources
Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome [PDF]
BMC Genomics, 2009 Background Host defense peptides are a critical component of the innate immune system. Human alpha- and beta-defensin genes are subject to copy number variation (CNV) and historically the organization of mouse alpha-defensin genes has been poorly defined.
Dougan Gordon +6 more
doaj +3 more sources
NOD2/RICK-dependent β-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection. [PDF]
, 2014 Middle ear infection, otitis media (OM), is clinically important due to the high incidence in children and its impact on the development of language and motor coordination.
Lee, Yoo Jin +5 more
core +17 more sources
A Novel Approach on Leukodepletion Filters: Investigation of Synergistic Anticancer Effect of Purified α-Defensins and Nisin [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: There are number of reports available regarding defensins activity against mammalian cells besides their antimicrobial and immune regulatory activities.
Niloofar Sasani +3 more
doaj +1 more source
Roles of Different β-Defensins in the Human Reproductive System: A Review Study
American Journal of Men's Health, 2023 Human β-defensins (hBDs) are cationic peptides with an amphipathic spatial shape and a high cysteine content. The members of this peptide family have been found in the human body with various functions, including the human reproductive system. Of among β-
Farzaneh Fesahat +3 more
doaj +1 more source
Cloning and Expression of β-Defensin from Soiny Mullet (Liza haematocheila), with Insights of its Antibacterial Mechanism. [PDF]
PLoS ONE, 2016 Beta-defensins are important part of innate immunity of fish, which are the first defense line against invading pathogens. In this study, the β-defensin (Lhβ-defensin) gene was cloned from spleen tissue of soiny mullet (Liza haematocheila).
Zhitao Qi +5 more
doaj +1 more source
Dysregulation of human beta-defensin-3 expression in the peripheral blood of patients with sepsis
SAGE Open Medicine, 2021 Objectives: Sepsis is a serious medical condition caused by the body’s systemic inflammatory response to infections. The antimicrobial peptides, human beta-defensins, play a key role in modulating host immune responses, and aberrant expression of human ...
Noura Al Mansour +3 more
doaj +1 more source
Scientific Reports, 2023 Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by fibrosis that develops from fatty liver. Disruption of intestinal microbiota homeostasis, dysbiosis, is associated with fibrosis development in NASH. An antimicrobial peptide
Shunta Nakamura +12 more
doaj +1 more source
Parasites & Vectors, 2023 Background The body and head lice of humans are conspecific, but only the body louse functions as a vector to transmit bacterial pathogens such as Bartonella quintana. Both louse subspecies have only two antimicrobial peptides, defensin 1 and defensin 2.
Kyungjae Andrew Yoon +3 more
doaj +1 more source
An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]
, 2020 beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip +8 more
core +2 more sources