Results 1 to 10 of about 42,582 (271)
eLife, 2019 Antimicrobial peptides (AMPs) are small cationic molecules best known as mediators of the innate defence against microbial infection. While in vitro and ex vivo evidence suggest AMPs’ capacity to kill cancer cells, in vivo demonstration of an anti-tumour
Jean-Philippe Parvy +8 more
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Inflammatory burden in dialysis patients: the role of alpha defensin [PDF]
Frontiers in ImmunologyIntroductionThe major neutrophilic peptide alpha-defensin plays a pivotal role in atherogenesis. Atherosclerosis is more frequent in dialysis patients, increasingly ascribed to chronic low-grade inflammation.
Maanit Shapira +5 more
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Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions [PDF]
Journal of Virology, 2016 ABSTRACT Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro . The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus ...
Sarah S. Wilson +3 more
semanticscholar +3 more sources
A Novel Approach on Leukodepletion Filters: Investigation of Synergistic Anticancer Effect of Purified α-Defensins and Nisin [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: There are number of reports available regarding defensins activity against mammalian cells besides their antimicrobial and immune regulatory activities.
Niloofar Sasani +3 more
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Clinical Immunology Newsletter, 1987 Abstract: Defensins are a family of small, variably cationic proteins which are highly abundant in the granules of mammalian phagocytes. Three defensins, HNP‐1, 2, and 3, comprise 30–50% of total protein in azurophil granules of human neutrophils. Some defensins are broadly antimicrobial, antiviral and cytotoxic, while others are chemotactic, opsonic,
T, Ganz, M E, Selsted, R I, Lehrer
openaire +2 more sources
Roles of Different β-Defensins in the Human Reproductive System: A Review Study
American Journal of Men's Health, 2023 Human β-defensins (hBDs) are cationic peptides with an amphipathic spatial shape and a high cysteine content. The members of this peptide family have been found in the human body with various functions, including the human reproductive system. Of among β-
Farzaneh Fesahat +3 more
doaj +1 more source
Cloning and Expression of β-Defensin from Soiny Mullet (Liza haematocheila), with Insights of its Antibacterial Mechanism. [PDF]
PLoS ONE, 2016 Beta-defensins are important part of innate immunity of fish, which are the first defense line against invading pathogens. In this study, the β-defensin (Lhβ-defensin) gene was cloned from spleen tissue of soiny mullet (Liza haematocheila).
Zhitao Qi +5 more
doaj +1 more source
A biomimetic peptide recognizes and traps bacteria in vivo as human defensin-6
Science Advances, 2020 A biomimetic peptide recognizes and traps bacteria in vivo as human defensin-6 for inhibiting the invasion of host cells. Using broad-spectrum antibiotics for microbial infection may cause flora disequilibrium, drug-resistance, etc., seriously ...
Yu Fan +12 more
semanticscholar +1 more source
Dysregulation of human beta-defensin-3 expression in the peripheral blood of patients with sepsis
SAGE Open Medicine, 2021 Objectives: Sepsis is a serious medical condition caused by the body’s systemic inflammatory response to infections. The antimicrobial peptides, human beta-defensins, play a key role in modulating host immune responses, and aberrant expression of human ...
Noura Al Mansour +3 more
doaj +1 more source
BioMed Research International, 2014 Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues.
Xie, Guo-Hao +3 more
openaire +2 more sources