Results 21 to 30 of about 37,059 (248)

Age-Related Expression of IFN-λ1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals

Frontiers in Immunology, 2021
SARS-CoV-2 coronavirus infection induces heterogeneous symptoms, ranging from asymptomatic to lethal forms. Severe forms usually occur in the elderly and/or individuals with comorbidities.
Charly Gilbert, Charly Gilbert, Caroline Lefeuvre, Caroline Lefeuvre, Laurence Preisser, Adeline Pivert, Adeline Pivert, Raffaella Soleti, Simon Blanchard, Simon Blanchard, Yves Delneste, Yves Delneste, Alexandra Ducancelle, Alexandra Ducancelle, Dominique Couez, Pascale Jeannin, Pascale Jeannin   +16 more
doaj   +1 more source

Avian defensins

Veterinary Immunology and Immunopathology, 2008
Modulation of defensin expression may be one way to improve animal health and to reduce zoonotic diseases. Defensins are small, cationic, and amphipathic cysteine-rich antibiotic peptides found in plants, insects, mammals and birds. Whereas alpha- and theta-defensins appear to be absent in birds, several beta-defensins have been isolated from avian ...
van Dijk, A., Veldhuizen, E.J.A., Haagsman, H.P.   +2 more
openaire   +4 more sources

Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture

Viruses, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more than two million deaths worldwide since it was first detected in 2019.
Allison Bakovic, Kenneth Risner, Nishank Bhalla, Farhang Alem, Theresa L. Chang, Warren K. Weston, Jane A. Harness, Aarthi Narayanan   +7 more
doaj   +1 more source

Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.

, 2009
Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy ...
M. Kamsteeg (7607603), G. S. Tjabringa (7607606), G. J. de Jongh (7607609), P. L. Zeeuwen (7583042), E. M. de Jong (7607621), M. M. van Rossum (7607618), Edward J. Hollox (7583051), J. G. Bergboer (7607615), A. W. Evers (7607624), I. M. van Vlijmen-Willems (7607612), D. Rodijk-Olthuis (7607600), M. Bergers (7607627), J. A. Armour (7607630), P. A. Jansen (7607597), J. Schalkwijk (7583048), M. den Heijer (7583045)   +15 more
core   +3 more sources

Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides

Frontiers in Immunology, 2021
Defects in the mucosal barrier have been associated with metabolic diseases such as obesity and non-alcoholic fatty liver disease (NAFLD). Mice fed a Western-style diet (WSD) develop obesity and are characterized by a diet-induced intestinal barrier ...
Julia Beisner, Louisa Filipe Rosa, Valentina Kaden-Volynets, Iris Stolzer, Claudia Günther, Stephan C. Bischoff   +5 more
doaj   +1 more source

β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development

Scientific Reports, 2017
β-defensin family plays a role in host defense against viral infection, however its role in HCV infection is still unknown. In this study, we demonstrated that β-defensin 1 was significantly reduced in HCV-infected liver specimens.
Yue-Ming Ling, Jin-Yu Chen, Libin Guo, Chen-Yi Wang, Wen-Ting Tan, Qing Wen, Shu-Dong Zhang, Guo-Hong Deng, Yao Lin, Hang Fai Kwok   +9 more
doaj   +1 more source

β-Defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin

, 2009
Background Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin ...
M. Kamsteeg (7607603), G. S. Tjabringa (7607606), de Jong E. M. G. J. (7620323), A. W. M. Evers (7620332), P. A. M. Jansen (7620308), den Heijer M. (7620329), Edward J. Hollox (7583051), J. G. M. Bergboer (7620317), D. Rodijk-Olthuis (7607600), van Rossum M. M. (7620320), de Jongh G. J. (7620311), M. Bergers (7607627), P. L. J. M. Zeeuwen (7620326), van Vlijmen-Willems I. M. J. J. (7620314), J. Schalkwijk (7583048), J. A. L. Armour (7618973)   +15 more
core   +3 more sources

Gene Expression in Cucurbita spp. Root and Crown during Phytophthora capsici Infection

Plants, 2021
Phytophtora capsici causes major diseases in cucurbit crops worldwide. In this study, we inoculated this pathogen into Cucurbita pepo subsp. pepo susceptible MUCU-16 and C. moschata tolerant M63. The gene expression of plant pathogenesis-related proteins
Alejandro Ayala-Doñas, Pedro Gómez, Miguel de Cara-García   +2 more
doaj   +1 more source

Artificial β-defensin based on a minimal defensin template

Biochemical Journal, 2009
We have designed and chemically synthesized an artificial β-defensin based on a minimal template derived from the comparative analysis of over 80 naturally occurring sequences. This molecule has the disulfide-bridged β-sheet core structure of natural β-defensins and shows a robust salt-sensitive antimicrobial activity against bacteria and yeast, as ...
ANTCHEVA, Nikolinka, MORGERA F, CREATTI L, VACCARI, LISA, PAG U, PACOR, SABRINA, SHAI Y, SAHL H. G, TOSSI, ALESSANDRO   +8 more
openaire   +4 more sources

8p23.1 duplication syndrome differentiated from copy number variation of the defensin cluster at prenatal diagnosis in four new families [PDF]

, 2010
Background: the 8p23.1 duplication syndrome and copy number variation of the 8p23.1 defensin gene cluster are cytogenetically indistinguishable but distinct at the molecular level.
Emma-Jane Taylor, Liehr, Thomas, Susanne Morlot, Joana Trindade, Ocraft, Kevin, Ana I Paramos, Viv K Maloney, Paramos Ana I, Bunyan Dave, Curtis, Merryl, Claudia Alves, Merryl Curtis, Maloney, Viv K., Dermitzel Anette, Bunyan, Dave, Denise Robinson, Dermitzel, Anette, Thomas Liehr, Alves Claudia, John CK Barber, Kevin Ocraft, Taylor, Emma-Jane, Clare Cooper, Alves, Claudia, Taylor Emma-Jane, Anette Dermitzel, Curtis Merryl, Ocraft Kevin, Barber John CK, Cooper Clare, Paramos, Ana I., Cooper, Clare, Liehr Thomas, Barber, John C.K., Robinson, Denise, Trindade Joana, Morlot, Susanne, Morlot Susanne, Robinson Denise, Maloney Viv K, Dave Bunyan, Trindade, Joana   +41 more
core   +1 more source