Results 21 to 30 of about 42,582 (271)

Isolation and Characterization of Human β-Defensin-3, a Novel Human Inducible Peptide Antibiotic*

Journal of Biological Chemistry, 2001
The growing public health problem of infections caused by multiresistant Gram-positive bacteria, in particularStaphylococcus aureus, prompted us to screen human epithelia for endogenous S. aureus-killing factors. A novel 5-kDa, nonhemolytic antimicrobial
J. Harder, J. Bartels, E. Christophers, J. Schröder   +3 more
semanticscholar   +1 more source

Molecular characterization of a defensin gene from a hard tick, Dermacentor silvarum

Parasites & Vectors, 2015
Background Ticks are distributed worldwide and considered as vectors of many human diseases. Tick defensins, a family of antimicrobial peptides, form the first line of defense against pathogens.
Juanjuan Wang, Gang Bian, Wen Pan, Tingting Feng, Jianfeng Dai   +4 more
doaj   +1 more source

Convergent evolution of defensin sequence, structure and function

Cellular and Molecular Life Sciences, 2017
Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are produced by essentially all eukaryotes and are highly diverse in their sequences and structures.
Thomas M A Shafee, F. T. Lay, T. K. Phan, M. Anderson, M. Hulett   +4 more
semanticscholar   +1 more source

Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma

Mediators of Inflammation, 2015
Background. Innate immune antimicrobial peptides, including β-defensin-1, promote the chemotaxis and activation of several immune cells. The role of β-defensin-1 in asthma and chronic obstructive pulmonary disease (COPD) remains unclear. Methods. Induced
Katherine J. Baines, Thomas K. Wright, Jodie L. Simpson, Vanessa M. McDonald, Lisa G. Wood, Kristy S. Parsons, Peter A. Wark, Peter G. Gibson   +7 more
doaj   +1 more source

Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides

Frontiers in Immunology, 2021
Defects in the mucosal barrier have been associated with metabolic diseases such as obesity and non-alcoholic fatty liver disease (NAFLD). Mice fed a Western-style diet (WSD) develop obesity and are characterized by a diet-induced intestinal barrier ...
Julia Beisner, Louisa Filipe Rosa, Valentina Kaden-Volynets, Iris Stolzer, Claudia Günther, Stephan C. Bischoff   +5 more
doaj   +1 more source

Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells

Nutrients, 2019
The intestine not only plays a role in fundamental processes in digestion and nutrient absorption, but it also has a role in eliminating ingested pathogenic bacteria and viruses.
Akiko Takakuwa, Kiminori Nakamura, Mani Kikuchi, Rina Sugimoto, Shuya Ohira, Y. Yokoi, T. Ayabe   +6 more
semanticscholar   +1 more source

β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development

Scientific Reports, 2017
β-defensin family plays a role in host defense against viral infection, however its role in HCV infection is still unknown. In this study, we demonstrated that β-defensin 1 was significantly reduced in HCV-infected liver specimens.
Yue-Ming Ling, Jin-Yu Chen, Libin Guo, Chen-Yi Wang, Wen-Ting Tan, Qing Wen, Shu-Dong Zhang, Guo-Hong Deng, Yao Lin, Hang Fai Kwok   +9 more
doaj   +1 more source

Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research, 2019
BackgroundSynovial fluid proteins had been applied as diagnostic biomarkers for periprosthetic joint infection (PJI) in recent research papers. Thus, this meta-analysis aimed to estimate the diagnostic efficiency of synovial fluid α-defensin and ...
Yisheng Chen, Xue-ran Kang, J. Tao, Yunpeng Zhang, Chen-ting Ying, Weiwei Lin   +5 more
semanticscholar   +1 more source

Gene Expression in Cucurbita spp. Root and Crown during Phytophthora capsici Infection

Plants, 2021
Phytophtora capsici causes major diseases in cucurbit crops worldwide. In this study, we inoculated this pathogen into Cucurbita pepo subsp. pepo susceptible MUCU-16 and C. moschata tolerant M63. The gene expression of plant pathogenesis-related proteins
Alejandro Ayala-Doñas, Pedro Gómez, Miguel de Cara-García   +2 more
doaj   +1 more source

Plant Defensin Peptides have Antifungal and Antibacterial Activity Against Human and Plant Pathogens.

Phytopathology, 2019
Plant defensins are small, cysteine-rich antimicrobial peptides. These peptides have previously been shown to primarily inhibit the growth of fungal plant pathogens.
A. Sathoff, S. Velivelli, D. Shah, D. Samac   +3 more
semanticscholar   +1 more source