False-Negative Synovial Alpha-Defensin [PDF]
Arthroplasty Today, 2017 We present a case of chronic periprosthetic hip infection diagnosed using the Musculoskeletal Infection Society criteria as the gold standard. The alpha-defensin test was falsely negative.
Adam J Schwartz
exaly +8 more sources
Alleviation of Hepatic Steatosis by Alpha-Defensin Is Associated With Enhanced Lipolysis [PDF]
Medicina (Lithuania), 2023 Background and Objectives: The neutrophilic peptide, alpha-defensin, is considered an evolving risk factor intimately linked with lipid mobilization. It was previously linked to augmented liver fibrosis.
Johnny Amer +2 more
exaly +7 more sources
Predictive Value of Baseline Alpha Defensin Level in Patients With Stable Coronary Artery Disease: A Retrospective Single Center Study [PDF]
IJC Heart and VasculatureBackground: Inflammation plays a central role in atherogenesis. The major neutrophilic peptide alpha-defensin is a promising evolving risk factor for atherosclerosis.
Ariel ROGUIN +2 more
exaly +5 more sources
Inflammatory burden in dialysis patients: the role of alpha defensin [PDF]
Frontiers in ImmunologyIntroductionThe major neutrophilic peptide alpha-defensin plays a pivotal role in atherogenesis. Atherosclerosis is more frequent in dialysis patients, increasingly ascribed to chronic low-grade inflammation.
Maanit Shapira +5 more
doaj +4 more sources
Alpha-Defensin 1: An Emerging Periodontitis Biomarker [PDF]
Diagnostics, 2023 Background: Research on the development of reliable diagnostic targets is being conducted to overcome the high prevalence and difficulty in managing periodontitis.
Jisuk Lee +3 more
doaj +4 more sources
AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis [PDF]
Gut MicrobesAlpha-defensin 1 is a small antimicrobial peptide that acts as the first line of defense against pathogens. It is induced following microbial cues and inflammatory signals in neutrophils and Paneth cells in the small intestine, which suggests that it ...
Manikandan Palrasu +11 more
doaj +3 more sources
Nonoperative Treatment of a Periprosthetic Gout Flare in the Setting of a Positive Alpha-Defensin Result [PDF]
Arthroplasty Today, 2021 Gout is a rare cause of pain after total knee arthroplasty, and its presentation can be difficult to distinguish from a prosthetic joint infection. We describe a patient with left knee pain that had a history of gout and left total knee arthroplasty ...
David S. Phillips, DO +2 more
doaj +3 more sources
It can be unnecessary to combine common synovial fluid analysis and alpha-defensin tests for periprosthetic joint infection diagnosis [PDF]
BMC Musculoskeletal Disorders, 2023 Background Periprosthetic joint infection is a serious complication after total joint arthroplasty. Despite that alpha-defensin was used as diagnostic test in the 2018 ICM (international consensus meeting) criteria, its position in the PJI diagnostic ...
Hao Li +8 more
doaj +2 more sources
Diagnosis of Spinal Infection with Alpha-defensin Lateral Flow Test: A Preliminary Report [PDF]
Spine Surgery and Related Research, 2022 Introduction: The alpha-defensin lateral flow test has been used in periprosthetic joint infection as a diagnostic support tool because of its simplicity and speed. However, the test has not been used to diagnose spinal infections.
Atsuhiro Yoshida +5 more
doaj +2 more sources
Diagnostic Accuracy of Synovial Alpha-Defensin and Histopathology for Periprosthetic Joint Infection: A Validation Study [PDF]
Journal of Orthopaedic Case ReportsIntroduction: Periprosthetic joint infection (PJI) remains one of the most serious complications following total hip and knee arthroplasty, often leading to repeated surgeries, prolonged hospitalization, and poor functional outcomes.
Sina Jamaria +5 more
doaj +2 more sources