Results 31 to 40 of about 909,139 (164)
Human alpha defensin 5 expression in the human kidney and urinary tract. [PDF]
PLoS ONE, 2012 BackgroundThe mechanisms that maintain sterility in the urinary tract are incompletely understood. Recent studies have implicated the importance of antimicrobial peptides (AMP) in protecting the urinary tract from infection.
John David Spencer +7 more
doaj +5 more sources
Human Neutrophil α-Defensins 1–3 Are Upregulated in the Microenvironment of Fibrotic Liver
Medicina, 2023 Background and Objectives: Neutrophil infiltration is an established signature of Non-Alcoholic Fatty Liver Disease (NAFLD) and Steatohepatitis (NASH).
Rami Abu Fanne +8 more
doaj +1 more source
Enteric alpha defensins in norm and pathology [PDF]
Annals of Clinical Microbiology and Antimicrobials, 2012 Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria ...
Lisitsyn, Nikolai A +5 more
openaire +3 more sources
Alpha‐defensins: risk factor for thrombosis in COVID‐19 infection [PDF]
British Journal of Haematology, 2021 SummaryThe inflammatory response to SARS/CoV‐2 (COVID‐19) infection may contribute to the risk of thromboembolic complications. α‐Defensins, antimicrobial peptides released from activated neutrophils, are anti‐fibrinolytic and prothrombotic in vitro and in mouse models.
Suhair Abdeen +12 more
openaire +2 more sources
The Role of Alpha Defensins in Patients with Ankylosing Spondylitis [PDF]
Aktuelle Rheumatologie, 2020 Abstract Objectives Defensins are a family of antimicrobial peptides. Elevated levels of human neutrophil peptides (HNP 1–3) are seen in blood samples of patients with inflammatory bowel disease (IBD) and in many rheumatic diseases. It has been suggested that they may play a significant role in the progression and pathogenesis of these diseases ...
Pelin Oktayoglu +2 more
openaire +1 more source
ANALYTICAL STUDY AND ANTIMICROBIAL ACTIVITY OF ALPHA-DEFENSIN 2 DISSOLVED IN PHARMACOPOEIA BUFFERS WITH DIFFERENT pH [PDF]
, 2020 Human neutrophil peptides (HNPs, alpha-defensins) are a group of six defensins being considered as new antimicrobial drugs because of their multifunctional efficiency against bacteria, viruses and fungi.
Andonova, Lily A. +5 more
core +1 more source
Mìžnarodnij Endokrinologìčnij Žurnal, 2022 Background. The prevalence of metabolic syndrome (MS), a cluster of risk factors for type 2 diabetes mellitus (DM) and coronary artery disease (CAD), is increasing annually.
N.V. Chmyr +4 more
doaj +1 more source
Comparative analysis of the stability features of human alpha-defensins as candidates for the future COVID-19 therapy through molecular dynamics [PDF]
Pharmaciana, 2022 Coronavirus 19 (COVID-19) is still a global health issue to date, SARS-CoV-2 is a novel coronavirus that is responsible for this sickness. The receptor-binding domain of the SARS-CoV-2 virus associates with angiotensin-converting enzyme 2 (ACE-2) and ...
Taufik Muhammad Fakih +2 more
doaj +1 more source
Follicular fluid expression of alpha-defensins and their role in ovulation [PDF]
Journal of Assisted Reproduction and Genetics, 2008 Defensins are cytotoxic peptides and have a well-defined role in host defense. Human alpha defensins 1-3 (HNP1-3) are primarily produced by peripheral neutrophils and constitute about 50% of the azurphil granule protein. Studies have suggested that peripheral neutrophils and the resident neutrophils in the ovary enhance the release of IL-8 and TNF ...
S, Das +4 more
openaire +2 more sources
Distribution of human B-defensin 2, TNF-alpha, IL-1 alpha, IL-6 and IL-8 in psoriatic skin [PDF]
, 2011 Psoriasis is a chronic, inflammatory, proliferative condition of the skin, clinically characterized by red, scaly plaques. Psoriasis has a large and heterogenous genetic and immunologic background with the dysregulation of the host defense system.
Pilmane, Māra +3 more
core +1 more source