Results 41 to 50 of about 909,139 (164)

Computational study on Polydatin with the Human Alpha-Defensins and the Human Beta Defensins evaluated by Blind Molecular Docking method [PDF]

, 2023
In a comprehensive Molecular Docking investigation using Autodock Vina with the Pyrx program, six Human Defensins (Alpha Defensin-1, Alpha Defensin-3, Alpha Defensin-4, Beta-Defensin-1, Beta-Defensin-2, Beta Defensin-3) were studied alongside various ...
Ravagnan, Giampietro, Ferrari, Ivan Vito
core   +1 more source

Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells

BMC Infectious Diseases, 2006
Background We recently showed that beta-defensins have antimicrobial activity against nontypeable Haemophilus influenzae (NTHi) and that interleukin 1 alpha (IL-1 alpha) up-regulates the transcription of beta-defensin 2 (DEFB4 according to new ...
Park Raekil, Takeshita Tamotsu, Pan Huiqi, Lee Haa-Yung, Moon Sung-Kyun, Cha Kiweon, Andalibi Ali, Lim David J   +7 more
doaj   +1 more source

Alpha Defensin: A Diagnostic Accuracy Depending on the Infection Definition Used

The Journal of Arthroplasty, 2020
The purpose of this study was to evaluate the alpha defensin qualitative detection (ADLF) sensitivity and specificity as compared with 3 standard classifications in the diagnostic management of chronic prosthetic joint infections.A multicenter cohort of 136 patients with a painful arthroplasty was classified into either infected or noninfected ...
Huard, Maxime, Detrembleur, Christine, Poilvache, Hervé, Pastor y Geels, Ines, Van Cauter, Maïté, Driesen, Ronald, Yombi, Jean Cyr, Neyt, Jeroen, Cornu, Olivier   +8 more
openaire   +3 more sources

Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis [PDF]

, 2002
Background: beta-Defensins are a newly identified family of antimicrobial peptides that are expressed by epithelia on mucosal surfaces where their production is augmented by infection or inflammation.
Domizio, P., Bajaj-Elliott, M., Ali, R.S., Domizio, P, Maher, L, Fedeli, P, Farthing, MJG, Fedeli, P., M Bajaj-Elliot (16115810), Quinn, AG, Smith, G.V, Quinn, A.G., Ali, RS, P Domizio (16116209), M J Farthing (16115624), Bajaj-Elliott, M, Maher, L., Farthing, M.J.G., P Fedeli (16116206), R S Ali (16116212), Smith, GV, R G Quinn (16116215), G V Smith (16115678), L Maher (9856208)   +23 more
core   +1 more source

Comparative Genomics and Evolution of the Alpha-Defensin Multigene Family in Primates [PDF]

Molecular Biology and Evolution, 2010
Defensin genes encode small cationic antimicrobial peptides that form an important part of the innate immune system. They are divided into three families, alpha (α), beta (β), and theta (), according to arrangement of the disulfide bonding pattern between cysteine residues.
Sabyasachi, Das, Nikolas, Nikolaidis, Hiroki, Goto, Chelsea, McCallister, Jianxu, Li, Masayuki, Hirano, Max D, Cooper   +6 more
openaire   +2 more sources

Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. [PDF]

PLoS ONE, 2010
Defensins are antimicrobial peptides expressed by plants and animals. In mammals there are three subfamilies of defensins, distinguished by structural features: alpha, beta and theta. Alpha and beta-defensins are linear peptides with broad anti-microbial
Aprille Seidel, Ying Ye, Lesley R de Armas, Maira Soto, William Yarosh, Renee A Marcsisin, Dat Tran, Michael E Selsted, David Camerini   +8 more
doaj   +1 more source

Alpha Defensins 1, 2, and 3 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Objectives— α-Defensins are natural antibiotics made by neutrophils that have been reported to modulate cholesterol metabolism and vascular function; however, their role in vivo remains largely unknown.
Abel, López-Bermejo, Berta, Chico-Julià, Antoni, Castro, Mònica, Recasens, Eduardo, Esteve, Josefina, Biarnés, Roser, Casamitjana, Wifredo, Ricart, José-Manuel, Fernández-Real   +8 more
openaire   +2 more sources

Prognostic role of alpha defensin in predicting periprocedural major myocardial injury following elective percutaneous coronary intervention

American Heart Journal Plus
Background: Periprocedural major myocardial injury (pMMI) remains a frequent complication of elective percutaneous coronary intervention (PCI) and is incompletely explained by procedural complexity or ischemic burden alone.
A.A. Higazi, M. Shapira, I. Abumouch, E. Maraga, N. Amsalem, R. Abu Fanne   +5 more
doaj   +1 more source

Determinants of Mouse Alpha‐Defensin Bactericidal Activity

The FASEB Journal, 2006
Mouse Paneth cell cryptdins are expressed as inactive propeptides and are activated upon proteolysis by MMP‐7. MMP‐7 cleavage sites Ser 43 ↓ Ile 44 , Ala 53 ↓ Leu 54 , and ...
Colby Sanford Weeks, Hiroki Tanabe, Steve P. Crampton, Melanie J. Cocco, Andre J. Ouellette   +4 more
openaire   +1 more source

Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection

International Journal of Immunopathology and Pharmacology, 2018
Synovial fluid analysis for diagnosis of prosthetic joint infections has gained increasing interest in the recent past when markers more specific for these infections than the serum ones have been identified.
Elena De Vecchi, Carlo Luca Romanò, Roberta De Grandi, Laura Cappelletti, Francesca Villa, Lorenzo Drago   +5 more
doaj   +1 more source