Results 51 to 60 of about 909,139 (164)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax)

Pharmaceuticals, 2021
Beta-defensins consist in a group of cysteine-rich antimicrobial peptides (AMPs), widely found throughout vertebrate species, including teleost fish, with antimicrobial and immunomodulatory activities.
Carolina Barroso, Pedro Carvalho, José F. M. Gonçalves, Pedro N. S. Rodrigues, João V. Neves   +4 more
doaj   +1 more source

Sequence analysis of a 212 kb defensin gene cluster on ECA 27q17

, 2006
Defensins are a family of evolutionary ancient antimicrobial peptides consisting of three sub-families: alpha-, beta- and theta-defensins. This investigation was focused on the genomic characterization of equine beta-defensins and the investigation of ...
Paul, Sven, Kuiper, Heidi, Looft, Christian, Distl, Ottmar, Chowdhary, Bhanu P, Leeb, Tosso, Philipp, Ute, Regenhard, Petra   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

In silico docking analysis of beta-defensin 20 against cation channel sperm-associated protein 1–4 to predict its role in the sperm maturation

Asian Journal of Andrology, 2023
Beta-defensin 20 (DEFB20) is widely expressed in the epididymis with gene features involved in epididymal sperm maturation. However, the action mechanism and function of DEFB20 in sperm maturation are still unclear.
Luluk Yunaini, Linda Erlina, Fadilah Fadilah, Dwi Ari Pujianto   +3 more
doaj   +1 more source

Insights into alpha-defensin modulation of non-enveloped viral infection [PDF]

, 2023
Thesis (Ph.D.)--University of Washington, 2023Alpha-defensins are small antimicrobial peptides that play a crucial role in innate immunity across various mammalian species.
Hu, Ciara Tipping
core  

Expression and clinical significance of defensin alpha 6 in colorectal cancer [PDF]

Korean Journal of Clinical Oncology, 2016
Purpose Defensin alpha 6 (DEFA6) is cationic short peptide with known functional activities in innate antimicrobial immunity. DEFA6 is also highly expressed in colorectal cancer tissue.
Saengjin Park, Taesung Ahn, Hyunyong Lee, Dong Jun Jeong, Hae Il Jeong, Myoung Won Son, Moon Soo Lee, Moo-Jun Baek   +7 more
doaj   +1 more source

Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization.

PLoS Pathogens, 2010
Defensins are effectors of the innate immune response with potent antibacterial activity. Their role in antiviral immunity, particularly for non-enveloped viruses, is poorly understood.
Jason G Smith, Mariena Silvestry, Steffen Lindert, Wuyuan Lu, Glen R Nemerow, Phoebe L Stewart   +5 more
doaj   +1 more source

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis [PDF]

, 2009
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease.
Koglin, Sarah, Ulrich Zügel, Thomas Ruzicka, Büchau Amanda, Dombrowski, Yvonne, Zügel, Ulrich, Steinmeyer, Andreas, Jürgen Schauber, Schauber, Jürgen, Büchau, Amanda, Sarah Koglin, Steinmeyer Andreas, Bradac, Eva, Mark Peric, Schauber Jürgen, Koglin Sarah, Amanda Büchau, Zügel Ulrich, Yvonne Dombrowski, Eva Bradac, Katrin Gross, Peric Mark, Gross, Katrin, Dombrowski Yvonne, Peric, Mark, Andreas Steinmeyer, Dombrowski, Yvonne; id_orcid, Bradac Eva, Groß Katrin, Ruzicka, Thomas, Ruzicka Thomas   +30 more
core   +2 more sources

Accurate measurement of gene copy number for human alpha-defensin DEFA1A3 [PDF]

BMC Genomics, 2013
Abstract Background Multi-allelic copy number variants include examples of extensive variation between individuals in the copy number of important genes, most notably genes involved in immune function. The definition of this variation, and analysis of its impact on function, has been hampered by the technical ...
Khan, Fayeza F., Carpenter, Danielle, Mitchell, Laura, Mansouri, Omniah, Black, Holly A., Tyson, Jess, Armour, John A.L.   +6 more
openaire   +3 more sources