Results 71 to 80 of about 909,139 (164)

Raised plasma concentrations of alpha-defensins in patients with idiopathic pulmonary fibrosis [PDF]

Thorax, 2002
Neutrophils are thought to play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Human neutrophils contain antimicrobial and cytotoxic peptides in the azurophil granules which belong to a family of mammalian neutrophil peptides named alpha-defensins.
H, Mukae, H, Iiboshi, M, Nakazato, T, Hiratsuka, M, Tokojima, K, Abe, J, Ashitani, J, Kadota, S, Matsukura, S, Kohno   +9 more
openaire   +2 more sources

Expression of defensin antimicrobial peptides in the peritoneal cavity of patients on peritoneal dialysis

, 2001
Copyright © 2001 by International Society for Peritoneal DialysisOBJECTIVE: To investigate the expression and regulation of defensins in the peritoneal cavity of peritoneal dialysis (PD) patients.
Atkins, G., Zarrinkalam, K., Faull, R., Stanley, J., Leavesley, D.   +4 more
core   +1 more source

Serum defensin levels in patients with systemic sclerosis

Advances in Rheumatology, 2020
Background Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and lung as well as involvement of kidney, gastrointestinal system and heart. Aetiology and exact mechanism of disease is poorly understood.
Tugce Emiroglu Gedik, Hamit Kucuk, Berna Goker, Seminur Haznedaroglu, Hatice Pasaoglu, Ozkan Varan, Mehmet Akif Ozturk, Ozge Tugce Pasaoglu, Abdurrahman Tufan   +8 more
doaj   +1 more source

Soluble FcγRIIIb (CD16b) and Alpha Defensin as Markers of Neutrophils Activation in Periodontal Disease

Ibn Al-Haitham Journal for Pure and Applied Sciences
Neutrophils in saliva cause tissue death in inflammatory disorders, including periodontal disease. Identifying biomarkers for neutrophil mediators is crucial for accurate diagnosis in periodontics research.
Fatima Sabah Jasim, Batool Hassan Al-Ghurabi   +1 more
doaj   +1 more source

The Putative Role of Human Peritoneal Adipocytes in the Fight against Bacteria: Synthesis of the Antimicrobial Active Peptide DEFA1-3 [PDF]

, 2010
Background: Spontaneous peritonitis is a rather rare event, even in peritoneal dialysis (PD). As defensins are natural antimicrobial peptides, we hypothesized that adipocytes as the major constituents of the omentum could play an important role in ...
Paslakis, Georgios, Schmid, Holger, Schloendorff, Detlef, Keuneke, Christian, Schroppel, Bernd, Groene, Hermann-Josef   +5 more
core   +1 more source

The Oligomeric State of Human Alpha-Defensin 1 in Solution [PDF]

Biophysical Journal, 2014
Defensins are small (18-45 amino acids) proteins present in organisms from plants to humans. They function as host defense peptides, assisting the immune system cells in killing phagocytosed bacteria, and are also active against fungi and viruses. The defensins mode of action is membrane permeabilization - forming fatal, pore-like membrane defects in ...
openaire   +1 more source

Paneth cell alpha-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice

, 2020
Crohn's disease (CD) is an intractable inflammatory bowel disease, and dysbiosis, disruption of the intestinal microbiota, is associated with CD pathophysiology.
Ohira, Shuya, Sugimoto, Rina, Shinozaki, Ryuga, Nakamura, Kiminori, Yoshii, Aki, Nakamura, Shunta, Yokoi, Yuki, Ayabe, Tokiyoshi, Shimizu, Yu, Kikuchi, Mani   +9 more
core   +1 more source

Plectasin, First Animal Toxin-Like Fungal Defensin Blocking Potassium Channels through Recognizing Channel Pore Region

Toxins, 2015
The potassium channels were recently found to be inhibited by animal toxin-like human β-defensin 2 (hBD2), the first defensin blocker of potassium channels. Whether there are other defensin blockers from different organisms remains an open question. Here,
Fang Xiang, Zili Xie, Jing Feng, Weishan Yang, Zhijian Cao, Wenxin Li, Zongyun Chen, Yingliang Wu   +7 more
doaj   +1 more source

Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse

Frontiers in Immunology, 2020
Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6.
Kiminori Nakamura, Kiminori Nakamura, Yuki Yokoi, Rie Fukaya, Shuya Ohira, Ryuga Shinozaki, Takuto Nishida, Mani Kikuchi, Tokiyoshi Ayabe, Tokiyoshi Ayabe   +9 more
doaj   +1 more source

Human alpha defensin CNV haplotype diversity [PDF]

Humans have highly variable number of alpha defensin genes, with between 3-16 diploid copies. Alpha-defensin genes have important roles in human innate immunity and diseases.
Xu, Xiao
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