Results 61 to 70 of about 909,139 (164)
Data_Sheet_1_β-defensin-4 as an endogenous biomarker in cows with mastitis.docx
, 2023 IntroductionDefensins are peptides with antimicrobial and immunomodulatory effects. Their concentration could be altered during infections and thus provide information on the prognosis and course of the disease.
Anneke Fischer (14835181) +2 more
core +1 more source
An update on the use of alpha-defensin for the diagnosis of prosthetic joint infection: a narrative review [PDF]
The Egyptian Orthopaedic JournalBackground: The diagnosis of prosthetic joint infection (PJI) remains a clinical challenge. Recently, there has been growing interest in synovial fluid biomarkers, particularly alpha-defensin (AD), as tools to aid in PJI diagnosis.Methods: This narrative
Mohamed Askar +3 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Understanding of the basis for severity and fatal outcome of SARS-CoV-2 infection is of paramount importance for developing therapeutic options and identification of prognostic markers.
Shubham Shrivastava +6 more
doaj +1 more source
The Journal of biological chemistry, 2003 The bactericidal activity of mouse alpha-defensins (cryptdins) requires proteolytic activation of inactive precursors by matrix metalloproteinase-7 (matrilysin, EC, MMP-7(a)). To investigate mechanisms of cryptdin-4 (Crp4) peptide interactions with membrane bilayers and to determine whether MMP-7-mediated proteolysis activates the membrane disruptive ...
Donald P, Satchell +5 more
openaire +2 more sources
Conformational landscape and pathway of disulfide bond reduction of human alpha defensin [PDF]
Protein Science, 2015 AbstractHuman alpha defensins are a class of antimicrobial peptides with additional antiviral activity. Such antimicrobial peptides constitute a major part of mammalian innate immunity. Alpha defensins contain six cysteines, which form three well defined disulfide bridges under oxidizing conditions.
Joost Snijder +5 more
openaire +3 more sources
Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action
, 2023 Whooping cough is a severe childhood disease, caused by the bacterium Bordetella pertussis, which releases pertussis toxin (PT) as a major virulence factor.
Katharina Ernst +12 more
core +1 more source
Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen [PDF]
Reproductive Biology and Endocrinology, 2011 Background: During pregnancy the immune system of the mother must protect any activation that may negatively affect the fetus. Changes in susceptibility to infection as well as resolution of some autoimmune disorders represent empirical evidence for pregnancy related alterations in immunity. Sex hormones reach extremely high levels during pregnancy and
Sperling Rhoda +5 more
openaire +4 more sources
Bone & Joint ResearchAims: The diagnosis of periprosthetic joint infection (PJI) remains a challenge, as no single diagnostic test shows high diagnostic accuracy. Recently, the measurement of synovial biomarkers has shown promising results.
Martina Maritati +3 more
doaj +1 more source
The Journal of biological chemistry, 2009 Paneth cells are a secretory epithelial lineage that release dense core granules rich in host defense peptides and proteins from the base of small intestinal crypts. Enteric alpha-defensins, termed cryptdins (Crps) in mice, are highly abundant in Paneth cell secretions and inherently resistant to proteolysis.
Jennifer R, Mastroianni +1 more
openaire +1 more source
Alpha Defensins Genes and Vulvovaginal Candidiasis: A Study of Cases
Open Journal of Obstetrics and Gynecology, 2015 Objective: To evaluate the alpha-defensin (α-DF) genes polymorphism in women with vulvovaginal candidiasis and recurrence. Methods: This observational study included clinical vaginal secretion samples collected over four years from 88 women, ranging in age from 18 to 65 years, from medical centers of Sao Paulo and Mogi das Cruzes, Brazil. Thirty-six of
Humberto F. Boatto +6 more
openaire +2 more sources