Results 11 to 20 of about 42,582 (271)

Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis

Frontiers in Immunology, 2020
Defensins represents an integral part of the innate immune system serving to ward off potential pathogens and to protect the intestinal barrier from microbial encroachment.
L. Koeninger, Nicole S. Armbruster, K. Brinch, Søren Kjaerulf, B. Andersen, Carolin Langnau, S. Autenrieth, D. Schneidawind, E. Stange, N. Malek, P. Nordkild, B. Jensen, J. Wehkamp   +12 more
semanticscholar   +1 more source

Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota

Scientific Reports, 2023
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by fibrosis that develops from fatty liver. Disruption of intestinal microbiota homeostasis, dysbiosis, is associated with fibrosis development in NASH. An antimicrobial peptide
Shunta Nakamura, Kiminori Nakamura, Yuki Yokoi, Yu Shimizu, Shuya Ohira, Mizu Hagiwara, Zihao Song, Li Gan, Tomoyasu Aizawa, Daigo Hashimoto, Takanori Teshima, Andre J. Ouellette, Tokiyoshi Ayabe   +12 more
doaj   +1 more source

Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice

Life Science Alliance, 2020
This study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.
Yu Shimizu, Kiminori Nakamura, A. Yoshii, Y. Yokoi, Mani Kikuchi, Ryuga Shinozaki, Shunta Nakamura, Shuya Ohira, Rina Sugimoto, T. Ayabe   +9 more
semanticscholar   +1 more source

Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions

Antibiotics, 2023
Cryptdin-4 (crp4) is an enteric α-defensin derived from mice, and is a main mediator of immunity to oral infections and a determinant of the composition of the intestinal microbiota.
Yi Wang, Yuchi Song, Shaonan Yan, Rina Hiramine, Yuki Ohnishi, Yuki Yokoi, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe, Tomoyasu Aizawa   +9 more
doaj   +1 more source

Immune Responses of the Black Soldier Fly Hermetia illucens (L.) (Diptera: Stratiomyidae) Reared on Catering Waste

Life, 2023
The black soldier fly (BSF), Hermetia illucens L. (Diptera: Stratiomyidae), has a great bioconversion potential and ability to develop on diverse substrates.
Valentina Candian, Marco Meneguz, Rosemarie Tedeschi   +2 more
doaj   +1 more source

A defensin-like protein drives cadmium efflux and allocation in rice

Nature Communications, 2018
Pollution by heavy metals limits the area of land available for cultivation of food crops. A potential solution to this problem might lie in the molecular breeding of food crops for phytoremediation that accumulate toxic metals in straw while producing ...
Jin-song Luo, Jing Huang, D. Zeng, Jia-Shi Peng, Guo-bin Zhang, Hai-Ling Ma, Yuan Guan, Hongying Yi, Yanlei Fu, B. Han, Hong-Xuan Lin, Q. Qian, Jiming Gong   +12 more
semanticscholar   +1 more source

Potential biochemical markers of chronic bronchitis and bronchial asthma. Current state of the problem

Сибирский научный медицинский журнал, 2020
The literature review, according to recent publications, systematizes modern ideas about new biochemical markers of bronchopulmonary pathology, namely chronic obstructive pulmonary disease, chronic bronchitis and bronchial asthma.
E. A. Kurtukov, Yu. I. Ragino
doaj   +1 more source

Age-Related Expression of IFN-λ1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals

Frontiers in Immunology, 2021
SARS-CoV-2 coronavirus infection induces heterogeneous symptoms, ranging from asymptomatic to lethal forms. Severe forms usually occur in the elderly and/or individuals with comorbidities.
Charly Gilbert, Charly Gilbert, Caroline Lefeuvre, Caroline Lefeuvre, Laurence Preisser, Adeline Pivert, Adeline Pivert, Raffaella Soleti, Simon Blanchard, Simon Blanchard, Yves Delneste, Yves Delneste, Alexandra Ducancelle, Alexandra Ducancelle, Dominique Couez, Pascale Jeannin, Pascale Jeannin   +16 more
doaj   +1 more source

Avian defensins

Veterinary Immunology and Immunopathology, 2008
Modulation of defensin expression may be one way to improve animal health and to reduce zoonotic diseases. Defensins are small, cationic, and amphipathic cysteine-rich antibiotic peptides found in plants, insects, mammals and birds. Whereas alpha- and theta-defensins appear to be absent in birds, several beta-defensins have been isolated from avian ...
van Dijk, A., Veldhuizen, E.J.A., Haagsman, H.P.   +2 more
openaire   +4 more sources

Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture

Viruses, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the newly emergent causative agent of coronavirus disease-19 (COVID-19), has resulted in more than two million deaths worldwide since it was first detected in 2019.
Allison Bakovic, Kenneth Risner, Nishank Bhalla, Farhang Alem, Theresa L. Chang, Warren K. Weston, Jane A. Harness, Aarthi Narayanan   +7 more
doaj   +1 more source