Results 41 to 50 of about 37,059 (248)

Molecular characterization of grouper β-defensin.

, 2013
(A) Nucleotide and deduced amino acid sequences of grouper β-defensin. The signal peptide is underlined. (B) Multiple alignment of grouper β-defensin amino acid sequences with other β-defensin proteins from fish.
Yang Wang (5921), Qi-Ya Zhang (311840), Zhi Li (72309), Jiu-Gang Zhao (358488), Jian-Fang Gui (259030), Jun-Yan Jin (358487), Li Zhou (54356)   +6 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Defensins in Viral Infections [PDF]

Journal of Innate Immunity, 2009
Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses.
Jian, Ding, Yi-Ying, Chou, Theresa L, Chang   +2 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Antimicrobial peptides and other potential biomarkers of critical illness in SARS‐CoV‐2 patients with acute kidney injury. AMPAKI‐CoV study

Physiological Reports
Antimicrobial peptides (AMPs) constitute a complex network of 10–100 amino acid sequence molecules widely distributed in nature. While over 300 AMPs have been described in mammals, cathelicidins and defensins remain the most extensively studied.
Lucas Ferreira Theotonio dos Santos, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Heraldo Possolo deSouza, Fabiano Pinheiro da Silva   +4 more
doaj   +1 more source

Predictive value of baseline alpha defensin level in patients with stable coronary artery disease: A retrospective single center study

International Journal of Cardiology: Heart & Vasculature
Background: Inflammation plays a central role in atherogenesis. The major neutrophilic peptide alpha-defensin is a promising evolving risk factor for atherosclerosis.
Maanit Shapira, Ariel Roguin, Ibraheem Fayad, Lina Medlij, Aysha khateeb, Dema Egbaria, Naama Amsalem, Rami Abu Fanne   +7 more
doaj   +1 more source

Buzz Kill: Function and Proteomic Composition of Venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae)

Toxins, 2018
Assassin flies (Diptera: Asilidae) inject paralysing venom into insect prey during hunting, but their venoms are poorly characterised in comparison to those produced by spiders, scorpions, or hymenopteran insects.
Andrew A. Walker, James Dobson, Jiayi Jin, Samuel D. Robinson, Volker Herzig, Irina Vetter, Glenn F. King, Bryan G. Fry   +7 more
doaj   +1 more source

Defensin-lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

, 2022
Defensins are a class of host defence peptides (HDPs) that often harbour antimicrobial and anticancer activities, making them attractive candidates as novel therapeutics.
Marc Kvansakul (9487712), Matthew Hein (9475154), Thanh Phan (9478205), Fung Lay (9493340), Kha Phan (9478205), Mark Hulett (9487877)   +5 more
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin

Toxins, 2018
On the basis of the evolutionary relationship between scorpion toxins targeting K+ channels (KTxs) and antibacterial defensins (Zhu S., Peigneur S., Gao B., Umetsu Y., Ohki S., Tytgat J.
Shangfei Zhang, Bin Gao, Xueli Wang, Shunyi Zhu   +3 more
doaj   +1 more source