Results 31 to 40 of about 42,582 (271)
Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32
Frontiers in Microbiology, 2019 Pathogenic microbes are developing resistance to established antibiotics, making the development of novel antimicrobial molecules paramount. One major resource for discovery of antimicrobials is the arsenal of innate immunity molecules that are part of ...
Bomai Kerenga +15 more
semanticscholar +1 more source
Artificial β-defensin based on a minimal defensin template
Biochemical Journal, 2009 We have designed and chemically synthesized an artificial β-defensin based on a minimal template derived from the comparative analysis of over 80 naturally occurring sequences. This molecule has the disulfide-bridged β-sheet core structure of natural β-defensins and shows a robust salt-sensitive antimicrobial activity against bacteria and yeast, as ...
ANTCHEVA, Nikolinka +8 more
openaire +4 more sources
Science Advances, 2018 Human β-defensin 2 permeabilizes and kills fungal cells by specifically targeting the important plasma membrane lipid PIP2. Human defensins belong to a subfamily of the cationic antimicrobial peptides and act as a first line of defense against invading ...
M. Järvå +5 more
semanticscholar +1 more source
Scientific Reports, 2017 Royal jelly (RJ) has successfully been used as a remedy in wound healing. RJ has multiple effects, including antibacterial, anti-inflammatory and immunomodulatory activities, in various cell types. However, no component(s) (other than antibacterial) have
M. Bucekova +8 more
semanticscholar +1 more source
Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints
Angewandte Chemie, EarlyView.We demonstrate a new platform for antimicrobial peptide identification by combining polydiacetylene, hyperspectral imaging, and deep learning. The trained model classifies distinct spectral fingerprints into 14 peptide classes with 96.79% accuracy, revealing previously hidden molecular information beyond conventional colorimetric sensing.
Jiali Chen +4 more
wiley +2 more sources
Antimicrobial peptides in pregnant women with TORCH infections
Акушерство, гинекология и репродукция, 2019 Introduction. Analysis for TORCH infections is ordered to simultaneously detect several common infections: Toxoplasmosis, Other infections (syphilis, hepatitis B, chickenpox, Epstein-Barr virus, parvovirus and some others), Rubella, Cytomegalovirus and ...
G. V. Narimanova +3 more
doaj +1 more source
Química Nova, 2004 The structure and hydration of the HNP-3 have been derived from molecular dynamics data using root mean square deviation, radial and energy distributions. Three antiparallel beta sheets were found to be preserved.
Adriana M. Namba, Léo Degrève
doaj +1 more source
Frontiers in Immunology, 2020 Host defense peptides, abundantly secreted by colonic epithelial cells and leukocytes, are proposed to be critical components of an innate immune response in the colon against enteropathogenic bacteria, including Shigella spp., Salmonella spp ...
Graham A. D. Blyth +3 more
doaj +1 more source
Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5
Frontiers in Immunology, 2023 IntroductionThe mechanism underlying radiation-induced gut microbiota dysbiosis is undefined. This study examined the effect of radiation on the intestinal Paneth cell α-defensin expression and its impact on microbiota composition and mucosal tissue ...
Pradeep K. Shukla +12 more
doaj +1 more source
PLoS Pathogens, 2017 Ever since the discovery of endogenous host defense antimicrobial peptides it has been discussed how these evolutionary conserved molecules avoid to induce resistance and to remain effective.
Judith Raschig +8 more
semanticscholar +1 more source