Results 31 to 40 of about 22,371 (222)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Research progress on anti-mycobacterial effect of mammal defensins
Siliao yanjiu, 2022 Mammalian defencins are cationic peptides with antimicrobial activity produced by a variety of cells. They are divided into α-defencins, β-defencins and θ-defencins, which exert antimicrobial effects mainly by increasing the permeability of bacterial ...
KANG Jing-jing +5 more
doaj
Mechanisms and regulation of defensins in host defense
Signal Transduction and Targeted Therapy, 2023 As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to host defense.
Jie Fu +5 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2021 Defensins are small proteins, usually ranging from 3 to 6 kDa, amphipathic, disulfide-rich, and with a small or even absent hydrophobic core. Since a hydrophobic core is generally found in globular proteins that fold in an aqueous solvent, the peculiar ...
Mariana H. Moreira +3 more
doaj +1 more source
Advanced Science, EarlyView.Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu +5 more
wiley +1 more source
Advanced Science, EarlyView.The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt +16 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Defensins of Grasses: A Systematic Review
Biomolecules, 2020 The grass family (Poaceae) is one of the largest families of flowering plants, growing in all climatic zones of all continents, which includes species of exceptional economic importance.
Tatyana I. Odintsova +2 more
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International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Introduction Chronic rhinosinusitis (CRS) is an inflammatory disease with many different contributing factors, including bacterial infection. CRS patients are typically managed with medical therapies; however, these treatments frequently fail, leaving surgery as the only viable option.
Sintayehu Ambachew +8 more
wiley +1 more source
Antifungal defensins and their role in plant defense
Frontiers in Microbiology, 2014 Since the beginning of the 90’s lots of cationic plant, cysteine-rich antimicrobial peptides (AMP) have been studied. However, Broekaert only coined the term plant defensin in 1995, after comparison of a new class of plant antifungal peptides with known
Ariane eLacerda +4 more
doaj +1 more source