Results 21 to 30 of about 1,130 (180)
Defensins: A Double-Edged Sword in Host Immunity
Frontiers in Immunology, 2020 Defensins are a major family of host defense peptides expressed predominantly in neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted immunomodulatory functions have been extensively studied, cementing their role in ...
Dan Xu, Wuyuan Lu
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Reproductive Biology and Endocrinology, 2006 Background beta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. The majority of beta-defensins identified in humans are predominantly expressed in the male reproductive tract and have roles in non-immunological
French Frank S +5 more
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Artificial β-defensin based on a minimal defensin template
Biochemical Journal, 2009 We have designed and chemically synthesized an artificial β-defensin based on a minimal template derived from the comparative analysis of over 80 naturally occurring sequences. This molecule has the disulfide-bridged β-sheet core structure of natural β-defensins and shows a robust salt-sensitive antimicrobial activity against bacteria and yeast, as ...
ANTCHEVA, Nikolinka +8 more
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Egyptian Rheumatology and Rehabilitation, 2020 Background Behcet’s disease (BD) is associated with uveitis, oral ulcers, genital ulcers and arthritis. Enhanced activity of innate immunity components, such as neutrophils, natural killer (NK) cells and endothelial cells, is a prominent feature of BD ...
Reham M. Shaat +4 more
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Functional Insights From the Evolutionary Diversification of Big Defensins
Frontiers in Immunology, 2020 Big defensins are antimicrobial polypeptides believed to be the ancestors of β-defensins, the most evolutionary conserved family of host defense peptides (HDPs) in vertebrates.
Marco Gerdol +5 more
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Defensins in Viral Infections [PDF]
Journal of Innate Immunity, 2009 Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses.
Jian, Ding +2 more
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β-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios
Asian Journal of Andrology, 2016 β-defensins are components of host defense, with antimicrobial and pleiotropic immuno-modulatory properties. Research over the last 15 years has demonstrated abundant expression of a variety of β-defensins in the postnatal epididymis of different species.
Camilla M Ribeiro +3 more
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Computational and Structural Biotechnology Journal, 2021 Defensins are small proteins, usually ranging from 3 to 6 kDa, amphipathic, disulfide-rich, and with a small or even absent hydrophobic core. Since a hydrophobic core is generally found in globular proteins that fold in an aqueous solvent, the peculiar ...
Mariana H. Moreira +3 more
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Defensins of Grasses: A Systematic Review
Biomolecules, 2020 The grass family (Poaceae) is one of the largest families of flowering plants, growing in all climatic zones of all continents, which includes species of exceptional economic importance.
Tatyana I. Odintsova +2 more
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Mechanisms and regulation of defensins in host defense
Signal Transduction and Targeted Therapy, 2023 As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to host defense.
Jie Fu +5 more
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