Results 21 to 30 of about 28,067 (241)
The Role of Defensins in HIV Pathogenesis
Mediators of Inflammation, 2017 Profound loss of CD4+ T cells, progressive impairment of the immune system, inflammation, and sustained immune activation are the characteristics of human immunodeficiency virus-1 (HIV-1) infection.
Barcley T. Pace +3 more
doaj +2 more sources
Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. [PDF]
PLoS ONE, 2010 Defensins are antimicrobial peptides expressed by plants and animals. In mammals there are three subfamilies of defensins, distinguished by structural features: alpha, beta and theta. Alpha and beta-defensins are linear peptides with broad anti-microbial
Aprille Seidel +8 more
doaj +3 more sources
Defensins: The Case for Their Use against Mycobacterial Infections [PDF]
Journal of Immunology Research, 2016 Human tuberculosis remains a huge global public health problem with an estimated 1/3rd of the population being infected. Defensins are antibacterial cationic peptides produced by a number of cell types, most notably neutrophil granulocytes and epithelial
Haodi Dong +4 more
doaj +2 more sources
Clinical Immunology Newsletter, 1987 Abstract: Defensins are a family of small, variably cationic proteins which are highly abundant in the granules of mammalian phagocytes. Three defensins, HNP‐1, 2, and 3, comprise 30–50% of total protein in azurophil granules of human neutrophils. Some defensins are broadly antimicrobial, antiviral and cytotoxic, while others are chemotactic, opsonic,
T, Ganz, M E, Selsted, R I, Lehrer
openaire +2 more sources
BioMed Research International, 2014 Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues.
Xie, Guo-Hao +3 more
openaire +2 more sources
Expression of defensins in non-infected araneomorph spiders [PDF]
, 2010 Defensins are a major family of antimicrobial peptides found throughout the phylogenetic tree. From the spider species: Cupiennius salei, Phoneutria reidyi, Polybetes pythagoricus, Tegenaria atrica, and Meta menardi, defensins belonging to the 'ancestral'
Baumann, Tommy +8 more
core +3 more sources
Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis [PDF]
, 2002 Background: beta-Defensins are a newly identified family of antimicrobial peptides that are expressed by epithelia on mucosal surfaces where their production is augmented by infection or inflammation.
Domizio, P. +23 more
core +1 more source
Increased expression and levels of human β defensins (hBD2 and hBD4) in adults with dental caries
Journal of Health Sciences, 2013 Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two ...
Girolamo Jose Barrera +4 more
doaj +3 more sources
The Putative Role of Human Peritoneal Adipocytes in the Fight against Bacteria: Synthesis of the Antimicrobial Active Peptide DEFA1-3 [PDF]
, 2010 Background: Spontaneous peritonitis is a rather rare event, even in peritoneal dialysis (PD). As defensins are natural antimicrobial peptides, we hypothesized that adipocytes as the major constituents of the omentum could play an important role in ...
Paslakis, Georgios +5 more
core +1 more source
Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics
Molecules, 2017 Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and high serum stability, which is useful to develop and design novel antimicrobial agents.
Annarita Falanga +6 more
doaj +1 more source