Results 21 to 30 of about 22,371 (222)
Antifungal Plant Defensins: Mechanisms of Action and Production
Molecules, 2014 Plant defensins are small, cysteine-rich peptides that possess biological activity towards a broad range of organisms. Their activity is primarily directed against fungi, but bactericidal and insecticidal actions have also been reported.
Kim Vriens +2 more
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Artificial β-defensin based on a minimal defensin template
Biochemical Journal, 2009 We have designed and chemically synthesized an artificial β-defensin based on a minimal template derived from the comparative analysis of over 80 naturally occurring sequences. This molecule has the disulfide-bridged β-sheet core structure of natural β-defensins and shows a robust salt-sensitive antimicrobial activity against bacteria and yeast, as ...
ANTCHEVA, Nikolinka +8 more
openaire +4 more sources
Defensins: A Double-Edged Sword in Host Immunity
Frontiers in Immunology, 2020 Defensins are a major family of host defense peptides expressed predominantly in neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted immunomodulatory functions have been extensively studied, cementing their role in ...
Dan Xu, Wuyuan Lu
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Reproductive Biology and Endocrinology, 2006 Background beta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. The majority of beta-defensins identified in humans are predominantly expressed in the male reproductive tract and have roles in non-immunological
French Frank S +5 more
doaj +1 more source
Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints
Angewandte Chemie, EarlyView.We demonstrate a new platform for antimicrobial peptide identification by combining polydiacetylene, hyperspectral imaging, and deep learning. The trained model classifies distinct spectral fingerprints into 14 peptide classes with 96.79% accuracy, revealing previously hidden molecular information beyond conventional colorimetric sensing.
Jiali Chen +4 more
wiley +2 more sources
Egyptian Rheumatology and Rehabilitation, 2020 Background Behcet’s disease (BD) is associated with uveitis, oral ulcers, genital ulcers and arthritis. Enhanced activity of innate immunity components, such as neutrophils, natural killer (NK) cells and endothelial cells, is a prominent feature of BD ...
Reham M. Shaat +4 more
doaj +1 more source
Functional Insights From the Evolutionary Diversification of Big Defensins
Frontiers in Immunology, 2020 Big defensins are antimicrobial polypeptides believed to be the ancestors of β-defensins, the most evolutionary conserved family of host defense peptides (HDPs) in vertebrates.
Marco Gerdol +5 more
doaj +1 more source
β-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios
Asian Journal of Andrology, 2016 β-defensins are components of host defense, with antimicrobial and pleiotropic immuno-modulatory properties. Research over the last 15 years has demonstrated abundant expression of a variety of β-defensins in the postnatal epididymis of different species.
Camilla M Ribeiro +3 more
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DEFENSINS-a AT AN EARLY AGE IN RATS WITH ACUTE SOMATIC PAIN
RUDN Journal of Medicine, 2019 This article presents the results of studies on the reaction of α-defensins to acute somatic pain in newborn rats and in the early puberty period. Studies were carried out on white mongrel rats for three hours after pain exposure.
I. M. Bykov, V. V. Alekseev
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Defensins in Viral Infections [PDF]
Journal of Innate Immunity, 2009 Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses.
Jian, Ding +2 more
openaire +2 more sources