Results 21 to 30 of about 42,072 (251)

A pilot study for evaluating the feasibility of using alpha-defensin to support the diagnosis of ventriculitis

International Journal of Infectious Diseases, 2023
Objectives: Nosocomial ventriculitis is a difficult infectious condition to diagnose given that typical cerebral spinal fluid (CSF) parameters, commonly used in the diagnosis of meningitis, lack sensitivity and specificity in nosocomial ventriculitis ...
James B. Doub
doaj   +1 more source

Alpha-defensins inhibit ERK/STAT3 signaling during monocyte-macrophage differentiation and impede macrophage function

Respiratory Research, 2023
Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder associated with a 5–tenfold decrease in lung levels of alpha-1-antitrypsin (AAT) and an increased risk for obstructive lung disease.
Jungnam Lee, Naweed Mohammad, Yuanqing Lu, Regina Oshins, Alek Aranyos, Mark Brantly   +5 more
doaj   +1 more source

Intestinal α-Defensins Play a Minor Role in Modulating the Small Intestinal Microbiota Composition as Compared to Diet

Microbiology Spectrum, 2023
The intestinal microbiota is at the interface between the host and its environment and thus under constant exposure to host-derived and external modulators.
Fabiola Puértolas-Balint, Bjoern O. Schroeder   +1 more
doaj   +1 more source

Increased expression and levels of human β defensins (hBD2 and hBD4) in adults with dental caries

Journal of Health Sciences, 2013
Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two ...
Girolamo Jose Barrera, Gabriela Sanchez Tortolero, Adriana Rivas, Carmen Flores, Jose Emanuele Gonzales   +4 more
doaj   +3 more sources

Antimicrobial peptides: agents of border protection for companion animals. [PDF]

, 2012
Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis.
Affolter, Verena K, Bevins, Charles L, Leonard, Brian C   +2 more
core   +1 more source

FUNCTIONAL EFFECTS OF θ-DEFENSINS FROM BLOOD LEUKOCYTES OF BABOON PAPIO HAMADRYAS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2018
Aim. Study the functional properties of cationic antimicrobial peptides 0-defensins isolated from baboon Papio hamadryas blood leukocytes. Materials and methods.
E. V. Tsvetkova, G. M. Aleshina, L. E. Leonovа, O. V. Shamova, E. V. Romanovskaya, V. N. Kokryakov   +5 more
doaj   +1 more source

Anti-tumor necrosis factor-alpha therapy during murine Klebsiella pneumoniae bacteremia: increased mortality in the absence of liver injury. [PDF]

, 2003
Klebsiella pneumoniae is a leading cause of gram-negative bacterial pneumonia, often resulting in bacteremia concurrent with the localized pulmonary infection.
Cogen, Anna L, Lau, Helen Y, Monteleon, Christine L, Moore, Thomas A, Standiford, Theodore J   +4 more
core   +1 more source

A genome-wide screen identifies a single β-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins

BMC Genomics, 2004
Background Defensins comprise a large family of cationic antimicrobial peptides that are characterized by the presence of a conserved cysteine-rich defensin motif.
Xiao Yanjing, Hughes Austin L, Ando Junko, Matsuda Yoichi, Cheng Jan-Fang, Skinner-Noble Donald, Zhang Guolong   +6 more
doaj   +1 more source

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. [PDF]

, 2016
Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed.
Cai, Linbi, Chen, Zishuo, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Lai, Yuchen, Liu, Zhenqui, Lugea, Aurelia, Luo, Mei, Nie, Yuanyang, Pandol, Stephen J, Su, Danmei, Sun, Qun, Tsukamoto, Hidekazu, Wu, Guihui, Wu, Pengfei, Xiao, Zhixiong, Zhang, Li, Zheng, Sujun, Zhu, Airu   +19 more
core   +2 more sources

Avian defensins

Veterinary Immunology and Immunopathology, 2008
Modulation of defensin expression may be one way to improve animal health and to reduce zoonotic diseases. Defensins are small, cationic, and amphipathic cysteine-rich antibiotic peptides found in plants, insects, mammals and birds. Whereas alpha- and theta-defensins appear to be absent in birds, several beta-defensins have been isolated from avian ...
van Dijk, A., Veldhuizen, E.J.A., Haagsman, H.P.   +2 more
openaire   +4 more sources