Results 41 to 50 of about 1,130 (180)
Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry
Viruses, 2021 Innate immunity during acute infection plays a critical role in the disease severity of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and is likely to contribute to COVID-19 disease outcomes.
Chuan Xu +10 more
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The Chemistry and Biology of Theta Defensins [PDF]
Angewandte Chemie International Edition, 2014 AbstractCyclic peptides are found in a diverse range of organisms and are characterized by their stability and role in defense. Why is only one class of cyclic peptides found in mammals? Possibly we have not looked hard enough for them, or the technologies needed to identify them are not fully developed.
Conibear, Anne C., Craik, David J.
openaire +5 more sources
Advanced Science, EarlyView.Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu +5 more
wiley +1 more source
Antifungal defensins and their role in plant defense
Frontiers in Microbiology, 2014 Since the beginning of the 90’s lots of cationic plant, cysteine-rich antimicrobial peptides (AMP) have been studied. However, Broekaert only coined the term plant defensin in 1995, after comparison of a new class of plant antifungal peptides with known
Ariane eLacerda +4 more
doaj +1 more source
Human β-defensin 4 – defensin without the “twist”
Postępy Biochemii, 2016 β-defensins are small, cysteine-rich, cationic peptides that contribute to various processes related to both arms of host defense, the innate and adaptive immunities. All β-defensins are potent antimicrobials with activity targeting a broad range of pathogens.
Adam, Prahl +3 more
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The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation
American Journal of Hematology, EarlyView.ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao +4 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Introduction Chronic rhinosinusitis (CRS) is an inflammatory disease with many different contributing factors, including bacterial infection. CRS patients are typically managed with medical therapies; however, these treatments frequently fail, leaving surgery as the only viable option.
Sintayehu Ambachew +8 more
wiley +1 more source
Modelling study of dimerization in mammalian defensins
BMC Bioinformatics, 2006 Background Defensins are antimicrobial peptides of innate immunity functioning by non-specific binding to anionic phospholipids in bacterial membranes.
Verma Chandra, Suresh Anita
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Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. [PDF]
PLoS ONE, 2010 Defensins are antimicrobial peptides expressed by plants and animals. In mammals there are three subfamilies of defensins, distinguished by structural features: alpha, beta and theta. Alpha and beta-defensins are linear peptides with broad anti-microbial
Aprille Seidel +8 more
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Peptides as toxins/defensins [PDF]
Amino Acids, 2010 Sao Paulo State Univ, UNESP, Inst Biosci Rio Claro, Dept Biol,Ctr Study Social Insects CEIS, BR-13506900 Rio Claro, SP ...
openaire +3 more sources