Results 41 to 50 of about 22,371 (222)
Defensin-driven viral evolution.
PLoS Pathogens, 2020 Enteric alpha-defensins are potent effectors of innate immunity that are abundantly expressed in the small intestine. Certain enteric bacteria and viruses are resistant to defensins and even appropriate them to enhance infection despite neutralization of
Karina Diaz +7 more
doaj +1 more source
SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells
Animal Models and Experimental Medicine, EarlyView.The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang +6 more
wiley +1 more source
Animals, 2023 β-Defensins are cationic antimicrobial peptides (AMPs) that play an important role in the innate immune defense of bovines. They are constitutively expressed in mammary glands and induced differently in response to pathogens.
Mojtaba Daneshi +4 more
doaj +1 more source
Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry
Viruses, 2021 Innate immunity during acute infection plays a critical role in the disease severity of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and is likely to contribute to COVID-19 disease outcomes.
Chuan Xu +10 more
doaj +1 more source
Human β-defensin 4 – defensin without the “twist”
Postępy Biochemii, 2016 β-defensins are small, cysteine-rich, cationic peptides that contribute to various processes related to both arms of host defense, the innate and adaptive immunities. All β-defensins are potent antimicrobials with activity targeting a broad range of pathogens.
Adam, Prahl +3 more
openaire +3 more sources
Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions [PDF]
Journal of Virology, 2016 ABSTRACT Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro . The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus ...
Sarah S. Wilson +3 more
openaire +2 more sources
Animal Research and One Health, EarlyView.We conducted a longitudinal trial across nursery, growing, and finishing phases, showing that phytochemical supplementation as a potential antibiotic alternative reduced potential pathogens and promoted beneficial Lactobacillus amylovorus in the nursery phase, and enriched amino acid and carbohydrate metabolism pathways (prediction) during finishing ...
Ziyu Liu +11 more
wiley +1 more source
Modelling study of dimerization in mammalian defensins
BMC Bioinformatics, 2006 Background Defensins are antimicrobial peptides of innate immunity functioning by non-specific binding to anionic phospholipids in bacterial membranes.
Verma Chandra, Suresh Anita
doaj +1 more source
The Chemistry and Biology of Theta Defensins [PDF]
Angewandte Chemie International Edition, 2014 AbstractCyclic peptides are found in a diverse range of organisms and are characterized by their stability and role in defense. Why is only one class of cyclic peptides found in mammals? Possibly we have not looked hard enough for them, or the technologies needed to identify them are not fully developed.
Conibear, Anne C., Craik, David J.
openaire +5 more sources
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source