Results 61 to 70 of about 1,130 (180)

Synovial interleukin‐6 point‐of‐care testing, alone and combined with D‐dimer, supports rapid diagnosis of periprosthetic joint infection

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Data on the reliability of point‐of‐care (POC) tests for the rapid diagnosis of periprosthetic joint infections (PJI) using synovial fluid (SF) D‐dimer (DD), interleukin 6 (IL‐6) and procalcitonin (PCT) are limited. This study aimed to address this issue by evaluating the diagnostic accuracy of POC tests for SF DD, IL‐6 and PCT in ...
Sujeesh Sebastian, Hibah Abdulwahab Abusulaiman, Veronika Achatz, Matteo Spadini, Tobias Josef Niedrist, Markus Herrmann, Jochen Gerhard Hofstaetter   +6 more
wiley   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

Defensins: The Case for Their Use against Mycobacterial Infections

Journal of Immunology Research, 2016
Human tuberculosis remains a huge global public health problem with an estimated 1/3rd of the population being infected. Defensins are antibacterial cationic peptides produced by a number of cell types, most notably neutrophil granulocytes and epithelial
Haodi Dong, Yue Lv, Deming Zhao, Paul Barrow, Xiangmei Zhou   +4 more
doaj   +1 more source

The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets

mBio, 2019
Big defensins, ancestors of β-defensins, are composed of a β-defensin-like C-terminal domain and a globular hydrophobic ancestral N-terminal domain.
Karine Loth, Agnès Vergnes, Cairé Barreto, Sébastien N. Voisin, Hervé Meudal, Jennifer Da Silva, Albert Bressan, Nawal Belmadi, Evelyne Bachère, Vincent Aucagne, Chantal Cazevielle, Hélène Marchandin, Rafael Diego Rosa, Philippe Bulet, Lhousseine Touqui, Agnès F. Delmas, Delphine Destoumieux-Garzón   +16 more
doaj   +1 more source

The Airway Epithelial Barrier in Childhood Asthma: A Central Player in Glucocorticoid Therapy, Resistance, and Severe Asthma

Pediatric Discovery, EarlyView.
ABSTRACT Childhood asthma remains a global public health challenge with suboptimal control, despite the availability of inhaled corticosteroids (ICS) as first‐line therapy. Glucocorticoids suppress inflammation and protect the airway epithelial barrier (AEB) via genomic and nongenomic pathways.
Tangqiaochu Gan, Zhou Fu, Chao Niu
wiley   +1 more source

Cationic Antimicrobial Peptides of Respiratory Tract Nonspecific Defense System: Defensins and Cathelicidins. Defensins — Molecules Undergoing a Renaissance (Part 4)

Zdorovʹe Rebenka, 2012
This review presents the main systemic actions of defensins. Special attention is paid to modulatory effects of defensins on the processes of inflammation and immune response.
A.Ye. Abaturov
doaj   +1 more source

Emerging Agents for Boron Neutron Capture Therapy: Biomolecular Carriers Paving the Way for Precision Radiotherapy

Precision Radiation Oncology, EarlyView.
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen, Maosong Yang, Jiheng Wang, Ling Zhang, Shaobo Huang, Xiao Xu, Yang Liu   +6 more
wiley   +1 more source

Exploring the therapeutic potential of recombinant bovine β-defensins for antimicrobial and anti-inflammatory functions in sepsis management

Veterinary Research
β-defensins are multifunctional peptides of the host immune system involved in responses to infectious diseases. We investigated the potential of five recombinant proteins based on bovine β-defensins (bovine neutrophil β-defensins (BNBD) 1, 2, 3, and 4 ...
Cristina Saubi, Ricardo Baltà-Foix, Jose Vicente Carratalá, Francesc Fàbregas, Daniel Sandín, Marc Torrent, Elena Garcia-Fruitós, Anna Arís   +7 more
doaj   +1 more source

Defensins: antifungal lessons from eukaryotes

Frontiers in Microbiology, 2014
Over the last years, antimicrobial peptides (AMPs) have been the focus of intense research towards the finding of a viable alternative to current antifungal drugs.
Patrícia M. Silva, Sónia eGonçalves, Nuno C. Santos   +2 more
doaj   +1 more source

Improving the Digestibility of Plant Defensins to Meet Regulatory Requirements for Transgene Products in Crop Protection

Frontiers in Plant Science, 2020
Despite the use of chemical fungicides, fungal diseases have a major impact on the yield and quality of plant produce globally and hence there is a need for new approaches for disease control.
Kathy Parisi, Simon Poon, Rosemary F. Renda, Gurinder Sahota, James English, James English, Nasser Yalpani, Nasser Yalpani, Mark R. Bleackley, Marilyn A. Anderson, Nicole L. van der Weerden   +10 more
doaj   +1 more source