Results 71 to 80 of about 28,067 (241)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

High level expression of human epithelial β-defensins (hBD-1, 2 and 3) in papillomavirus induced lesions

Virology Journal, 2006
Background Epithelial defensins including human β-defensins (hBDs) and α-defensins (HDs) are antimicrobial peptides that play important roles in the mucosal defense system.
Chong Kong T, Xiang Liangbin, Wang Xiaohong, Jun Eunjoo L, Xi Long-fu, Schweinfurth John M   +5 more
doaj   +1 more source

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

VIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu, Lei Meng, Wenzhu Song, Peiyu Wang, Bin Liu, Shihui Liu, Qi He, Bing Sun, Wanheng Li, Zhiwei Guan, Rui Dong, Qiang Feng   +11 more
wiley   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Research progress on biological function of mammalian defensins

Siliao yanjiu, 2023
Mammalian defensin is a kind of cationic polypeptide. It can be divided into α-defensin, β-defensin, and θ-defensin according to structural differences.
ZHAO Feng, CUI Hai-ting, ZHOU Yu-qi, HAN Peng   +3 more
doaj  

The Effects of Noise on the Juvenile Life Stage of Crustaceans: Behavioral, Cellular, and Molecular Responses in Procambarus clarkii

Integrative Zoology, EarlyView.
Juvenile Procambarus clarkii exposed to noise exhibited behavioral changes, shifts in enzymatic activity, and altered expression of stress and immune genes. The findings highlight the sensitivity of invertebrate juveniles to anthropogenic acoustic pollution.
Maria Ceraulo, Giuseppa Buscaino, Clarissa De Vita, Aiti Vizzini, Mirella Vazzana, Elena Papale, Francesco Longo, Francesco Paolo Faraone, Manuela Mauro   +8 more
wiley   +1 more source

The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets

mBio, 2019
Big defensins, ancestors of β-defensins, are composed of a β-defensin-like C-terminal domain and a globular hydrophobic ancestral N-terminal domain.
Karine Loth, Agnès Vergnes, Cairé Barreto, Sébastien N. Voisin, Hervé Meudal, Jennifer Da Silva, Albert Bressan, Nawal Belmadi, Evelyne Bachère, Vincent Aucagne, Chantal Cazevielle, Hélène Marchandin, Rafael Diego Rosa, Philippe Bulet, Lhousseine Touqui, Agnès F. Delmas, Delphine Destoumieux-Garzón   +16 more
doaj   +1 more source

A molecular dynamics study of human defensins HBD-1 and HNP-3 in water

, 2010
Mammalian defensins are crucial components of the innate immune system. They are characterized by three disulfide bridges and exhibit broad spectrum antibacterial activity. The spacing between the cysteines and disulfide connectivities in the two classes
Ambure, Sharadadevi, Ramakrishnan, Nagaraj   +1 more
core  

Heatwave‐Resilient Cuticular Microbiota Protect the Leaf Beetle Plagiodera versicolora From Fungal Infection

Integrative Zoology, EarlyView.
ABSTRACT The increasing frequency and intensity of heatwaves—extreme thermal events characterized by prolonged supra‐optimal temperatures—exert profound impacts on global ecosystem stability and species interactions. While the disruptive effects of thermal stress on host physiology and gut microbiota are well documented, the role of cuticular ...
Jiyu Wu, Chengjie Tu, Rongshan Fan, Letian Xu   +3 more
wiley   +1 more source