Results 91 to 100 of about 28,067 (241)

Tribolium castaneum defensins are primarily active against Gram-positive bacteria

, 2022
S.208-215The red flour beetle Tribolium castaneum is a destructive insect pest of stored food and feed products, and a model organism for development, evolutionary biology and immunity.
Vilcinskas, A., Cabezas-Cruz, A., Valdés, J.J., Knorr, E., Tonk, M., Kollewe, C.   +5 more
core   +1 more source

Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen

Reproductive Biology and Endocrinology, 2011
Background During pregnancy the immune system of the mother must protect any activation that may negatively affect the fetus. Changes in susceptibility to infection as well as resolution of some autoimmune disorders represent empirical evidence for ...
Sperling Rhoda, Rodríguez-García Marta, Escribese Maria M, Engel Stephanie M, Gallart Teresa, Moran Thomas M   +5 more
doaj   +1 more source

RNA activation in insects: From emerging evidence to molecular applications

Insect Molecular Biology, EarlyView.
Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley   +1 more source

Revealing the Properties of Plant Defensins through Dynamics

Molecules, 2013
Defensins are potent, ancient natural antibiotics that are present in organisms ranging from lower organisms to humans. Although the structures of several defensins have been well characterized, the dynamics of only a few have been studied.
Fabio C. L. Almeida, Viviane Silva de Paula, Ana Paula Valente   +2 more
doaj   +1 more source

Human defensins and LL-37 in mucosal immunity

, 2009
Defensins are widespread in nature and have activity against a broad range of pathogens. Defensins have direct antimicrobial effects and also modulate innate and adaptive immune responses.
Kevan L. Hartshorn, Mona Doss, Mitchell R. White, Tesfaldet Tecle   +3 more
core   +1 more source

Fecal α-defensins in GVHD [PDF]

, 2015
Background: Intestinal microbial ecology is actively regulated by Paneth cell-derived antimicrobial peptides, α-defensins. Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (SCT). We previously
Nakamura, K., Eriguchi, Y., K. Nakamura, D. Hashimoto, T. Teshima, Akashi, K., Shimono, N., Y. Eriguchi, T. Ayabe, Shimoda, S., Ayabe, T., Teshima, T., Hashimoto, D., S. Shimoda, K. Akashi, N. Shimono   +15 more
core   +1 more source

STAG Priming Preserves Paneth Cells and Limits Parasite‐Triggered Ileitis

Immunology &Cell Biology, EarlyView.
Preservation of Paneth cells is associated with resistance to ileitis caused by Toxoplasma gondii. ABSTRACT Toxoplasma gondii triggered ileitis is a commonly used model for diseases affecting the small intestine, such as Crohn's Disease. Inflammation is primarily dependent on Th1‐mediated killing of Paneth cells, which consequently promotes intestinal ...
Ester Cristina Borges Araujo, Luciana Alves Sousa, Marisol Pallete Briceno, Loyane Bertagnolli Coutinho, Alexsandra Alves Bezerra Martins, Anne Fenton, Sumathi Sankaran‐Walters, Paulo Czarnewski, Neide Maria Silva   +8 more
wiley   +1 more source

Milk‐Derived Signals Guide Neonatal Hematopoiesis and Respiratory Defense

Immunology &Cell Biology, EarlyView.
This commentary summarises a recent paper in Cell by Howard et al. showing that osteopontin shapes the infant microbiome, which in turn directs early immune development in the airways. This early programming confers protection against respiratory tract infections that persists well beyond infancy.
Jonatan Leffler, Nivedithaa Divakara, Valerie Verhasselt   +2 more
wiley   +1 more source

Multi‐omics analyses reveal host–microbe interactions in atopic dermatitis and psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Atopic dermatitis (AD) and psoriasis (PSO) are chronic inflammatory skin diseases with complex host–microbe interactions. This study analysed skin samples from patients and healthy individuals using integrated microbial and transcriptomic profiling. Both diseases showed disrupted fungal–bacterial interactions and alterations in host immune responses ...
Ying Yang, Peter Olah, Alexander Salava, Jonathan Barker, Antti Lauerma, Björn Andersson, Nanna Fyhrquist, Bernhard Homey, Harri Alenius   +8 more
wiley   +1 more source

Repurposing of human defensins as a promising antiviral therapeutics against SARS-CoV-2

The Microbe
Human defensins are also known to have promising antiviral activities against both enveloped and non-enveloped viruses. The world has already faced panic during the COVID-19 pandemic and alarms us to get ready to fight the emergence of new highly mutated
Roy Dinata, Monika Vashisht, Santi M. Mandal, Piyush Baindara   +3 more
doaj   +1 more source