Mechanisms of AAV neutralization by human alpha-defensins [PDF]
PLoS PathogensAntiviral immunity compromises the efficacy of adeno-associated virus (AAV) vectors used for gene therapy. This is well understood for the adaptive immune response.
Jessica M Porter +2 more
exaly +6 more sources
Enteric alpha defensins in norm and pathology [PDF]
Annals of Clinical Microbiology and Antimicrobials, 2012 Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in ...
George S Krasnov +2 more
exaly +7 more sources
Evaluation of alpha-defensins as a marker of severity in chronic obstructive pulmonary disease [PDF]
Lung IndiaBackground Defensins are key effector molecules of innate immunity that can contribute towards the diagnosis and monitoring of chronic obstructive pulmonary disease (COPD).
Shivani Jaswal, Varinder Saini
exaly +6 more sources
Alpha‐defensins: risk factor for thrombosis in COVID‐19 infection [PDF]
British Journal of Haematology, 2021 SummaryThe inflammatory response to SARS/CoV‐2 (COVID‐19) infection may contribute to the risk of thromboembolic complications. α‐Defensins, antimicrobial peptides released from activated neutrophils, are anti‐fibrinolytic and prothrombotic in vitro and in mouse models.
Suhair Abdeen +2 more
exaly +5 more sources
Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency [PDF]
Frontiers in ImmunologyNeutrophilic inflammation and a high level of free α-defensins are main features of chronic airway inflammation in alpha-1 antitrypsin-deficient (AATD) individuals.
Jungnam Lee +2 more
exaly +4 more sources
Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen [PDF]
Reproductive Biology and Endocrinology, 2011 Background During pregnancy the immune system of the mother must protect any activation that may negatively affect the fetus. Changes in susceptibility to infection as well as resolution of some autoimmune disorders represent empirical evidence for ...
Sperling Rhoda +5 more
doaj +6 more sources
Alpha-defensins inhibit ERK/STAT3 signaling during monocyte-macrophage differentiation and impede macrophage function [PDF]
Respiratory Research, 2023 Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder associated with a 5–tenfold decrease in lung levels of alpha-1-antitrypsin (AAT) and an increased risk for obstructive lung disease.
Jungnam Lee +5 more
doaj +2 more sources
Antimicrobial Peptides and Systemic Inflammation: A Network Analysis [PDF]
Immunity, Inflammation and DiseaseIntroduction Antimicrobial peptides (AMPs) are essential components of the innate immune system, exhibiting diverse mechanisms of action. Objective This study investigates the roles of cathelicidin (LL‐37), alpha‐defensins, and the S100 proteins S100A8 ...
Fabiano Pinheiro da Silva +2 more
doaj +2 more sources
Exploring the therapeutic potential of recombinant bovine β-defensins for antimicrobial and anti-inflammatory functions in sepsis management [PDF]
Veterinary Researchβ-defensins are multifunctional peptides of the host immune system involved in responses to infectious diseases. We investigated the potential of five recombinant proteins based on bovine β-defensins (bovine neutrophil β-defensins (BNBD) 1, 2, 3, and 4 ...
Cristina Saubi +7 more
doaj +2 more sources
Inflammatory burden in dialysis patients: the role of alpha defensin. [PDF]
Front ImmunolIntroduction The major neutrophilic peptide alpha-defensin plays a pivotal role in atherogenesis. Atherosclerosis is more frequent in dialysis patients, increasingly ascribed to chronic low-grade inflammation.
Shapira M +5 more
europepmc +3 more sources