Antimicrobial proteins and peptides in pregnancy: Guardians of the maternal–fetal frontier [PDF]
Frontiers in ImmunologyThe success of human pregnancy relies on the precise synchronization and adaptation of the maternal immune system, which, together with fetal tissues, establishes a tolerogenic intrauterine environment while maintaining the capacity to mount effective ...
Andrea Olmos-Ortiz +6 more
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Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Matthew Brook +2 more
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Determination of alpha-defensin levels in dynamics in newborns with sepsis
Сучасна педіатрія: УкраїнаAim - to investigate some pathogenetic mechanisms of immune system changes during sepsis in premature and full-term infants by determining the levels of alpha-defensin. Materials and methods. A total of 130 newborns were examined.
N.T. Kerimova
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Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy [PDF]
Journal of Virology, 2017 Sucheol Gil +2 more
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Delineation of Interfaces on Human Alpha-Defensins Critical for Human Adenovirus and Human Papillomavirus Inhibition [PDF]
PLoS Pathogens, 2014 Victoria R Tenge +2 more
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Human Neutrophil Alpha-Defensins Promote NETosis and Liver Injury in Alcohol-Related Liver Cirrhosis: Potential Therapeutic Agents [PDF]
Journal of Clinical MedicineAnna Rycyk +2 more
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False-negative synovial alpha-defensin [PDF]
Arthroplasty Today, 2017 We present a case of chronic periprosthetic hip infection diagnosed using the Musculoskeletal Infection Society criteria as the gold standard. The alpha-defensin test was falsely negative. The diagnostic workup of the patient is detailed, along with a discussion regarding the potential reasons behind the misleading alpha-defensin results.
Jake R. Adams, MD, Adam J. Schwartz, MD
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Alpha-Defensin 1: An Emerging Periodontitis Biomarker
Diagnostics, 2023 Background: Research on the development of reliable diagnostic targets is being conducted to overcome the high prevalence and difficulty in managing periodontitis. However, despite the development of various periodontitis target markers, their practical application has been limited due to poor diagnostic accuracy.
Jisuk Lee +3 more
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Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. [PDF]
PLoS ONE, 2010 Defensins are antimicrobial peptides expressed by plants and animals. In mammals there are three subfamilies of defensins, distinguished by structural features: alpha, beta and theta. Alpha and beta-defensins are linear peptides with broad anti-microbial
Aprille Seidel +8 more
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International Journal of Infectious Diseases, 2023 Objectives: Nosocomial ventriculitis is a difficult infectious condition to diagnose given that typical cerebral spinal fluid (CSF) parameters, commonly used in the diagnosis of meningitis, lack sensitivity and specificity in nosocomial ventriculitis ...
James B. Doub
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