Results 31 to 40 of about 9,164 (193)
Alpha Defensin: A Diagnostic Accuracy Depending on the Infection Definition Used
The Journal of Arthroplasty, 2020 The purpose of this study was to evaluate the alpha defensin qualitative detection (ADLF) sensitivity and specificity as compared with 3 standard classifications in the diagnostic management of chronic prosthetic joint infections.A multicenter cohort of 136 patients with a painful arthroplasty was classified into either infected or noninfected ...
Huard, Maxime +8 more
openaire +3 more sources
Comparative Genomics and Evolution of the Alpha-Defensin Multigene Family in Primates [PDF]
Molecular Biology and Evolution, 2010 Defensin genes encode small cationic antimicrobial peptides that form an important part of the innate immune system. They are divided into three families, alpha (α), beta (β), and theta (), according to arrangement of the disulfide bonding pattern between cysteine residues.
Sabyasachi, Das +6 more
openaire +2 more sources
Human defensins and Th-1 cytokines in hepatitis C viral infection
The Pan African Medical Journal, 2020 INTRODUCTION: Active or chronic exacerbated forms of hepatitis C virus (HCV) infection subsequently progress to liver disease and human defensins has been determined to have some level of anti-viral properties invitro whilst the expression of T helper-1 ...
Dorcas Ohui Owusu +2 more
doaj +1 more source
Comparative analysis of the stability features of human alpha-defensins as candidates for the future COVID-19 therapy through molecular dynamics [PDF]
Pharmaciana, 2022 Coronavirus 19 (COVID-19) is still a global health issue to date, SARS-CoV-2 is a novel coronavirus that is responsible for this sickness. The receptor-binding domain of the SARS-CoV-2 virus associates with angiotensin-converting enzyme 2 (ACE-2) and ...
Taufik Muhammad Fakih +2 more
doaj +1 more source
Alpha Defensins 1, 2, and 3 [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 Objectives— α-Defensins are natural antibiotics made by neutrophils that have been reported to modulate cholesterol metabolism and vascular function; however, their role in vivo remains largely unknown.
Abel, López-Bermejo +8 more
openaire +2 more sources
Alpha-defensin-dependent enhancement of enteric viral infection
PLOS Pathogens, 2017 The small intestinal epithelium produces numerous antimicrobial peptides and proteins, including abundant enteric α-defensins. Although they most commonly function as potent antivirals in cell culture, enteric α-defensins have also been shown to enhance some viral infections in vitro. Efforts to determine the physiologic relevance of enhanced infection
Sarah S. Wilson +6 more
openaire +4 more sources
Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome
BMC Genomics, 2009 Background Host defense peptides are a critical component of the innate immune system. Human alpha- and beta-defensin genes are subject to copy number variation (CNV) and historically the organization of mouse alpha-defensin genes has been poorly defined.
Dougan Gordon +6 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
PLoS Pathogens, 2022 During infection, Bacillus anthracis bacilli encounter potent antimicrobial peptides (AMPs) such as defensins. We examined the role that B. anthracis capsule plays in protecting bacilli from defensins and other cationic AMPs by comparing their effects on
David K O'Brien +7 more
doaj +1 more source
Reawakening retrocyclins: ancestral human defensins active against HIV-1.
PLoS Biology, 2009 Human alpha and beta defensins contribute substantially to innate immune defenses against microbial and viral infections. Certain nonhuman primates also produce theta-defensins-18 residue cyclic peptides that act as HIV-1 entry inhibitors. Multiple human
Nitya Venkataraman +7 more
doaj +1 more source