Results 41 to 50 of about 9,164 (193)

Determinants of Mouse Alpha‐Defensin Bactericidal Activity

The FASEB Journal, 2006
Mouse Paneth cell cryptdins are expressed as inactive propeptides and are activated upon proteolysis by MMP‐7. MMP‐7 cleavage sites Ser 43 ↓ Ile 44 , Ala 53 ↓ Leu 54 , and ...
Colby Sanford Weeks, Hiroki Tanabe, Steve P. Crampton, Melanie J. Cocco, Andre J. Ouellette   +4 more
openaire   +1 more source

Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study

Respiratory Research, 2006
Background Alpha-defensins, which are major constituents of neutrophil azurophilic granules, and beta-defensins, which are expressed in airway epithelial cells, could contribute to the pathogenesis of chronic obstructive pulmonary disease by amplifying ...
Anthonisen Nicholas R, Connett John E, Ruan Jian, Burkett Kelly M, He Jian-Qing, Wallace Alison M, Paré Peter D, Sandford Andrew J   +7 more
doaj   +1 more source

Expression of human beta-defensins in children with chronic inflammatory bowel disease. [PDF]

PLoS ONE, 2010
BACKGROUND: Human beta-defensins (hBDs) are antimicrobial peptides known to play a major role in intestinal innate host defence. Altered mucosal expression of hBDs has been suggested to be implicated in chronic inflammatory bowel disease pathogenesis ...
Matthias Zilbauer, Andreas Jenke, Gundula Wenzel, Jan Postberg, Andreas Heusch, Alan D Phillips, Gabriele Noble-Jamieson, Franco Torrente, Camilla Salvestrini, Robert Heuschkel, Stefan Wirth   +10 more
doaj   +1 more source

Diagnostic and prognostic significance of alpha-defensin in patients with chronic heart failure during 2-year follow-up

Journal of Education, Health and Sport, 2018
Background Defensins play an important role in the processes associated with innate immunity. Their growth is observed in sites of intense inflammation, but also in less severe inflammation.
Joanna Banach, Łukasz Wołowiec, Daniel Rogowicz, Wojciech Gilewski, Katarzyna Buszko, Danuta Karasek, Piotr Małyszka, Walery Zukow, Władysław Sinkiewicz   +8 more
doaj   +3 more sources

Histidine-Rich Defensins from the Solanaceae and Brasicaceae Are Antifungal and Metal Binding Proteins

Journal of Fungi, 2020
Plant defensins are best known for their antifungal activity and contribution to the plant immune system. The defining feature of plant defensins is their three-dimensional structure known as the cysteine stabilized alpha-beta motif. This protein fold is
Mark R. Bleackley, Shaily Vasa, Peta J. Harvey, Thomas M. A. Shafee, Bomai K. Kerenga, Tatiana P. Soares da Costa, David J. Craik, Rohan G. T. Lowe, Marilyn A. Anderson   +8 more
doaj   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Theta-Defensins Inhibit High-Risk Human Papillomavirus Infection Through Charge-Driven Capsid Clustering

Frontiers in Immunology, 2020
Persistent infection with high-risk human papillomavirus (hrHPV) genotypes results in a large number of anogenital and head and neck cancers worldwide. Although prophylactic vaccination coverage has improved, there remains a need to develop methods that ...
Joseph G. Skeate, Wouter H. Segerink, Mauricio D. Garcia, Daniel J. Fernandez, Ruben Prins, Kim P. Lühen, Féline O. Voss, Diane M. Da Silva, Diane M. Da Silva, W. Martin Kast, W. Martin Kast, W. Martin Kast   +11 more
doaj   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Vitamin D Signaling Through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

Frontiers in Physiology, 2016
Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD)，is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed ...
Danmei Su, Airu Zhu, Yuanyang Nie, Zishuo Chen, Pengfei Wu, Li Zhang, Mei Luo, Qun Sun, Linbi Cai, Yuchen Lai, Zhixiong Xiao, Zhongping Duan, Sujun Zheng, Guihui Wu, Richard Hu, Hidekazu Tsukamoto, Aurelia Lugea, Stephen J Pandol, Yuan-Ping Han, Yuan-Ping Han   +19 more
doaj   +1 more source

Accurate measurement of gene copy number for human alpha-defensin DEFA1A3 [PDF]

BMC Genomics, 2013
Abstract Background Multi-allelic copy number variants include examples of extensive variation between individuals in the copy number of important genes, most notably genes involved in immune function. The definition of this variation, and analysis of its impact on function, has been hampered by the technical ...
Khan, Fayeza F., Carpenter, Danielle, Mitchell, Laura, Mansouri, Omniah, Black, Holly A., Tyson, Jess, Armour, John A.L.   +6 more
openaire   +3 more sources