Results 101 to 110 of about 28,067 (241)
Defensins identified through molecular de-extinction
International audienceMolecular de-extinction is an emerging field that identifies potentially useful molecules throughout evolution. Here, we computationally mine genomes, searching for molecules called defensins, which play a role in host immunity. Our
Macedo, Maria L.R. +9 more
core +1 more source
Expression of defensins in non-infected araneomorph spiders [PDF]
, 2018 Defensins are a major family of antimicrobial peptides found throughout the phylogenetic tree. From the spider species: Cupiennius salei, Phoneutria reidyi, Polybetes pythagoricus, Tegenaria atrica, and Meta menardi, defensins belonging to the ‘ancestral'
Largiadèr, Carlo +3 more
core
Computational study on Polydatin with the Human Alpha-Defensins and the Human Beta Defensins evaluated by Blind Molecular Docking method [PDF]
, 2023 In a comprehensive Molecular Docking investigation using Autodock Vina with the Pyrx program, six Human Defensins (Alpha Defensin-1, Alpha Defensin-3, Alpha Defensin-4, Beta-Defensin-1, Beta-Defensin-2, Beta Defensin-3) were studied alongside various ...
Ravagnan, Giampietro, Ferrari, Ivan Vito
core
Pathogenesis of hidradenitis suppurativa: From susceptibility to chronicity
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review describes hidradenitis suppurativa as a heterogeneous disorder in which genetic susceptibility, epithelial dysfunction, environmental exposures, immune activation and microbial ecology converge differently across patients and disease stages.
Kelsey R. van Straalen +5 more
wiley +1 more source
Antibiotics, 2014 θ-Defensins are cyclic antimicrobial peptides expressed in leukocytes of Old world monkeys. To get insight into their antibacterial mode of action, we studied the activity of RTDs (rhesus macaque θ-defensins) against staphylococci.
Miriam Wilmes +9 more
doaj +1 more source
Sequence motifs and electrostatic features of primate cyclic θ-defensins.
, 2014 A: The θ-defensin octadecapeptide is formed by the head-to-tail ligation of two nonapeptides. The sequence logo for the nonapeptide is generated using all the primate θ-defensins. Sites 3I and 5R are under positive selection and are marked with asterisks.
Jing-Fei Huang (166496) +2 more
core +1 more source
Hidradenitis suppurativa skin microbiome: In‐depth analysis and modulation by systemic therapies
Journal of the European Academy of Dermatology and Venereology, EarlyView.Hidradenitis suppurativa skin exhibits profound dysbiosis, characterized by the depletion of homeostatic commensals and expansion of anaerobic pathogens. Longitudinal evaluation reveals that while systemic antibiotics successfully reverse HS dysbiosis, biologics (adalimumab and secukinumab) fail to clear pathogens despite clinical healing.
Yacine Amar +8 more
wiley +1 more source
Reawakening retrocyclins: ancestral human defensins active against HIV-1.
PLoS Biology, 2009 Human alpha and beta defensins contribute substantially to innate immune defenses against microbial and viral infections. Certain nonhuman primates also produce theta-defensins-18 residue cyclic peptides that act as HIV-1 entry inhibitors. Multiple human
Nitya Venkataraman +7 more
doaj +1 more source
Defensins in Viral Infection and Pathogenesis
, 2017 α, β, and θ defensins are effectors of the innate immune system with potent antibacterial, antiviral, and antifungal activity. Defensins have direct antiviral activity in cell culture, with varied mechanisms for individual viruses, although some common ...
Mayumi K. Holly +2 more
core +1 more source
theta-Defensins: Cyclic Peptides with Endless Potential [PDF]
, 2012 theta-Defensins, the only cyclic peptides of animal origin, have been isolated from the leukocytes of rhesus macaques and baboons. Their biogenesis is unusual because each peptide is an 18-residue chimera formed by the head-to-tail splicing of ...
Selsted, Michael E. +2 more
core +1 more source