Results 121 to 130 of about 1,130 (180)

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections

open access: yesClinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali   +3 more
wiley   +1 more source

The Effect of Myrtacine and Celastrol‐Enriched Extract on Cutibacterium acnes Extracellular Vesicles

open access: yesInternational Journal of Dermatology, Volume 65, Issue 6, Page 1215-1224, June 2026.
Myrtacine alone, Celastrol‐enriched extract alone, or the combination of both ingredients were added to the culture medium either before (preventive condition) or after (modulating condition) incubation with C. acnes IA1 extracellular vesicles (EVs) from healthy and acne skin in immortalized keratinocytes (HaCaT cells) and human skin explants.
Caroline T. Cheung   +7 more
wiley   +1 more source

Immune endotypes in tuberculosis: Keys to decoding disease complexity

open access: yesJournal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor   +4 more
wiley   +1 more source

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

open access: yesMolecular Microbiology, Volume 125, Issue 6, Page 506-545, June 2026.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang   +12 more
wiley   +1 more source

Cyclophilin A‐mediated cis/trans isomerization modulates RIN4 to control intracellular rhizobial infection in legumes

open access: yesNew Phytologist, Volume 250, Issue 6, Page 3932-3945, June 2026.
Summary In most legume‐rhizobium symbioses, rhizobial colonization occurs through host‐derived intracellular infection threads, which enable rhizobial recruitment while presumably modulating the host immune system to prevent rejection. To investigate post‐translational regulation of immune responses during rhizobial infection, we focused on Cyclophilin
Takashi Goto   +8 more
wiley   +1 more source

The abundance of pollen coat small signaling proteins shows limited convergence between independent selfing transitions in Arabidopsis and Capsella

open access: yesNew Phytologist, Volume 250, Issue 5, Page 3460-3474, June 2026.
Summary In plants, a key example of convergence is the repeated evolution of floral traits associated with the transition from outcrossing to self‐fertilization, often resulting in the ‘selfing syndrome’ (e.g. reduced flower size and loss of scent). However, potentially overlooked changes concern the pollen coat, which plays a role in different aspects
Ömer İltaş   +7 more
wiley   +1 more source

Psyllid Cysteine Cathepsins Directly Cleave the Outer Membrane Protein BamD of Citrus Huanglongbing Pathogen

open access: yesPlant Biotechnology Journal, Volume 24, Issue 6, Page 3989-4004, June 2026.
ABSTRACT Candidatus Liberibacter asiaticus (CLas), the causative agent of citrus Huanglongbing (HLB), is transmitted by Asian citrus psyllid, Diaphorina citri; however, the role of the insect's immune effectors in defending against CLas remains poorly understood. This study reveals that D.
Yu Du   +9 more
wiley   +1 more source

Plant Peptides on the Rise: From Historical Insight to Future Applications

open access: yesPlant Biotechnology Journal, Volume 24, Issue 6, Page 3777-3802, June 2026.
ABSTRACT Plant peptides constitute a rapidly expanding class of signalling molecules essential to plant physiology, mediating key processes such as development, stress adaptation, and immune responses. This review traces the history of plant peptide research, from the seminal discovery of systemin to the recent identification of non‐canonical peptides (
Shunxi Wang   +5 more
wiley   +1 more source

Evaluation of the Cutaneous Immunological Milieu Before and After Treatment With Meglumine Antimoniate in Dogs Naturally Affected by Leishmaniosis due to Leishmania infantum

open access: yesVeterinary Dermatology, Volume 37, Issue 3, Page 455-463, June 2026.
Background: Canine leishmaniosis (CanL) is a zoonotic disease of variable severity. The typical immune response is driven by an exaggerated humoral immune response. Protective immunity is mediated by pro‐inflammatory cytokines that enhance macrophage leishmanicidal activity. Objective: To evaluate the cutaneous and the systemic immune responses as well
M. Platenik   +5 more
wiley   +1 more source

Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases

open access: yesThe FASEB Journal, Volume 40, Issue 10, 31 May 2026.
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda   +5 more
wiley   +1 more source

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