Results 141 to 150 of about 1,130 (180)
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Current Opinion in Hematology, 2014
Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms of action, and therapeutic potential continue to be
Le, Zhao, Wuyuan, Lu
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Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms of action, and therapeutic potential continue to be
Le, Zhao, Wuyuan, Lu
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Cell and Tissue Research, 2010
The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in ...
Linda, Hazlett, Minhao, Wu
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The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in ...
Linda, Hazlett, Minhao, Wu
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2013
The term defensin relates to a set of host defense peptides (HDPs)in vertebrates, invertebrates, plants, and molds that display structural similarities based on a cystine stabilized antiparallel bet-sheetcore, with an alpha-helical stretch also present in some membrers, Defensins of different origins exhibit structural and functional similarities, with
ANTCHEVA, Nikolinka +2 more
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The term defensin relates to a set of host defense peptides (HDPs)in vertebrates, invertebrates, plants, and molds that display structural similarities based on a cystine stabilized antiparallel bet-sheetcore, with an alpha-helical stretch also present in some membrers, Defensins of different origins exhibit structural and functional similarities, with
ANTCHEVA, Nikolinka +2 more
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Functional synergism of Human Defensin 5 and Human Defensin 6
Biochemical and Biophysical Research Communications, 2015The gut epithelium is critically involved in maintaining intestinal immune homeostasis. Acting as a physical barrier, it separates the intestinal microflora from cells of the immune system. In addition to its barrier function, the intestinal epithelium expresses defensins, natural, endogenous antimicrobial peptides.
Aiping, Zhao, Wuyuan, Lu, Erik, de Leeuw
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Techniques for Plant Defensin Production
Current Protein & Peptide Science, 2010To defend themselves from attack by pathogens, plants can rely only on their innate defense systems. Defensins are antimicrobial peptides that contribute to plant immunity by displaying a direct cidal activity against various pathogens, some of which are responsible for plant diseases. These determine a significant decrease in the quality and safety of
PADOVAN, LARA +3 more
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Science, 1999
Defensins are antimicrobial peptides produced by cells as part of the host9s immune defense system against invading pathogens. A Perspective by Tomas Ganz highlights three papers that provide new insights into the structure and function of vertebrate defensins. In mice, a-defensins produced by the Paneth cells of the small intestine help defend
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Defensins are antimicrobial peptides produced by cells as part of the host9s immune defense system against invading pathogens. A Perspective by Tomas Ganz highlights three papers that provide new insights into the structure and function of vertebrate defensins. In mice, a-defensins produced by the Paneth cells of the small intestine help defend
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Multispecific myeloid defensins
Current Opinion in Hematology, 2007This review describes recent progress in our understanding of defensins and their contributions to innate immunity. Defensins are small, cysteine-rich endogenous antibiotic peptides. Human neutrophils contain large amounts of three alpha-defensins (HNP-1-HNP-3), and smaller amounts of a fourth, HNP-4. Monocytes and macrophages generally lack defensins,
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1992
Antimicrobial peptides, formerly thought of as specialized products of certain bacteria and fungi, appear to be widespread in the animal kingdom, and have been found in amphibian skin, insect hemolymph, various mucosal secretions and in professional phagocytes (1).
T. Ganz, M. E. Selsted, R. I. Lehrer
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Antimicrobial peptides, formerly thought of as specialized products of certain bacteria and fungi, appear to be widespread in the animal kingdom, and have been found in amphibian skin, insect hemolymph, various mucosal secretions and in professional phagocytes (1).
T. Ganz, M. E. Selsted, R. I. Lehrer
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Defensins: The natural peptide antibiotic
Advanced Drug Delivery Reviews, 2021Xihui Gao +2 more
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Defensins: antimicrobial peptides of innate immunity
Nature Reviews Immunology, 2003Tomáš Ganz, Ganz Tomáš
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