Results 41 to 50 of about 1,887 (167)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the plasma iron concentrations in humans remain stable at 10-30 μM. While most of the iron entering blood plasma comes from recycling, appropriate amount of iron is absorbed from the diet to compensate for losses and maintain nontoxic amounts in stores.
Ganz, Tomas, Nemeth, Elizabeta
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Antimicrobial Peptides from Fish
Pharmaceuticals, 2014 Antimicrobial peptides (AMPs) are found widely distributed through Nature, and participate in the innate host defense of each species. Fish are a great source of these peptides, as they express all of the major classes of AMPs, including defensins ...
Jorge A. Masso-Silva, Gill Diamond
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Phenotyping rare hepcidin deficiency [PDF]
Blood, 2018 In this issue of Blood , Sandhu et al 1 comprehensively catalog the individual data from all reported cases of hepcidin-deficient hemochromatosis related to HAMP , HJV , and TFR2 mutations to determine their phenotype compared with HFE hemochromatosis.
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Iron regulation by hepcidin [PDF]
Journal of Clinical Investigation, 2013 Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body. Physiologically, hepcidin is controlled by iron stores, inflammation, hypoxia, and erythropoiesis. The regulation of hepcidin expression by iron is a complex process that requires the coordination of multiple proteins, including hemojuvelin, bone morphogenetic ...
Ningning, Zhao +2 more
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, EarlyView.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
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Clinical Journal of the American Society of Nephrology, 2009 Iron is the fourth most common element in the earth's crust and the most abundant transition metal in the human body. It is an essential element required for growth and survival. Maintaining the correct iron balance is crucial for health. All living organisms evolved sophisticated mechanisms to maintain appropriate iron levels in their cells and within
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Annals of Gastroenterological Surgery, EarlyView.In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura +9 more
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A tincture of hepcidin cures all: the potential for hepcidin therapeutics [PDF]
Journal of Clinical Investigation, 2010 Iron overload as a result of blood transfusions and excessive intestinal iron absorption can be a complication of chronic anemias such as β-thalassemia. Inappropriately low levels of hepcidin, a negative regulator of iron absorption and recycling, underlie the pathophysiology of the intestinal hyperabsorption. In this issue of the JCI, Gardenghi et al.
Thomas B, Bartnikas, Mark D, Fleming
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