Results 1 to 10 of about 17,123 (223)

Cellular catabolism of the iron-regulatory peptide hormone hepcidin. [PDF]

PLoS ONE, 2013
Hepcidin, a 25-amino acid peptide hormone, is the principal regulator of plasma iron concentrations. Hepcidin binding to its receptor, the iron exporter ferroportin, induces ferroportin internalization and degradation, thus blocking iron efflux from ...
Gloria Cuevas Preza, Rogelio Pinon, Tomas Ganz, Elizabeta Nemeth   +3 more
doaj   +5 more sources

Pharmacologic Inhibition of Erythrocyte Ferroportin Expression Exacerbates Plasmodium Infection [PDF]

Microorganisms
Plasmodium parasites rely on host iron for survival and replication, making host iron availability a critical determinant of malaria pathogenesis. Central to iron homeostasis is the hepcidin–ferroportin regulatory axis, where hepcidin suppresses iron ...
Sareh Zeydabadinejad, Benjamin Frederick Theis, Jun Sung Park, Amira F. Gohara, Matam Vijay-Kumar, Beng San Yeoh, Piu Saha   +6 more
doaj   +2 more sources

Hepcidin, ferroportin, and hemoglobin as predictors of iron deficiency anemia risk and perinatal outcomes in twin pregnancy [PDF]

Frontiers in Medicine
ObjectiveThis study investigated iron-deficiency anemia (IDA), third-trimester hepcidin and ferroportin levels, and perinatal outcomes in twin pregnancies.Study designPregnant women with twin gestations (n = 195) were enrolled and classified into an IDA ...
Yanling Zhong, Lin Deng, Xingyan Xu, Jinfu Zhou, Jianying Yan, Jianying Yan, Jianying Yan, Jinying Luo, Jinying Luo, Jinying Luo   +9 more
doaj   +2 more sources

Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages [PDF]

Frontiers in Immunology, 2017
Human lactoferrin (hLf), an 80-kDa multifunctional iron-binding cationic glycoprotein, is constitutively secreted by exocrine glands and by neutrophils during inflammation. hLf is recognized as a key element in the host immune defense system.
Antimo Cutone, Luigi Rosa, Maria Stefania Lepanto, Mellani Jinnett Scotti, Francesca Berlutti, Maria Carmela Bonaccorsi di Patti, Giovanni Musci, Piera Valenti   +7 more
doaj   +4 more sources

Twenty Years of Ferroportin Disease: A Review or An Update of Published Clinical, Biochemical, Molecular, and Functional Features

Pharmaceuticals, 2019
Iron overloading disorders linked to mutations in ferroportin have diverse phenotypes in vivo, and the effects of mutations on ferroportin in vitro range from loss of function (LOF) to gain of function (GOF) with hepcidin resistance.
Roel Janssen, Edouard Bardou-Jacquet, Houda Hamdi-Rozé   +2 more
exaly   +3 more sources

Polychlorinated Biphenyl 138 Induces Toxicant-Associated Steatohepatitis via Hepatic Iron Overload and Adipose Inflammation [PDF]

Toxics
Toxicant-associated steatohepatitis (TASH) is caused by environmental toxicants rather than metabolic factors; however, its pathogenic mechanisms remain poorly understood.
Hyeon Jeong Hwang, Mi Hwa Lee, Seung Hui Lee, Byung-Jun Sung, Joong-Gook Kim, Dae Yun Seo, Dae Young Hur, Young Hyun Yoo, JaeHun Cheong, Hye Young Kim   +9 more
doaj   +2 more sources

UBA6 and NDFIP1 regulate the degradation of ferroportin

Haematologica, 2021
Hepcidin regulates iron homeostasis by controlling the level of ferroportin, the only membrane channel that facilitates export of iron from within cells.
Lisa Traeger, Steffen B. Wiegand, Andrew J. Sauer, Benjamin H.P. Corman, Kathryn M. Peneyra, Florian Wunderer, Anna Fischbach, Aranya Bagchi, Rajeev Malhotra, Warren M. Zapol, Donald B. Bloch   +10 more
doaj   +1 more source

Tissue‐Specific Regulation of Ferroportin in Wild‐Type and Hjv‐/‐ Mice Following Dietary Iron Manipulations

Hepatology Communications, 2021
Hepcidin is a liver‐derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin, which blocks iron transport and tags ferroportin for degradation.
Angeliki Katsarou, Konstantinos Gkouvatsos, Carine Fillebeen, Kostas Pantopoulos   +3 more
doaj   +1 more source

Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages. [PDF]

PLoS Pathogens, 2014
Leishmania parasites infect macrophages, cells that play an important role in organismal iron homeostasis. By expressing ferroportin, a membrane protein specialized in iron export, macrophages release iron stored intracellularly into the circulation ...
Rym Ben-Othman, Andrew R Flannery, Danilo C Miguel, Diane M Ward, Jerry Kaplan, Norma W Andrews   +5 more
doaj   +1 more source

A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

eLife, 2022
The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not
Edouard Charlebois, Carine Fillebeen, Angeliki Katsarou, Aleksandr Rabinovich, Kazimierz Wisniewski, Vivek Venkataramani, Bernhard Michalke, Anastasia Velentza, Kostas Pantopoulos   +8 more
doaj   +1 more source