Results 1 to 10 of about 12,274 (205)
UBA6 and NDFIP1 regulate the degradation of ferroportin
Haematologica, 2021 Hepcidin regulates iron homeostasis by controlling the level of ferroportin, the only membrane channel that facilitates export of iron from within cells.
Lisa Traeger +10 more
doaj +5 more sources
Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction
Frontiers in Pharmacology, 2017 The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes. Inflammatory disorders and malignancies are often associated with high hepcidin levels,
Kaustav Biswas +2 more
exaly +4 more sources
Pharmacologic Inhibition of Erythrocyte Ferroportin Expression Exacerbates Plasmodium Infection [PDF]
MicroorganismsPlasmodium parasites rely on host iron for survival and replication, making host iron availability a critical determinant of malaria pathogenesis. Central to iron homeostasis is the hepcidin–ferroportin regulatory axis, where hepcidin suppresses iron ...
Sareh Zeydabadinejad +6 more
doaj +3 more sources
Hepcidin, ferroportin, and hemoglobin as predictors of iron deficiency anemia risk and perinatal outcomes in twin pregnancy [PDF]
Frontiers in MedicineObjectiveThis study investigated iron-deficiency anemia (IDA), third-trimester hepcidin and ferroportin levels, and perinatal outcomes in twin pregnancies.Study designPregnant women with twin gestations (n = 195) were enrolled and classified into an IDA ...
Yanling Zhong +9 more
doaj +2 more sources
Pharmaceuticals, 2019 Iron overloading disorders linked to mutations in ferroportin have diverse phenotypes in vivo, and the effects of mutations on ferroportin in vitro range from loss of function (LOF) to gain of function (GOF) with hepcidin resistance.
Roel Janssen +2 more
exaly +3 more sources
Hepatology Communications, 2021 Hepcidin is a liver‐derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin, which blocks iron transport and tags ferroportin for degradation.
Angeliki Katsarou +3 more
doaj +1 more source
Cellular catabolism of the iron-regulatory peptide hormone hepcidin. [PDF]
PLoS ONE, 2013 Hepcidin, a 25-amino acid peptide hormone, is the principal regulator of plasma iron concentrations. Hepcidin binding to its receptor, the iron exporter ferroportin, induces ferroportin internalization and degradation, thus blocking iron efflux from ...
Gloria Cuevas Preza +3 more
doaj +1 more source
Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages. [PDF]
PLoS Pathogens, 2014 Leishmania parasites infect macrophages, cells that play an important role in organismal iron homeostasis. By expressing ferroportin, a membrane protein specialized in iron export, macrophages release iron stored intracellularly into the circulation ...
Rym Ben-Othman +5 more
doaj +1 more source
eLife, 2022 The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not
Edouard Charlebois +8 more
doaj +1 more source
Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms. [PDF]
PLoS Computational Biology, 2017 Systemic iron levels must be maintained in physiological concentrations to prevent diseases associated with iron deficiency or iron overload. A key role in this process plays ferroportin, the only known mammalian transmembrane iron exporter, which ...
Mihaela Enculescu +6 more
doaj +1 more source