Results 31 to 40 of about 12,274 (205)

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms [PDF]

, 2020
The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by inducing the internalization and degradation of ferroportin1 ...
Dror, Ron O, Azumaya, Caleigh M, Cheng, Yifan, Kretsch, Rachael C, Manglik, Aashish, Billesbølle, Christian B, Powers, Alexander S, Gonen, Shane, Arvedson, Tara, Schneider, Simon   +9 more
core   +1 more source

Ferroportin depletes iron needed for cell cycle progression in head and neck squamous cell carcinoma

Frontiers in Oncology, 2023
IntroductionFerroportin (FPN), the only identified eukaryotic iron efflux channel, plays an important role in iron homeostasis and is downregulated in many cancers.
Benjamin Ross Belvin, Janina P. Lewis, Janina P. Lewis, Janina P. Lewis   +3 more
doaj   +1 more source

Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: a case report

BMC Gastroenterology, 2021
Background Hereditary hemochromatosis is a heterogenous group of inherited iron-overload conditions that is characterized by increased intestinal absorption and deposition in vital organs.
Sohji Nishina, Yasuyuki Tomiyama, Katsuya Ikuta, Yasuaki Tatsumi, Yasumichi Toki, Ayako Kato, Koichi Kato, Naoko Yoshioka, Kyo Sasaki, Yuichi Hara, Keisuke Hino   +10 more
doaj   +1 more source

Iron-tracking strategies: Chaperones capture iron in the cytosolic labile iron pool

Frontiers in Molecular Biosciences, 2023
Cells express hundreds of iron-dependent enzymes that rely on the iron cofactors heme, iron-sulfur clusters, and mono-or di-nuclear iron centers for activity.
Caroline C. Philpott, Olga Protchenko, Yubo Wang, Lorena Novoa-Aponte, Andres Leon-Torres, Samantha Grounds, Amber J. Tietgens   +6 more
doaj   +1 more source

Isolation and thermal stabilization of mouse ferroportin [PDF]

FEBS Open Bio, 2020
Ferroportin (Fpn) is an essential mammalian iron transporter that is negatively regulated by the hormone hepcidin. Our current molecular understanding of Fpn‐mediated iron efflux and regulation is limited due to a lack of biochemical, biophysical and high‐resolution structural studies.
Chandrika N. Deshpande, Corbin R. Azucenas, Bo Qiao, Norimichi Nomura, Vicky Xin, Josep Font, So Iwata, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka   +10 more
openaire   +4 more sources

Lipid raft-dependent endocytosis: a new route for hepcidin-mediated regulation of ferroportin in macrophages

Haematologica, 2010
Background Expression of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and is decreased by hepcidin. We previously showed that ferroportin is present in specific cell surface domains suggestive of lipid ...
Anne Auriac, Alexandra Willemetz, François Canonne-Hergaux   +2 more
doaj   +1 more source

Oligomerization of ferroportin and the mechanism of autosomal dominance in ferroportin disease

The FASEB Journal, 2018
Ferroportin (Fpn)—the only known cellular iron‐export protein—plays a critical role in iron homeostasis by mediating iron export from macrophages and enterocytes. Rare, loss‐of‐function mutations in human Fpn (e.g. V160del) cause classical ferroportin disease, characterized by macrophage iron loading and iron‐restricted anemia ...
John P. Bonamer, T Alex Ruwe, Bo Qiao, Kyle R. Vieth, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie   +6 more
openaire   +1 more source

Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

Clinical and Translational Medicine, 2021
Background Ferroptosis is essential to regulate tumor growth and serves as a promising therapeutic target to lung cancer. Ubiquitin‐specific protease 35 (USP35) belongs to the deubiquitinases family that is associated with cell proliferation and mitosis.
Zheng Tang, Wanli Jiang, Ming Mao, Jinping Zhao, Jiakuan Chen, Nitao Cheng   +5 more
doaj   +1 more source

Ferrostatin-1 Ameliorates Liver Dysfunction via Reducing Iron in Thioacetamide-induced Acute Liver Injury in Mice

Frontiers in Pharmacology, 2022
Background and Aims: Hepatic iron overload always leads to oxidative stress, which has been found to be involved in the progression of liver disease. However, whether iron disorder is involved in acute liver disease and the further molecular mechanisms ...
Hui Jiang, Xinyu Zhang, Wanping Yang, Meiqi Li, Guohua Wang, Qianqian Luo   +5 more
doaj   +1 more source

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position −7007 of the FPN1 promoter

Haematologica, 2010
Background Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported ...
Samuele Marro, Deborah Chiabrando, Erika Messana, Jens Stolte, Emilia Turco, Emanuela Tolosano, Martina U. Muckenthaler   +6 more
doaj   +1 more source