Results 31 to 40 of about 17,123 (223)
The dynamics of hepcidin‐ferroportin internalization and consequences of a novel ferroportin disease mutation [PDF]
American Journal of Hematology, 2017 AbstractThe hepcidin‐ferroportin axis underlies the pathophysiology of many iron‐associated disorders and is a key target for the development of therapeutics for treating iron‐associated disorders. The aims of this study were to investigate the dynamics of hepcidin‐mediated ferroportin internalization and the consequences of a novel disease‐causing ...
Daniel F. Wallace +5 more
openaire +3 more sources
Haematologica, 2010 Background Expression of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and is decreased by hepcidin. We previously showed that ferroportin is present in specific cell surface domains suggestive of lipid ...
Anne Auriac +2 more
doaj +1 more source
Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin
Clinical and Translational Medicine, 2021 Background Ferroptosis is essential to regulate tumor growth and serves as a promising therapeutic target to lung cancer. Ubiquitin‐specific protease 35 (USP35) belongs to the deubiquitinases family that is associated with cell proliferation and mitosis.
Zheng Tang +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background and Aims: Hepatic iron overload always leads to oxidative stress, which has been found to be involved in the progression of liver disease. However, whether iron disorder is involved in acute liver disease and the further molecular mechanisms ...
Hui Jiang +5 more
doaj +1 more source
Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis [PDF]
International Journal of Molecular Sciences, 2021 Despite its abundance in the environment, iron is poorly bioavailable and subject to strict conservation and internal recycling by most organisms. In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with ...
Nemeth, Elizabeta, Ganz, Tomas
openaire +4 more sources
Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction
Frontiers in Pharmacology, 2017 The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes. Inflammatory disorders and malignancies are often associated with high hepcidin levels,
Sandra L. Ross +7 more
doaj +1 more source
Hepcidin and iron homeostasis during pregnancy. [PDF]
, 2014 Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke +4 more
core +1 more source
Haematologica, 2010 Background Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported ...
Samuele Marro +6 more
doaj +1 more source
The Role of Copper in the Regulation of Ferroportin Expression in Macrophages
Cells, 2021 The critical function of ferroportin (Fpn) in maintaining iron homeostasis requires complex and multilevel control of its expression. Besides iron-dependent cellular and systemic control of Fpn expression, other metals also seem to be involved in ...
Aneta Jończy +6 more
doaj +1 more source
Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. [PDF]
, 2014 Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further
Diaz-Ochoa, Vladimir E +3 more
core +2 more sources