Results 51 to 60 of about 17,123 (223)

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

eLife, 2016
Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively.
Samira Lakhal-Littleton, Magda Wolna, Yu Jin Chung, Helen C Christian, Lisa C Heather, Marcella Brescia, Vicky Ball, Rebeca Diaz, Ana Santos, Daniel Biggs, Kieran Clarke, Benjamin Davies, Peter A Robbins   +12 more
doaj   +1 more source

TAM-ing the CIA—Tumor-Associated Macrophages and Their Potential Role in Unintended Side Effects of Therapeutics for Cancer-Induced Anemia

Frontiers in Oncology, 2021
Cancer-induced anemia (CIA) is a common consequence of neoplasia and has a multifactorial pathophysiology. The immune response and tumor treatment, both intended to primarily target malignant cells, also affect erythropoiesis in the bone marrow.
Stefan Weiler, Stefan Weiler, Manfred Nairz   +2 more
doaj   +1 more source

Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages. [PDF]

, 2014
Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system.
Alessandra Frioni, Antimo Cutone, B Mazumder, B Scorneaux, D Legrand, D Legrand, DM Ward, E Nemeth, EF Barber, F Yang, Francesca Berlutti, G Cairo, G Corna, Giovanni Musci, I Domenico De, I Theurl, L Haversen, Maria Carmela Bonaccorsi di Patti, MC Bonaccorsi di Patti, P Puddu, P Puddu, P Urrutia, Piera Valenti, S Recalcati, SL Ludwiczek, SL Ross, T Ganz, T Persichini   +27 more
core   +1 more source

Airway Epithelial Cells Differentially Adapt Their Iron Metabolism to Infection With Klebsiella pneumoniae and Escherichia coli In Vitro

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundPneumonia is often elicited by bacteria and can be associated with a severe clinical course, respiratory failure and the need for mechanical ventilation.
Philipp Grubwieser, Alexander Hoffmann, Alexander Hoffmann, Richard Hilbe, Markus Seifert, Thomas Sonnweber, Nina Böck, Igor Theurl, Günter Weiss, Günter Weiss, Manfred Nairz   +10 more
doaj   +1 more source

Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events [PDF]

, 2013
Peer reviewedPublisher ...
A Matusch, A Mencacci, AE Armitage, Alistair J. P. Brown, AM Thomson, Andrea Raab, AS Ibrahim, B Spellberg, BD Corbin, CH Park, CJ Barelle, CM Lloyd, CP Smith, D Kaloriti, D Suckau, Dagmar S. Urgast, David Stead, DD Haines, DH Navarathna, DM Barry, DM MacCallum, DM MacCallum, Donna M. MacCallum, DS Urgast, ED Weinberg, EE Johnson, EH Seeley, G Kovtunovych, GD Brown, GO Latunde-Dada, H Drakesmith, H Haas, H Wang, HI Feldman, IV Ene, JC Sardi, JF McManus, JM El HageChahine, Joanna Potrykus, Jörg Feldmann, M Ogawa, MC Lorenz, MD Maines, MI Hood, MJ Marakalala, ML Pendrak, N Ramanan, N Van Rooijen, NA Gow, Nico van Rooijen, P Heymann, Q Qian, R Santos, RJ Ward, RS Almeida, S Shimma, SA Knight, Scott G. Filler, T Roemer, W Fonzi, WH Jung   +60 more
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Role of Ferroportin in Macrophage-Mediated Immunity [PDF]

Infection and Immunity, 2010
ABSTRACT Perturbations in iron metabolism have been shown to dramatically impact host response to infection. The most common inherited iron overload disorder results from defects in the HFE gene product, a major histocompatibility complex class I-like protein that interacts with transferrin receptors.
Johnson, Erin E., Sandgren, Andreas, Cherayil, Bobby J., Murray, Megan, Wessling-Resnick, Marianne   +4 more
openaire   +3 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Genetic and clinical heterogeneity of ferroportin disease [PDF]

British Journal of Haematology, 2005
SummaryFerroportin is encoded by the SLC40A1 gene and mediates iron export from cells by interacting with hepcidin. SLC40A1 gene mutations are associated with an autosomal type of genetic iron overload described as haemochromatosis type 4, or HFE4 (Online Mendelian Inheritance in Man number 606069), or ferroportin disease. We report three families with
L, Cremonesi, Laura, Cemonesi, Gian Luca, Forni, Nadia, Soriani, Martina, Lamagna, Isabella, Fermo, Filomena, Daraio, Anna, Galli, Daniela, Pietra, Luca, Malcovati, Maurizio, Ferrari, Clara, Camaschella, Mario, Cazzola   +12 more
openaire   +4 more sources

Iron metabolism and laboratory testing for iron status [PDF]

Medicinski Podmladak, 2016
Under normal circumstances, 1-2 mg of iron enters and leaves the body each day. Iron is absorbed in the duodenum, as heme and non-heme iron (Fe+2). Due to its ability to participate in redox-reactions, iron possesses toxic properties.
Ćorić Vesna
doaj   +1 more source