Results 71 to 80 of about 17,123 (223)
Impaired iron recycling from erythrocytes is an early hallmark of aging
eLife, 2023 Aging affects iron homeostasis, as evidenced by tissue iron loading and anemia in the elderly. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by splenic red pulp macrophages ...
Patryk Slusarczyk +16 more
doaj +1 more source
Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3) [PDF]
, 2002 We describe a family with autosomal dominant inheritance of increased body iron stores characterized by raised serum ferritin concentration and normal transferrin saturation. Liver biopsy showed iron deposition in Kupffer cells without fibrosis.
Carter, Kymberley +6 more
core +1 more source
Increased calcification by erythrophagocytosis in aortic valvular interstitial cells
ESC Heart Failure, Volume 12, Issue 2, Page 1469-1473, April 2025.Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin +3 more
wiley +1 more source
RNF217: brokering ferroportin degradation [PDF]
Blood, 2021 Nermi L. Parrow, Robert E. Fleming
openaire +2 more sources
Ferroportin disease: pathogenesis, diagnosis and treatment
Haematologica, 2017 Ferroportin Disease (FD) is an autosomal dominant hereditary iron loading disorder associated with heterozygote mutations of the ferroportin-1 (FPN) gene. It represents one of the commonest causes of genetic hyperferritinemia, regardless of ethnicity. FPN1 transfers iron from the intestine, macrophages and placenta into the bloodstream.
openaire +5 more sources
Iron Matryoshka—Haemochromatosis nested in Ferroportin Disease? [PDF]
Liver International, 2019 See Article on Page ...
André Viveiros +3 more
openaire +2 more sources
A Novel Muscle Atrophy Mechanism: Myocyte Degeneration Due to Intracellular Iron Deprivation
Cells, 2022 Muscle atrophy is defined as the progressive degeneration or shrinkage of myocytes and is triggered by factors such as aging, cancer, injury, inflammation, and immobilization.
Dae Keun Suh +7 more
doaj +1 more source
Journal of the Chinese Chemical Society, EarlyView.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease
Blood, 2007 Abstract Ferroportin disease is caused by mutation of one allele of the iron exporter ferroportin (Fpn/IREG1/Slc40a1/MTP1). All reported human mutations are missense mutations and heterozygous null mutations in mouse Fpn do not recapitulate the human disease. Here we describe the flatiron (ffe) mouse with a missense mutation (H32R) in
Irene E, Zohn +8 more
openaire +3 more sources
Pharmacological Targeting of the Hepcidin/Ferroportin Axis [PDF]
Frontiers in Pharmacology, 2016 The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells. Hepcidin insufficiency causes hyperabsorption of dietary iron, hyperferremia and tissue iron overload, which are hallmarks of hereditary hemochromatosis.
Sebastiani, Giada +2 more
openaire +2 more sources