Results 91 to 100 of about 12,274 (205)
Cellular iron: Ferroportin is the only way out
, 2005 Ferroportin is the sole cellular efflux channel for iron and is regulated by the iron regulatory hormone hepcidin, which binds ferroportin and induces its internalization and degradation.
Ganz, Tomas
core +1 more source
The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song +6 more
wiley +1 more source
RNF217: brokering ferroportin degradation [PDF]
Blood, 2021 Nermi L. Parrow, Robert E. Fleming
openaire +2 more sources
Ferroportin in Omniscan-injected mice.
, 2015 Omniscan significantly induces the iron transport protein “ferroportin” in mouse skin. Deferiprone treatment markedly decreases Omniscan-induced ferroportin expression in the mouse skin biopsies.
Oleg Karaduta (787139) +6 more
core +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell +3 more
wiley +1 more source
ToxicsToxicant-associated steatohepatitis (TASH) is caused by environmental toxicants rather than metabolic factors; however, its pathogenic mechanisms remain poorly understood.
Hyeon Jeong Hwang +9 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Hereditary hemochromatosis (HH) is an inherited disorder of iron metabolism characterized by progressive iron accumulation in multiple organs. While most cases are associated with HFE mutations, non‐HFE variants such as mutations in the transferrin receptor‐2 (TFR2) gene represent rare causes of iron overload.
Omar M. Raslan, Dana S. Alamoudi
wiley +1 more source
Ferroportin expression in Macrophages.
, 2015 Rat peritoneal macrophages were obtained as described in the methods. The cells were harvested after a 6-hour exposure to 0.1 mg/ml elemental iron from the different iron compounds in the presence or absence of 500nM hepcidin. The data show that exposure
Becky Webb (738921) +4 more
core +1 more source
Ferroptosis in breast cancer: From adipocyte–immune–iron regulation to therapeutic application
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.Ferroptosis in breast cancer is regulated by an integrated adipocyte–immune–iron network rather than by tumour‐intrinsic pathways alone. Adipocyte‐derived lipid substrates and redox metabolites, immune‐cell‐mediated cytokine signalling and iron‐dependent oxidative stress collectively shape a dynamic ferroptosis ecosystem that can shift tumours towards ...
Juan Sun, Yang Qu, Ru Yao, Yidong Zhou
wiley +1 more source
A bacterial homologue of the human iron exporter ferroportin
, 2015 A bacterial homologue of the human iron exporter ferroportin found in the predatory Gram-negative bacterium Bdellovibrio bacteriovorus has been investigated.
Furbetta, Pier Antonio +4 more
core +1 more source