Results 91 to 100 of about 17,123 (223)

Silencing airway epithelial cell-derived hepcidin exacerbates sepsis-induced acute lung injury [PDF]

, 2014
INTRODUCTION: The production of antimicrobial peptides by airway epithelial cells is an important component of the innate immune response to pulmonary infection and inflammation. Hepcidin is a β-defensin-like antimicrobial peptide and acts as a principal
Cong Li Zeng, Jun Lu Wang, Qi Xing Chen, Qing Hua Chen, Sheng Wen Song, Xia Zheng, Xiang Ming Fang   +6 more
core   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Decreased expression of ferroportin in prostate cancer

Oncology Letters, 2015
The present study examined the expression levels of ferroportin, a transmembrane protein that transports iron from the inside of a cell to the outside, in the prostate cancer PC3, DU145 and LNCAP cell lines, in the normal prostate RWPE2 cell line, and in tissue samples from different differentiation stages of prostatic carcinoma and prostatic ...
Xue, Dong, Zhou, Cui-Xing, Shi, Yun-Bo, Lu, Hao, He, Xiao-Zhou   +4 more
openaire   +3 more sources

How does hepcidin hinder ferroportin activity? [PDF]

Blood, 2018
In this issue of Blood , Aschemeyer et al found that hepcidin bound to the central cavity of ferroportin (Fpn) and occluded its iron export activity, thereby revealing a previously unrecognized mechanism for Fpn regulation ...
De-Liang Zhang, Tracey A. Rouault
openaire   +2 more sources

Macrophage ferroportin is essential for stromal cell proliferation in wound healing

Haematologica, 2019
Iron recycling by macrophages is essential for erythropoiesis, but may also be relevant for iron redistribution to neighboring cells at the local tissue level.
Stefania Recalcati, Elena Gammella, Paolo Buratti, Andrea Doni, Achille Anselmo, Massimo Locati, Gaetano Cairo   +6 more
doaj   +1 more source

Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains

Physiological Reports, 2020
C57BL/6 (BL6) and Balb/c mice exhibit prototypical Th1‐ and Th2‐dominant immune predispositions, respectively. Iron is a proinflammatory metal ion; however, limited information is documented on the differences in iron homeostasis between BL6 and Balb/c ...
Piu Saha, Xia Xiao, Yaqi Li, Rachel M. Golonka, Ahmed A. Abokor, Beng San Yeoh, Matam Vijay‐Kumar   +6 more
doaj   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

The effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat [PDF]

, 2013
Background Iron deficiency anaemia during pregnancy is a global problem, with short and long term consequences for maternal and child health. Animal models have demonstrated that the developing fetus is vulnerable to maternal iron restriction, impacting
Cornock, Ruth, Gambling, Lorraine, Langley-Evans, Simon C., McArdle, Harry J., McMullen, Sarah   +4 more
core   +4 more sources

Iron Overload: Pathophysiology, Diagnosis and Monitoring

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Iron overload is associated with significant health risks, underscoring the importance of understanding its pathophysiology as well as establishing accurate diagnostic and monitoring methods. Chronic iron overload is associated with either genetic disorders characterized by excessive iron accumulation (hereditary hemochromatosis), or is ...
Elena Chatzikalil, Polyxeni Delaporta, Konstantinos Bistas, Antonis Kattamis   +3 more
wiley   +1 more source

Haemochromatosis ‐ a modern clinician’s guide

Internal Medicine Journal, EarlyView.
Abstract Haemochromatosis is an inherited disorder of iron metabolism affecting approximately 100 000 Australians. Iron overload may result in end organ dysfunction, most commonly manifesting as chronic liver disease, arthropathy and endocrinopathies. End organ complications can be prevented, minimised or reversed, with early diagnosis and initiation ...
James G. Fiori, John K. Olynyk
wiley   +1 more source