Results 111 to 120 of about 12,274 (205)

Iron Dysregulation in Alzheimer’s Disease: LA-ICP-MS Bioimaging of the Distribution of Iron and Ferroportin in the CA1 Region of the Human Hippocampus

Biomolecules
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by cognitive decline and neuropathological hallmarks, including β-amyloid (Aβ) plaques, Tau tangles, synaptic dysfunction and neurodegeneration.
Susana Junceda, María Cruz-Alonso, Beatriz Fernandez, Rosario Pereiro, Eva Martínez-Pinilla, Ana Navarro   +5 more
doaj   +1 more source

Ferroportin disease: A systematic meta-analysis of clinical and molecular findings. [PDF]

, 2010
Background & Aims: Classical ferroportin disease is characterized by hyperferritinemia, normal transferrin saturation, and iron overload in macrophages.
Griffiths, William J.H., Janecke AR, Zoller H., Zoller, Heinz, Andreas R. Janecke, Vogel, Wolfgang, Mayr R, PIETRANGELO, Antonello, Vogel W, Melanie Schranz, Wolfgang Vogel, Griffiths WJH, Antonello Pietrangelo, William J.H. Griffiths, Schranz, Melanie, Roman Mayr, Heinz Zoller, Mayr, Roman, Janecke, Andreas R., Schranz M   +19 more
core   +1 more source

Iron overload due to mutations in ferroportin.

Haematologica, 2006
Iron overload disease due to mutations in ferroportin has a dominant inheritance and a variable clinical phenotype, such that some patients show early Küpffer cell iron loading and low transferrin saturation, while others show hepatocyte iron loading and high transferrin saturation.
I. DE DOMENICO, D. MCVEY WARD, MUSCI, Giovanni, J. KAPLAN   +3 more
openaire   +2 more sources

Hepcidin-ferroportin axis in health and disease

, 2019
Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves binding ferroportin, the main iron export protein, resulting in its internalization and degradation and leading to iron sequestration within ferroportin-expressing cells.
openaire   +3 more sources

Structural studies on human ferroportin

, 2014
La ferroportina è una proteina politopica di membrana di 62,5 kDa che media l’esporto del ferro ferroso da cellule specializzate dell’organismo alla circolazione sanguigna.
Cece, Giovanna
core  

Ceruloplasmin-ferroportin system of iron traffic in vertebrates

, 2014
Safe trafficking of iron across the cell membrane is a delicate process that requires specific protein carriers. While many proteins involved in iron uptake by cells are known, only one cellular iron export protein has been identified in mammals ...
Musci G, BONACCORSI DI PATTI, Maria Carmela, Polticelli F   +2 more
core   +1 more source

Development of a molecular-clinical predictive model for iron overload complications in beta-thalassemia major: Integrating transferrin receptor-2, ferroportin, soluble transferrin receptor, and toxic iron species (nontransferrin-bound iron)

Iraqi Journal of Hematology
BACKGROUND: Beta-thalassemia major (β-TM) is a hereditary blood disorder requiring lifelong blood transfusions, which result in iron overload and progressive organ damage.
Omar Ali Hussein, Twana Ahmed Mustafa, Sulaiman Yousif Abdulrahman Alomar   +2 more
doaj   +1 more source

Serum copper and ferroportin in monocytes of hemodialysis patients are both decreased but unassociated

, 2014
Disturbed iron homeostasis contributes to resistance to recombinant human erythropoietin (rHuEpo) in hemodialysis (HD) patients. Although increased hepcidin, which downregulates the iron exporter ferroportin, had been incriminated, such an association ...
Pissas, G., Spanoulis, A., Golfinopoulos, S., Filippidis, G., Stefanidis, I., Eleftheriadis, T., Liakopoulos, V., Antoniadi, G.   +7 more
core   +1 more source

Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types

, 2017
Hepcidin is a small cysteine rich peptide that regulates the sole known cellular iron exporter, ferroportin, effectively controlling iron metabolism. Contrary to humans, where a single hepcidin exists, many fish have two functionally distinct hepcidin ...
Pedro N. S. Rodrigues, João V. Neves, Maria S. Gomes, Ana C. Moreira, Tânia Silva, Miguel F. Ramos   +5 more
core   +1 more source

Ferroportin gene silencing induces iron retention and enhances ferritin synthesis in human macrophages

, 2004
Missense mutations in the ferroportin gene (SLC11A3) result in haemochromatosis type 4 [HFE4, Online Mendelian Inheritance in Man (OMIM) reference 606069] or ferroportin disease, an autosomal dominant disorder characterized by predominantly ...
CAZZOLA, MARIO, BIASIOTTO, Giorgio, AROSIO, Paolo, CAZZOLA M., SANTAMBROGIO P, GALLI A, BERGAMASCHI G, Arosio P, BOGGI S, LEVI S, RECALDE H, Biasiotto G   +11 more
core   +1 more source