Results 131 to 140 of about 17,123 (223)

A hepcidin, egy máj által termelt hormon szerepe a vasanyagcsere szabályozásában = The role of hepcidin, a liver-produced hormone in the regulation of iron metabolism [PDF]

, 2010
A hepcidin az emlős szervezetekben található a közelmúltban felfedezett hormon, amelynek két fő funkciója van emlősökben: rendelkezik egy antimikrobiális hatással és szabályozza a szervezet vasanyagcseréjét.
Debreceni, Balázs, Mózsik, Gyula, Sipos, Katalin   +2 more
core  

Iron Dysregulation in Alzheimer’s Disease: LA-ICP-MS Bioimaging of the Distribution of Iron and Ferroportin in the CA1 Region of the Human Hippocampus

Biomolecules
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by cognitive decline and neuropathological hallmarks, including β-amyloid (Aβ) plaques, Tau tangles, synaptic dysfunction and neurodegeneration.
Susana Junceda, María Cruz-Alonso, Beatriz Fernandez, Rosario Pereiro, Eva Martínez-Pinilla, Ana Navarro   +5 more
doaj   +1 more source

Molecular and cellular insights into iron regulation [PDF]

, 2012
The iron hormone hepcidin is regarded as the main iron homeostatic regulator in the human body. It is predominantly produced by hepatocytes in response to systemic iron excess.
Mehta, K., Mehta, K.
core   +1 more source

Hepcidin-ferroportin axis in health and disease

, 2019
Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves binding ferroportin, the main iron export protein, resulting in its internalization and degradation and leading to iron sequestration within ferroportin-expressing cells.
openaire   +3 more sources

Development of a molecular-clinical predictive model for iron overload complications in beta-thalassemia major: Integrating transferrin receptor-2, ferroportin, soluble transferrin receptor, and toxic iron species (nontransferrin-bound iron)

Iraqi Journal of Hematology
BACKGROUND: Beta-thalassemia major (β-TM) is a hereditary blood disorder requiring lifelong blood transfusions, which result in iron overload and progressive organ damage.
Omar Ali Hussein, Twana Ahmed Mustafa, Sulaiman Yousif Abdulrahman Alomar   +2 more
doaj   +1 more source

Iron overload due to mutations in ferroportin.

Haematologica, 2006
Iron overload disease due to mutations in ferroportin has a dominant inheritance and a variable clinical phenotype, such that some patients show early Küpffer cell iron loading and low transferrin saturation, while others show hepatocyte iron loading and high transferrin saturation.
I. DE DOMENICO, D. MCVEY WARD, MUSCI, Giovanni, J. KAPLAN   +3 more
openaire   +2 more sources

Treatment of iron deficiency anemia: practical considerations [PDF]

, 2015
Rampton, D, Taylor, S
core   +1 more source

SLC40A1- R178G mutation and ferroportin disease

Journal of Hepatology, 2011
Speletas, Matthaios, Onoufriadis, Elias, Kioumi, Anna, Germenis, Anastasios E.   +3 more
openaire   +2 more sources

Butyrate Prevents the Pathogenic Anemia‐Inflammation Circuit by Facilitating Macrophage Iron Export

Advanced Science
Most patients with inflammatory bowel disease (IBD) develop anemia, which is attributed to the dysregulation of iron metabolism. Reciprocally, impaired iron homeostasis also aggravates inflammation.
Peng Xiao, Xuechun Cai, Zhou Zhang, Ke Guo, Yuehai Ke, Ziwei Hu, Zhangfa Song, Yuening Zhao, Lingya Yao, Manlu Shen, Jingyun Li, Youling Huang, Lingna Ye, Lingjie Huang, Yu Zhang, Rongbei Liu, Mengque Xu, Xutao Xu, Yuan Zhao, Qian Cao   +19 more
doaj   +1 more source

Regulación del metabolismo del hierro: dos sistemas, un mismo objetivo

Revista Cubana de Hematología, Inmunología y Hemoterapia
La existencia humana está indisolublemente unida al hierro, que es parte de una amplia variedad de enzimas claves como catalasas, aconitasas, ribonucleótido reductasa, peroxidasas y citocromos, que explotan la flexibilidad de su química redox para ...
Mariela Forrellat Barrios
doaj