Results 121 to 130 of about 17,123 (223)

Inherited Disorders of Iron Overload

Frontiers in Nutrition, 2018
Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-derived peptide hormone. Hepcidin inhibits iron entry into plasma by binding to and inactivating the iron exporter ferroportin in target cells, such as duodenal
Kostas Pantopoulos, Kostas Pantopoulos
doaj   +1 more source

Functional analyses of recombinant mouse hepcidin-1 in cell culture and animal model

, 2013
Hepcidin is a peptide hormone that plays an important role in iron metabolism. We have produced a recombinant mouse hepcidin-1 by using baculovirus expression system.
Kalhor, H.R., Keyhanvar, N., Rezaei, A., Yazdani, Y.   +3 more
core   +1 more source

Optimising the diagnosis and the treatment of iron overload diseases [PDF]

, 2015
International audienceA number of human disorders are related to chronic iron overload, either of genetic or acquired origin. The multi-organ damage produced by iron excess leads, in adults and in children, to severe clinical consequences, affecting both
Brissot, Pierre
core   +2 more sources

EIF2α–ATF4–CHAC1 Signalling Links ER Stress to Ferroptosis in Human Aortic Smooth Muscle Cells: Mechanistic Insights and Therapeutic Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Ferroptosis—a regulated, iron‐dependent cell death driven by lipid peroxidation—has been implicated in vascular pathology, yet how endoplasmic reticulum (ER) stress couples to ferroptotic execution in vascular smooth muscle cells (VSMCs) remains unclear.
Changwen Fang, Xiaolong Du, Yadan Wang, Yiqi Jin, Wenbin Wang   +4 more
wiley   +1 more source

Pediatric Ferroportin Disease [PDF]

Journal of Pediatric Gastroenterology and Nutrition, 2016
Galicia-Poblet, Gonzalo, Cid-París, Ester, López-Andrés, Nerea, Losada-Pajares, Alba, Jurado-López, Juan-Carlos, Moreno-Carralero, María-Isabel, Morán-Jiménez, María-Josefa   +6 more
openaire   +2 more sources

A Model of the Cellular Iron Homeostasis Network Using Semi-Formal Methods for Parameter Space Exploration

, 2012
This paper presents a novel framework for the modeling of biological networks. It makes use of recent tools analyzing the robust satisfaction of properties of (hybrid) dynamical systems.
Aisen, Alexandre Donzé, Andrews, Arosio, Chen, Chifman, Cianetti, De Domenico, Donzé, Donzé, Donzé, Dycke, Epsztejn, Erlitzki, Ezio Bartocci, Funahashi, Galaris, Granvilliers, Hunt, Jean Marc Moulis, Knutson, Luca Bortolussi, Maxima, Mayr, Moirand, Nicolas Mobilia, Omholt, Shvartsman, Wang, Weissman, Éric Fanchon   +30 more
core   +1 more source

Single‐Cell Analysis of Preeclamptic Cord Blood Mononuclear Cells Revealed Activation of Heme‐Associated Signalling Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Preeclampsia is a severe gestational complication whose molecular pathogenesis remains poorly understood despite extensive research. It is now recognized that both maternal and fetal cells contribute to disease progression. Notably, single‐cell RNA sequencing of cord blood cells from preeclamptic pregnancies has not been previously ...
Polina Vishnyakova, Evgeny Karpulevich, Victoria Karyagina, Elena Gantsova, Yulia Trofimovich, Viktoriia Kiseleva, Miroslava Chirkova, Tatiana Gerashchenko, Anastasiya Lokhonina, Kamilla Muminova, Zulfiya Khodzhaeva, Evgeny Denisov, Andrey Elchaninov, Timur Fatkhudinov, Gennady Sukhikh   +14 more
wiley   +1 more source

HEPSİDİN-FERROPORTİN AKSI VE COVID-19

, 2023
Giriş: Viral pandemi döneminde COVID-19 tanısı almış hastalarda nötrofil, lenfosit, nötrofil-lenfosit oranı ile hemoglobin düzeylerinin, hastaların mortalite oranları, hastane yatış süreleri ve demografik özellikleri ile ilişkisinin değerlendirilmesi amacıyla yapılan bu çalışmada hepsidin-ferroportin aksının fizyopatolojideki yerinin irdelenmesi ...
Akan, Özden Yıldırım, Belice, Tahir
openaire   +2 more sources

The potential of deferasirox as a novel therapeutic modality in gastric cancer [PDF]

, 2016
Background: Iron is a crucial element for cell proliferation, growth, and metabolism. However, excess iron and altered iron metabolism are both associated with tumor initiation and tumor growth. Deferasirox is an oral iron chelator. Although some studies
���������
core   +1 more source

Iron Metabolism: From Health to Disease [PDF]

, 2014
Background Iron is vital for almost all living organisms by participating in a wide range of metabolic processes. However, iron concentration in body tissues must be tightly regulated since excessive iron may lead to microbial infections or cause tissue
Fernandes, Rúben, Oliveira, Fernando, Rocha, Sara   +2 more
core   +1 more source