Results 61 to 70 of about 17,123 (223)

Hepcidin antagonists for potential treatments of disorders with hepcidin excess [PDF]

, 2014
5noThe discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide.
Maria Regoni, Maura Poli, Michela Asperti, Paola Ruzzenenti, Paolo Arosio   +4 more
core   +2 more sources

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Oligomerization of ferroportin and the mechanism of autosomal dominance in ferroportin disease

The FASEB Journal, 2018
Ferroportin (Fpn)—the only known cellular iron‐export protein—plays a critical role in iron homeostasis by mediating iron export from macrophages and enterocytes. Rare, loss‐of‐function mutations in human Fpn (e.g. V160del) cause classical ferroportin disease, characterized by macrophage iron loading and iron‐restricted anemia ...
John P. Bonamer, T Alex Ruwe, Bo Qiao, Kyle R. Vieth, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie   +6 more
openaire   +1 more source

Intestinal ferroportin expression in pediatric Crohnʼs disease [PDF]

Inflammatory Bowel Diseases, 2011
Anemia is a frequent complication of Crohn's disease (CD). The intestinal iron exporter ferroportin (FPN) is involved in both iron deficiency anemia and the anemia of chronic disease. To examine its role in CD, intestinal FPN expression was studied in subjects with and without CD.Duodenal mucosal biopsies from 29 pediatric subjects with CD (n=19) and ...
Tyler, Burpee, Paul, Mitchell, Douglas, Fishman, Shabana, Islam, Elizabeta, Nemeth, Mark, Westerman, Marianne, Wessling-Resnick, Richard J, Grand   +7 more
openaire   +2 more sources

Hepcidin Therapeutics

Pharmaceuticals, 2018
Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to “hepcidinopathies„ ranging from hereditary hemochromatosis ...
Angeliki Katsarou, Kostas Pantopoulos
doaj   +1 more source

Hepcidin–Minireview [PDF]

Journal of Clinical and Diagnostic Research, 2013
Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red
Subha Palaneeswari M., M. Ganesh, T. Karthikeyan, A.J. Manjula Devi, S.V. Mythili   +4 more
doaj   +1 more source

Iron Status and Analysis of Efficacy and Safety of Ferric Carboxymaltose Treatment in Patients with Inflammatory Bowel Disease [PDF]

, 2012
Background and Aims:We analyzed iron deficiency and the therapeutic response following intravenous ferric carboxymaltose in a large single-center inflammatory bowel disease (IBD) cohort.
Anker SD, Anker SD, Beate Löhr, Breymann C, Burkhard Göke, Carrier J, Chandler G, Cornelia Tillack, De Silva AD, Domenech E, Erichsen K, Erichsen K, Evstatiev R, Fabian Schnitzler, Fleming MD, Fleming RE, Florian Beigel, Ganz T, Gasche C, Gasche C, Julia Seiderer, Katsanos K, Kociol RD, Kulnigg S, Lomer MC, Maria Weidinger, Nemeth E, Nemeth E, Pizzi LT, Qunibi WY, Qunibi WY, Rüdiger P. Laubender, Schroder O, Semrin G, Simone Breiteneicher, Srigiridhar K, Stein J, Stephan Brand, Szczech LA, Tagboto S, Thomas Ochsenkühn, Van Wyck DB, Wells CW, Werner T, Wilson A, Wilson A   +45 more
core   +1 more source

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
core   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source