Results 61 to 70 of about 12,274 (205)
Pharmaceuticals, 2018 Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to “hepcidinopathies„ ranging from hereditary hemochromatosis ...
Angeliki Katsarou, Kostas Pantopoulos
doaj +1 more source
Journal of Clinical and Diagnostic Research, 2013 Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red
Subha Palaneeswari M. +4 more
doaj +1 more source
Increased calcification by erythrophagocytosis in aortic valvular interstitial cells
ESC Heart Failure, Volume 12, Issue 2, Page 1469-1473, April 2025.Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin +3 more
wiley +1 more source
Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT [PDF]
Cell Metabolism, 2012 Ferroportin is the primary means of cellular iron efflux and a key component of iron metabolism. Hepcidin regulates Fpn activity by inducing its internalization and degradation. The mechanism of internalization is reported to require JAK2 activation, phosphorylation of Fpn tyrosine residues 302 and 303, and initiation of transcription through STAT3 ...
Ross, Sandra L. +16 more
openaire +2 more sources
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
, 2005 SummaryFerroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Hepcidin, a regulatory peptide, binds to ferroportin and causes it to be internalized and degraded.
Pinkus, Jack L. +6 more
core +1 more source
Journal of the Chinese Chemical Society, EarlyView.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
Impaired iron recycling from erythrocytes is an early hallmark of aging
eLife, 2023 Aging affects iron homeostasis, as evidenced by tissue iron loading and anemia in the elderly. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by splenic red pulp macrophages ...
Patryk Slusarczyk +16 more
doaj +1 more source
Structure and mechanism of a primate ferroportin [PDF]
, 2020 Abstract Ferroportin is the only cellular iron exporter in human and essential for iron homoeostasis. Mutations in ferroportin are associated with hemochromatosis or ferroportin diseases characterized by a paradoxical combination of anemia and abnormal accumulation of iron in cells.
Ren, Zhenning +11 more
openaire +1 more source
Ferroptosis and Its Emerging Role in Gestational Diabetes Mellitus
Medicine Advances, EarlyView.Ferroptosis contributes to the development of gestational diabetes mellitus (GDM) through iron overload, lipid peroxidation, and antioxidant system disruption. These changes impair adipocyte and β‐cell function, promoting insulin resistance and hyperglycemia.
Jinfeng Xu +4 more
wiley +1 more source
A Novel Muscle Atrophy Mechanism: Myocyte Degeneration Due to Intracellular Iron Deprivation
Cells, 2022 Muscle atrophy is defined as the progressive degeneration or shrinkage of myocytes and is triggered by factors such as aging, cancer, injury, inflammation, and immobilization.
Dae Keun Suh +7 more
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