Results 41 to 50 of about 12,274 (205)

Immunolocalization of Ferroportin in Healthy and Anemic Mice [PDF]

Journal of Histochemistry & Cytochemistry, 2008
Ferroportin (FPN), the only iron exporter identified to date, participates in iron release from enterocytes and macrophages, regulating its absorption and recycling. We used a murine model of experimental hemolytic anemia to study adaptive changes in the localization of FPN in duodenum, liver, and spleen.
D'anna, Maria Cecilia, Veuthey, Tania Vanesa, Roque, Marta Elena   +2 more
openaire   +3 more sources

The Role of Copper in the Regulation of Ferroportin Expression in Macrophages

Cells, 2021
The critical function of ferroportin (Fpn) in maintaining iron homeostasis requires complex and multilevel control of its expression. Besides iron-dependent cellular and systemic control of Fpn expression, other metals also seem to be involved in ...
Aneta Jończy, Rafał Mazgaj, Ewa Smuda, Beata Żelazowska, Zuzanna Kopeć, Rafał Radosław Starzyński, Paweł Lipiński   +6 more
doaj   +1 more source

Evidence for the multimeric structure of ferroportin

Blood, 2006
Abstract Ferroportin (Fpn) (IREG1, SLC40A1, MTP1) is an iron transporter, and mutations in Fpn result in a genetically dominant form of iron overload disease. Previously, we demonstrated that Fpn is a multimer and that mutations in Fpn are dominant negative.
I. DE DOMENICO, D. MCVEY WARD, MUSCI, Giovanni, J. KAPLAN   +3 more
openaire   +4 more sources

The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease

Blood, 2007
Abstract Ferroportin disease is caused by mutation of one allele of the iron exporter ferroportin (Fpn/IREG1/Slc40a1/MTP1). All reported human mutations are missense mutations and heterozygous null mutations in mouse Fpn do not recapitulate the human disease. Here we describe the flatiron (ffe) mouse with a missense mutation (H32R) in
Irene E, Zohn, Ivana, De Domenico, Andrew, Pollock, Diane McVey, Ward, Jessica F, Goodman, Xiayun, Liang, Amaru J, Sanchez, Lee, Niswander, Jerry, Kaplan   +8 more
openaire   +3 more sources

The molecular basis of ferroportin-linked hemochromatosis [PDF]

Proceedings of the National Academy of Sciences, 2005
Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1 , and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation. Most patients develop iron loading of Kupffer cells with relatively low saturation
DE DOMENICO I, WARD DM, NEMETH E, VAUGHN MB, MUSCI, Giovanni, GANZ T, KAPLAN J.   +6 more
openaire   +3 more sources

Hepcidin and erythroferrone response to 3 weeks of exposure to normobaric hypoxia at rest in trained cyclists

Frontiers in Physiology, 2023
Purpose: The effectiveness of altitude training on haematological adaptations is largely dependent on iron metabolism. Hepcidin and erythroferrone (ERFE) are key iron-regulating hormones, yet their response to altitude training is poorly understood.
Kamila Płoszczyca, Miłosz Czuba, Małgorzata Chalimoniuk, Konrad Witek, Marcin Baranowski   +4 more
doaj   +1 more source

Iron deficiency in parkinsonism : region-specific iron dysregulation in Parkinson's disease and multiple system atrophy [PDF]

Alpha synuclein pathology is widespread and found in diverse cell types in multiple system atrophy (MSA) as compared to Parkinson's disease (PD). The reason for this differential distribution is unknown.
Visanji, Naomi P., Finnegan, Mary E., Collingwood, Joanna F., Hazrati, Lili-Naz, Tandon, Anurag, House, Emily   +5 more
core   +1 more source

Ferroportin disease due to the A77D mutation in Australia

, 2005
Ferroportin disease or type 4 haemochroma-tosis is an autosomal dominant iron overload disorder caused by mutations in the iron exporter ...
Dixon, J.L., Fletcher, L.M., Wallace, D.F., Subramaniam, V. N., Wallace, D. F., Dixon, J. L., Crawford, D. H., Fletcher, L. M., Crawford, D.H., Subramaniam, V.N.   +9 more
core   +1 more source

G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective

, 2011
Background & Aims: Hereditary iron overload associated with mutations in the ferroportin gene produces a dichotomy of phenotypes resulting from either increase or decrease in iron efflux capacity.
Wallace, D.F., Lesa Ostini, Demediuk, Barbara, Subramaniam, V. Nathan, Sally J. Bell, Barbara Demediuk, Ostini, L., Demediuk, B., Daniel F. Wallace, Wallace, Daniel F., McDonald, Cameron J., McDonald, C.J., V. Nathan Subramaniam, Bell, S.J., Cameron J. McDonald, Bell, Sally J., Ostini, Lesa, Subramaniam, V.N.   +17 more
core   +1 more source

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

eLife, 2016
Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively.
Samira Lakhal-Littleton, Magda Wolna, Yu Jin Chung, Helen C Christian, Lisa C Heather, Marcella Brescia, Vicky Ball, Rebeca Diaz, Ana Santos, Daniel Biggs, Kieran Clarke, Benjamin Davies, Peter A Robbins   +12 more
doaj   +1 more source