Results 41 to 50 of about 17,123 (223)

Ferroportin: Lack of evidence for multimers

Blood Cells, Molecules, and Diseases, 2008
Ferroportin is a multi-transmembrane glycoprotein that mediates iron export from cells. Mutations in ferroportin are linked to type IV hemochromatosis, a dominantly inherited disorder of iron metabolism. Multimers of ferroportin, whose existence may relate to the dominant inheritance pattern of disease, have been detected in some studies but not others.
Schimanski, L, Drakesmith, H, Talbott, C, Horne, K, James, JR, Davis, S, Sweetland, E, Bastin, J, Cowley, D, Townsend, A   +9 more
openaire   +2 more sources

Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress. [PDF]

, 2018
The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs).
Bosseboeuf, E, Chikh, A, De Winter, N, Dufton, N, Gestri, G, Issitt, T, Raimondi, C, Randi, AM, Senatore, V   +8 more
core   +3 more sources

Structural basis of ion transport and inhibition in ferroportin

Nature Communications, 2020
Ferroportin is an iron exporter essential for releasing cellular iron into circulation and is inhibited by a peptide hormone, hepcidin. Here authors present cryo-EM structures of the ferroportin from the primate Philippine tarsier (TsFpn) with and ...
Yaping Pan, Zhenning Ren, Shuai Gao, Jiemin Shen, Lie Wang, Zhichun Xu, Ye Yu, Preetham Bachina, Hanzhi Zhang, Xiao Fan, Arthur Laganowsky, Nieng Yan, Ming Zhou   +12 more
doaj   +1 more source

Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: a case report

BMC Gastroenterology, 2021
Background Hereditary hemochromatosis is a heterogenous group of inherited iron-overload conditions that is characterized by increased intestinal absorption and deposition in vital organs.
Sohji Nishina, Yasuyuki Tomiyama, Katsuya Ikuta, Yasuaki Tatsumi, Yasumichi Toki, Ayako Kato, Koichi Kato, Naoko Yoshioka, Kyo Sasaki, Yuichi Hara, Keisuke Hino   +10 more
doaj   +1 more source

Hepcidin and erythroferrone response to 3 weeks of exposure to normobaric hypoxia at rest in trained cyclists

Frontiers in Physiology, 2023
Purpose: The effectiveness of altitude training on haematological adaptations is largely dependent on iron metabolism. Hepcidin and erythroferrone (ERFE) are key iron-regulating hormones, yet their response to altitude training is poorly understood.
Kamila Płoszczyca, Miłosz Czuba, Małgorzata Chalimoniuk, Konrad Witek, Marcin Baranowski   +4 more
doaj   +1 more source

Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice [PDF]

, 2017
Hepcidin, a phase II reactant secreted by hepatocytes, regulates cellular iron levels by increasing internalization of ferroportin-a transmembrane protein facilitating egress of cellular iron.
Arefiev, Yevgeniy, Chao, Robert, Chaudry, Hibba, Klug, Rebecca, Lakhani, Vishal Hari, Nawab, Athar, Nichols, Alexandra, Peterson, Stephen J., Puri, Nitin, Sacerdoti, David, Sharma, Dana, Sodhi, Komal, Srikathanan, Krithika   +12 more
core   +2 more sources

Circulatory contributors to the phenotype in hereditary hemorrhagic telangiectasia [PDF]

, 2015
Hereditary hemorrhagic telangiectasia (HHT) is mechanistically and therapeutically challenging, not only because of the molecular and cellular perturbations that generate vascular abnormalities, but also the modifications to circulatory physiology that ...
Shovlin, CL
core   +2 more sources

The molecular basis of ferroportin-linked hemochromatosis [PDF]

Proceedings of the National Academy of Sciences, 2005
Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1 , and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation. Most patients develop iron loading of Kupffer cells with relatively low saturation
DE DOMENICO I, WARD DM, NEMETH E, VAUGHN MB, MUSCI, Giovanni, GANZ T, KAPLAN J.   +6 more
openaire   +3 more sources

Ferroportin-related haemochromatosis associated with novel Y64H mutation of the SCL40A1 gene [PDF]

, 2014
In this paper we described the first Polish patient with ferroportin disease. Hereditary haemochromatosis (HH) is a condition associated with universal iron overload, and it is divided into four types, according to the Online Mendelian Inheritance in Man
Caleffi, Angela, Milkiewicz, Piotr, PIETRANGELO, Antonello, Raszeja Wyszomirska, Joanna   +3 more
core   +1 more source

Isolation and thermal stabilization of mouse ferroportin [PDF]

FEBS Open Bio, 2020
Ferroportin (Fpn) is an essential mammalian iron transporter that is negatively regulated by the hormone hepcidin. Our current molecular understanding of Fpn‐mediated iron efflux and regulation is limited due to a lack of biochemical, biophysical and high‐resolution structural studies.
Chandrika N. Deshpande, Corbin R. Azucenas, Bo Qiao, Norimichi Nomura, Vicky Xin, Josep Font, So Iwata, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka   +10 more
openaire   +4 more sources