Results 21 to 30 of about 12,274 (205)
The role of hepcidin and ferroportin in iron absorption. [PDF]
Histology and histopathology, 2007 The field of iron metabolism is moving rapidly. There have been significant advances in our understanding of how proteins carry out the process of iron absorption. The three main tissues involved in iron exchange are the enterocyte which contributes new iron to the system, the hepatocyte which stores and releases iron and the macrophages which recycles
Oates, P.S.
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Modulation of Ferroportin in Oral Cancer
, 2020 VCU Theses and ...
Hemingway, Ashley N
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Human macrophage ferroportin biology and the basis for the ferroportin disease [PDF]
Hepatology, 2017 Ferroportin (FPN1) is the sole iron exporter in mammals, but its cell‐specific function and regulation are still elusive. This study examined FPN1 expression in human macrophages, the cells that are primarily responsible on a daily basis for plasma iron turnover and are central in the pathogenesis of ferroportin disease (FD), the disease attributed to ...
M. Sabelli +6 more
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Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis [PDF]
, 2021 Despite its abundance in the environment, iron is poorly bioavailable and subject to strict conservation and internal recycling by most organisms. In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body ...
Tomas Ganz +3 more
core +1 more source
Ferroportin and Erythroid Cells: An Update [PDF]
Advances in Hematology, 2010 In recent years there have been major advances in our knowledge of the regulation of iron metabolism that have had implications for understanding the pathophysiology of some human disorders like beta-thalassemia and other iron overload diseases.
Luciano Cianetti +2 more
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Mechanism of Ca 2+ transport by ferroportin
eLife, 2022 Abstract Ferroportin (Fpn) is a transporter that releases Fe 2+ from cells and is important for iron homeostasis in circulation. Export of Fe 2+ by Fpn is coupled to import of H + to maintain charge balance ...
Jiemin Shen +3 more
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Cell Death Discovery, 2022 Compared to cancer cells, macrophages are inert to lipid peroxidation-triggered, iron-dependent cell death known as ferroptosis. Mechanisms underlying macrophage resistance towards ferroptosis are largely obscure.
Dmitry Namgaladze +2 more
doaj +1 more source
Biophysical and Cell Biological Studies Characterizing the Vertebrate Iron Exporter Ferroportin [PDF]
, 2009 Mammalian iron homeostasis is maintained by an intricate network of diverse proteins that constantly survey systemic iron levels and carefully regulate the uptake of iron from the diet. Control of this uptake is critically important because once iron is
Rice, Adrian Edward
core +1 more source
Investigating the ferroportin-ferroxidase system [PDF]
Iron is essential for various pivotal biological processes, such as oxygen transport, DNA synthesis, and ATP production. In humans, dysregulation in iron metabolism leads to severe disorders due to its intrinsic toxicity. Thus, iron homeostasis has to be tightly regulated to ensure its safe handling.
AMADEI, MATTEO
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Journal of Biomedical Science, 2023 Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier.
Stephanie L. Baringer +4 more
doaj +1 more source