Results 11 to 20 of about 12,274 (205)

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination [PDF]

Cell Metabolism, 2012
Ferroportin exports iron into plasma from absorptive enterocytes, erythrophagocytosing macrophages, and hepatic stores. The hormone hepcidin controls cellular iron export and plasma iron concentrations by binding to ferroportin and causing its internalization and degradation. We explored the mechanism of hepcidin-induced endocytosis of ferroportin, the
Qiao, Bo, Sugianto, Priscilla, Fung, Eileen, del-Castillo-Rueda, Alejandro, Moran-Jimenez, Maria-Josefa, Ganz, Tomas, Nemeth, Elizabeta   +6 more
openaire   +3 more sources

The dynamics of hepcidin‐ferroportin internalization and consequences of a novel ferroportin disease mutation [PDF]

American Journal of Hematology, 2017
AbstractThe hepcidin‐ferroportin axis underlies the pathophysiology of many iron‐associated disorders and is a key target for the development of therapeutics for treating iron‐associated disorders. The aims of this study were to investigate the dynamics of hepcidin‐mediated ferroportin internalization and the consequences of a novel disease‐causing ...
Daniel F. Wallace, Cameron J. McDonald, Lesa Ostini, David Iser, Annabel Tuckfield, V. Nathan Subramaniam   +5 more
openaire   +5 more sources

Hepcidin induces HIV-1 transcription inhibited by ferroportin [PDF]

Retrovirology, 2010
Background Physiological regulation of cellular iron involves iron export by the membrane protein, ferroportin, the expression of which is induced by iron and negatively modulated by hepcidin.
Turner Willie, Rotimi Jamie, Foster Altreisha, Kashanchi Fatah, Xu Min, Gordeuk Victor R, Nekhai Sergei   +6 more
doaj   +2 more sources

Hepcidin targets ferroportin for degradation in hepatocytes

Haematologica, 2010
Hepcidin, a circulating regulatory hormone peptide produced by hepatocytes, functions as the master regulator of cellular iron export by controlling the amount of ferroportin, an iron exporter present on the basolateral surface of intestinal enterocytes ...
Guillemette Ramey, Jean-Christophe Deschemin, Béatrice Durel, François Canonne-Hergaux, Gaël Nicolas, Sophie Vaulont   +5 more
doaj   +4 more sources

Role of Ferroportin in Macrophage-Mediated Immunity [PDF]

Infection and Immunity, 2010
ABSTRACT Perturbations in iron metabolism have been shown to dramatically impact host response to infection. The most common inherited iron overload disorder results from defects in the HFE gene product, a major histocompatibility complex class I-like protein that interacts with transferrin receptors.
Johnson, Erin E., Sandgren, Andreas, Cherayil, Bobby J., Murray, Megan, Wessling-Resnick, Marianne   +4 more
openaire   +5 more sources

A disease-causing mutation K240E disrupts ferroportin trafficking by SUMO (ferroportin SUMOylation)

Biochemistry and Biophysics Reports, 2021
Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation.
Henry K. Bayele, Surjit Kaila S. Srai
doaj   +4 more sources

Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin

Haematologica, 2013
Ferroportin Q248H mutation has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. Some investigators have reported that ferroportin Q248H is degraded after
Sergei Nekhai, Min Xu, Altreisha Foster, Ishmael Kasvosve, Sharmin Diaz, Roberto F. Machado, Oswaldo L. Castro, Gregory J. Kato, James G. Taylor, Victor R. Gordeuk   +9 more
doaj   +2 more sources

Structural basis of ion transport and inhibition in ferroportin

Nature Communications, 2020
Ferroportin is an iron exporter essential for releasing cellular iron into circulation and is inhibited by a peptide hormone, hepcidin. Here authors present cryo-EM structures of the ferroportin from the primate Philippine tarsier (TsFpn) with and ...
Yaping Pan, Zhenning Ren, Shuai Gao, Jiemin Shen, Lie Wang, Zhichun Xu, Ye Yu, Preetham Bachina, Hanzhi Zhang, Xiao Fan, Arthur Laganowsky, Nieng Yan, Ming Zhou   +12 more
doaj   +2 more sources

Ferroportin Is Essential for Iron Absorption During Suckling, But Is Hyporesponsive to the Regulatory Hormone HepcidinSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Previous studies have suggested that iron absorption in suckling mammals is refractory to stimuli that normally would decrease absorption in adults.
David M. Frazer, Sarah J. Wilkins, Deepak Darshan, Cornel S.G. Mirciov, Linda A. Dunn, Gregory J. Anderson   +5 more
doaj   +2 more sources

Genetic and clinical heterogeneity of ferroportin disease [PDF]

British Journal of Haematology, 2005
SummaryFerroportin is encoded by the SLC40A1 gene and mediates iron export from cells by interacting with hepcidin. SLC40A1 gene mutations are associated with an autosomal type of genetic iron overload described as haemochromatosis type 4, or HFE4 (Online Mendelian Inheritance in Man number 606069), or ferroportin disease. We report three families with
L, Cremonesi, Laura, Cemonesi, Gian Luca, Forni, Nadia, Soriani, Martina, Lamagna, Isabella, Fermo, Filomena, Daraio, Anna, Galli, Daniela, Pietra, Luca, Malcovati, Maurizio, Ferrari, Clara, Camaschella, Mario, Cazzola   +12 more
openaire   +5 more sources