Results 11 to 20 of about 17,123 (223)
Hepcidin targets ferroportin for degradation in hepatocytes
Haematologica, 2010 Hepcidin, a circulating regulatory hormone peptide produced by hepatocytes, functions as the master regulator of cellular iron export by controlling the amount of ferroportin, an iron exporter present on the basolateral surface of intestinal enterocytes ...
Guillemette Ramey +5 more
doaj +4 more sources
A disease-causing mutation K240E disrupts ferroportin trafficking by SUMO (ferroportin SUMOylation)
Biochemistry and Biophysics Reports, 2021 Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation.
Henry K. Bayele, Surjit Kaila S. Srai
doaj +4 more sources
Human macrophage ferroportin biology and the basis for the ferroportin disease [PDF]
Hepatology, 2017 Ferroportin (FPN1) is the sole iron exporter in mammals, but its cell‐specific function and regulation are still elusive. This study examined FPN1 expression in human macrophages, the cells that are primarily responsible on a daily basis for plasma iron turnover and are central in the pathogenesis of ferroportin disease (FD), the disease attributed to ...
M. Sabelli +6 more
openaire +2 more sources
Flatiron Mice and Ferroportin Disease [PDF]
Nutrition Reviews, 2007 Flatiron mice provide the first genetic model that fully recapitulates the iron-loading disorder ferroportin disease. Unlike the other known genetic causes of hemochromatosis, missense mutations in the ferroportin gene are autosomal dominant. These new findings show that ferroportin disease results from dominant negative effects rather than haplo ...
Erin E, Johnson +1 more
openaire +2 more sources
Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms. [PDF]
PLoS Computational Biology, 2017 Systemic iron levels must be maintained in physiological concentrations to prevent diseases associated with iron deficiency or iron overload. A key role in this process plays ferroportin, the only known mammalian transmembrane iron exporter, which ...
Mihaela Enculescu +6 more
doaj +1 more source
Cell Death Discovery, 2022 Compared to cancer cells, macrophages are inert to lipid peroxidation-triggered, iron-dependent cell death known as ferroptosis. Mechanisms underlying macrophage resistance towards ferroptosis are largely obscure.
Dmitry Namgaladze +2 more
doaj +1 more source
Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin
Haematologica, 2013 Ferroportin Q248H mutation has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. Some investigators have reported that ferroportin Q248H is degraded after
Sergei Nekhai +9 more
doaj +1 more source
Mechanism of Ca 2+ transport by ferroportin
eLife, 2022 Abstract Ferroportin (Fpn) is a transporter that releases Fe 2+ from cells and is important for iron homeostasis in circulation. Export of Fe 2+ by Fpn is coupled to import of H + to maintain charge balance ...
Jiemin Shen +3 more
openaire +4 more sources
Hepcidin and Host Defense against Infectious Diseases. [PDF]
, 2015 Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas +3 more
core +1 more source
Journal of Biomedical Science, 2023 Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier.
Stephanie L. Baringer +4 more
doaj +1 more source