Results 21 to 30 of about 315,195 (302)
Non-invasive assessment of normal and impaired iron homeostasis in the brain
Nature Communications, 2023 Strict iron regulation is essential for normal brain function. The iron homeostasis, determined by the milieu of available iron compounds, is impaired in aging, neurodegenerative diseases and cancer.
Shir Filo +9 more
doaj +1 more source
Advanced Science, 2023 Doxorubicin (DOX)‐induced cardiotoxicity (DoIC) is a major side effect for cancer patients. Recently, ferroptosis, triggered by iron overload, is demonstrated to play a role in DoIC.
Jianan Pan +11 more
doaj +1 more source
Interpreting Iron Homeostasis in Congenital and Acquired Disorders
Pharmaceuticals, 2023 Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport.
Natalia Scaramellini +5 more
doaj +1 more source
Host and microbiota derived extracellular vesicles: Crucial players in iron homeostasis
Frontiers in Medicine, 2022 Iron is a double-edged sword. It is vital for all that’s living, yet its deficiency or overload can be fatal. In humans, iron homeostasis is tightly regulated at both cellular and systemic levels.
Yasmeen Daou +8 more
doaj +1 more source
Brain Iron Homeostasis and Mental Disorders
Antioxidants, 2023 Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer.
Qiong Wu +4 more
doaj +1 more source
Antioxidants, 2021 Iron accumulation and neuroinflammation are pathological conditions found in several neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Iron and inflammation are intertwined in a bidirectional relationship, where
Pamela J. Urrutia +2 more
doaj +1 more source
Iron homeostasis during pregnancy [PDF]
The American Journal of Clinical Nutrition, 2017 During pregnancy, iron needs to increase substantially to support fetoplacental development and maternal adaptation to pregnancy. To meet these iron requirements, both dietary iron absorption and the mobilization of iron from stores increase, a mechanism that is in large part dependent on the iron-regulatory hormone hepcidin.
Fisher, Allison L, Nemeth, Elizabeta
openaire +4 more sources
Microbiology Spectrum, 2023 Zinc excess is toxic to bacteria and, thus, represents an important innate defense mechanism of host cells, especially against mycobacterial infections.
Xiaohui Li +4 more
doaj +1 more source
The Role of Sulfur in Agronomic Biofortification with Essential Micronutrients
Plants, 2022 Sulfur (S) is an essential macronutrient for plants, being necessary for their growth and metabolism and exhibiting diverse roles throughout their life cycles. Inside the plant body, S is present either in one of its inorganic forms or incorporated in an
Styliani N. Chorianopoulou +1 more
doaj +1 more source
Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress. [PDF]
, 2018 The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs).
Bosseboeuf, E +8 more
core +3 more sources