The Role of the Liver in Iron Homeostasis and What Goes Wrong?
Journal of Renal and Hepatic Disorders, 2021 Iron is an essential mineral that is vital for growth development, normal cellular function, synthesis of hormones and connective tissue, and most importantly, serves as a component of hemoglobin to carry oxygen to body tissues. The body finely regulates
Ernesto Robalino Gonzaga +4 more
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Nitric oxide and glutathione impact the expression of iron uptake- and iron transport-related genes as well as the content of metals in A. thaliana plants grown under iron deficiency [PDF]
, 2012 Mounting evidence indicate that nitric oxide (NO) acts as a signaling molecule mediating iron deficiency responses through the up-regulation of the expression of iron uptake-related genes.
Dobrowolska, Grażyna, Szymańska, K
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Mitochondrial Iron Metabolism: The Crucial Actors in Diseases
Molecules, 2022 Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to ...
Geyan Duan +10 more
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NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms
Haematologica, 2019 Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis.
Naiara Santana-Codina +11 more
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PLoS Pathogens, 2019 Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown.
Zhihui Wang +7 more
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Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae [PDF]
, 2013 Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox cofactor in a wide variety of biological processes.
Romero, Antonia +7 more
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Alterations of iron metabolism during heart ischemia/reperrfusion injury. Cytoprotective effects of Simvastatin. [PDF]
, 2011 Ischemic heart disease, the main cause of mortality and morbidity in industrialized countries, is a metabolic phenomenon due to an inadequate oxygenation of heart tissue caused by the closing or narrowing of the coronary arteries.
Di Pascale, Antonio
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Duodenal Lamina Propria Transferrin—A New Player in the Mucosal Block of Dietary Iron Absorption? [PDF]
Indian Journal of Medical BiochemistryIron is an essential trace element, and its homeostasis is subjected to strict regulatory mechanisms. Hepcidin, a liver synthesized antimicrobial peptide, is the master regulator of systemic iron homeostasis.
Jagadish Ramasamy
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Frontiers in Genetics, 2022 Due to iron’s essential role in cellular metabolism, most organisms must maintain their homeostasis. In this regard, the fission yeast Schizosaccharomyces pombe (sp) uses two transcription factors to regulate intracellular iron levels: spFep1 under iron ...
Alia Ebrahim +8 more
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Iron deficiency in parkinsonism : region-specific iron dysregulation in Parkinson's disease and multiple system atrophy [PDF]
Alpha synuclein pathology is widespread and found in diverse cell types in multiple system atrophy (MSA) as compared to Parkinson's disease (PD). The reason for this differential distribution is unknown.
Visanji, Naomi P. +5 more
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