Results 21 to 30 of about 1,598,338 (286)
Iron homeostasis in the lung [PDF]
Biological Research, 2006 Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated. Constant exposure to the atmosphere results in significant exposure of the lungs to catalytically active iron.
GHIO, ANDREW J +4 more
openaire +4 more sources
Annual Review of Entomology, 2023 Iron is an essential micronutrient for all types of organisms; however, iron has chemical properties that can be harmful to cells. Because iron is both necessary and potentially damaging, insects have homeostatic processes that control the redox state, quantity, and location of iron in the body.
openaire +2 more sources
Microbiology Spectrum, 2023 Zinc excess is toxic to bacteria and, thus, represents an important innate defense mechanism of host cells, especially against mycobacterial infections.
Xiaohui Li +4 more
doaj +1 more source
Iron Homeostasis in Health and Disease [PDF]
International Journal of Molecular Sciences, 2016 Iron is required for the survival of most organisms, including bacteria, plants, and humans. Its homeostasis in mammals must be fine-tuned to avoid iron deficiency with a reduced oxygen transport and diminished activity of Fe-dependent enzymes, and also iron excess that may catalyze the formation of highly reactive hydroxyl radicals, oxidative stress ...
Gozzelino, Raffaella, AROSIO, Paolo
openaire +2 more sources
Abnormal iron homeostasis and neurodegeneration [PDF]
Frontiers in Aging Neuroscience, 2013 Abnormal iron metabolism is observed in many neurodegenerative diseases, however, only two have shown dysregulation of brain iron homeostasis as the primary cause of neurodegeneration. Herein, we review one of these - hereditary ferritinopathy (HF) or neuroferritinopathy, which is an autosomal dominant, adult onset degenerative disease caused by ...
Muhoberac, Barry B., Vidal, Ruben
openaire +3 more sources
Iron deficiency in parkinsonism : region-specific iron dysregulation in Parkinson's disease and multiple system atrophy [PDF]
, 2013 Alpha synuclein pathology is widespread and found in diverse cell types in multiple system atrophy (MSA) as compared to Parkinson's disease (PD). The reason for this differential distribution is unknown.
Visanji, Naomi P. +11 more
core +1 more source
Iron Uptake and Homeostasis in Microorganisms
, 2010 Preface. Iron is considered to be a minor element employed, in a variety of forms, by nearly all living organisms. In some cases, it is utilised in large quantities, for instance for the formation of magnetosomes within magnetotactic bacteria or ...
core +7 more sources
Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis [PDF]
, 2022 The spleen plays a key role in iron homeostasis. It is the largest filter of the blood and performs iron reuptake from old or damaged erythrocytes. Despite this role, spleen iron concentration has not been measured in a large, population-based cohort. In
Sorokin, E. +27 more
core +1 more source
Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories. [PDF]
, 2016 Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C +7 more
core +1 more source
Antioxidants, 2023 Iron is essential for life. Many enzymes require iron for appropriate function. However, dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species (ROS) via the Fenton reaction and causes devastating effects on cells ...
Jaewang Lee, Dong-Hoon Hyun
doaj +1 more source